Capsaicin Modulates Hepatic and Intestinal Inflammation and Oxidative Stress by Regulating the Colon Microbiota

Antioxidants, Год журнала: 2024, Номер 13(8), С. 942 - 942

Опубликована: Авг. 2, 2024

We aimed to investigate the role of capsaicin (CAP) in modulating lipopolysaccharide (LPS)-induced hepatic and intestinal inflammation, oxidative stress, its colonic microflora mice. Thirty healthy male Kunming mice with similar body weights were randomly assigned three groups: control group (CON), LPS group, CAP ten each group. The CON groups received a daily dose normal saline, respectively, while an equivalent CAP. On 28th day experiment, intraperitoneally injected LPS, was equal volume saline. results lead following conclusions. Compared improved loss lobular structure significantly increased duodenal villus length ratio crypt depth. colon interleukin-10 (IL-10) decreased IL-6, IL-1β, tumor necrosis factor (TNF-α) levels. also catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) expression, malondialdehyde (MDA) relative abundances

Язык: Английский

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Degradation of organophosphate flame retardants by white-rot fungi: Degradation pathways and associated toxicity

The Science of The Total Environment, Год журнала: 2025, Номер 959, С. 178260 - 178260

Опубликована: Янв. 1, 2025

The environmental persistence of organophosphate flame retardants (OPFRs) in water is becoming and concern. White Rot Fungi (WRF) have proven its capability to degrade certain OPFRs such as tributyl phosphate (TBP), tris(2-butoxyethyl) (TBEP), tris(2-chloroethyl) (TCEP) tris(2-chloroisopropyl) (TCPP). Despite this capability, there limited knowledge about the specific pathways involved degradation. In study, three different WRF were paired with individual OPFRs, potential transformation products (TPs) identified by UHPLC-HRMS. Some compounds structures further validated NMR. From these data degradation proposed. TBP was degraded successive hydroxylation hydrolysis reactions, a novel dehydrogenation step suggested. Both TCEP TCPP underwent oxidative dechlorination, experiencing subsequent hydrolysis. Uncommon reductive dehalogenation also observed. environmentally relevant methylation. TBEP generated numerous TPs, mainly dealkylations, along hydroxylation. Notably, demethylation proposed for first time. Additional secondary formed through oxidation initial metabolites. Finally, vivo silico toxicity assessments conducted, identifying TPs potentially toxic.

Язык: Английский

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The isolated Ca-Nx sites in biochar boosting Fe catalyzed Fenton-like oxidation of Tris(2-chloroethyl) phosphate: Properties, mechanisms, and applications

Applied Catalysis B Environment and Energy, Год журнала: 2025, Номер 366, С. 125056 - 125056

Опубликована: Янв. 11, 2025

Язык: Английский

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Exposure to malathion impairs learning and memory of zebrafish by disrupting cholinergic signal transmission, undermining synaptic plasticity, and aggravating neuronal apoptosis

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 137391 - 137391

Опубликована: Янв. 1, 2025

Язык: Английский

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Effects of organophosphate esters on thyroid function during pregnancy: Risk of endocrine disruptors during early- and mid-pregnancy

Journal of Environmental Management, Год журнала: 2025, Номер 377, С. 124570 - 124570

Опубликована: Фев. 21, 2025

Язык: Английский

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Blood Biochemical Biomarkers in Fish Toxicology—A Review

Animals, Год журнала: 2025, Номер 15(7), С. 965 - 965

Опубликована: Март 27, 2025

Blood-based biochemical assays are used as predictive and diagnostic methods to evaluate fish welfare in aquaculture research. The variations of blood parameters commonly biomarkers exposure toxic agents. Blood can help identify the magnitude toxicity mechanisms by which particular agents act on organisms. Some typically measured also be evaluated whole body early developmental stages (embryos larvae) that often toxicological studies. This review assessed usefulness various indices biomarkers. Analysis multiple studies showed toxicity-induced changes most depend agent concentration duration. Also, manifest different sensitivity intoxication, diverse directions may occur. Among parameters, some general physiological stress, while others indicate dysfunctions organs. Moreover, hormonal endpoints seem sensitive but nonspecific intoxication fish.

Язык: Английский

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Identification, characterization, and functional verification of a novel fish-egg lectin (FEL) from the golden pompano, Trachinotus ovatus

Fish & Shellfish Immunology, Год журнала: 2025, Номер unknown, С. 110308 - 110308

Опубликована: Апрель 1, 2025

Язык: Английский

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Occurrence, spatial distributions, sources, and potential risks of organophosphate esters in Yarlung Tsangpo River and its main tributaries on the Tibetan Plateau

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 126385 - 126385

Опубликована: Май 1, 2025

Язык: Английский

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Toxic effects of polystyrene microplastics on atrazine in zebrafish: Exogenous toxicity and endogenous mechanism

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 126519 - 126519

Опубликована: Май 1, 2025

Язык: Английский

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Developmental toxicity and mechanistic insights of tralopyril in marine medaka: Epigenetic disruptions and ferroptosis

Environmental Chemistry and Ecotoxicology, Год журнала: 2025, Номер 7, С. 1046 - 1058

Опубликована: Янв. 1, 2025

Язык: Английский

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