Frontiers in Ecology and Evolution,
Год журнала:
2024,
Номер
12
Опубликована: Май 23, 2024
Intraspecific
variation
in
sex
pheromones
is
a
driver
of
reproductive
isolation
and
speciation
insects.
The
False
Codling
Moth
(FCM)
Thaumatotibia
leucotreta
(Lepidoptera:
Tortricidae)
quarantine
pest
endemic
to
sub-Saharan
Africa
(SSA).
currently
available
precision
control
measures
for
FCM
use
female
pheromone
components
lure
males
into
traps.
However,
the
existing
data
on
composition
pheromone,
especially
isomer
ratios
main
component
(
E/Z
)-8-dodecenyl
acetate,
are
inconsistent
populations
SSA.
This
inconsistency
led
speculation
about
possible
between
geographically
separated
potential
need
local
adjustment
pheromone-based
tools.
This,
however,
requires
comparative
evaluation
geographic
sexual
communication
inter-population
mating
compatibility.
We
therefore
investigated
genetic
compatibility
five
isolated
South
analysed
ratio
E
)-
Z
acetate
females
from
these
populations.
studied
were
found
form
three
genetically
distinct
groups
with
high
distances
each
other.
Mating
tests
showed
that
across
groups,
preferred
their
own
population
when
given
choices;
without
choice,
successfully
mated
transferred
spermatophores
all
other
was
similar
(c.
4:1)
populations,
indicating
this
does
not
cause
observed
intra-population
preferences.
It
remains
be
if
qualitative/quantitative
influences
recognition
African
FCM,
providing
base
development
regionally-specific
lures
area-wide
programmes.
Environmental Science & Technology,
Год журнала:
2023,
Номер
57(44), С. 16918 - 16928
Опубликована: Окт. 23, 2023
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
of
high
concern,
with
calls
to
regulate
them
as
a
class.
In
2021,
the
Organisation
for
Economic
Co-operation
Development
(OECD)
revised
definition
PFAS
include
any
chemical
containing
at
least
one
saturated
CF2
or
CF3
moiety.
The
consequence
is
that
largest
open
collections,
PubChem,
116
million
compounds,
now
contains
over
7
under
this
definition.
These
numbers
several
orders
magnitude
higher
than
previously
established
lists
(typically
thousands
entries)
pose
an
incredible
challenge
researchers
computational
workflows
alike.
This
article
describes
dynamic,
openly
accessible
effort
navigate
explore
>7
>21
fluorinated
compounds
(September
2023)
in
PubChem
by
establishing
"PFAS
Fluorinated
Compounds
PubChem"
Classification
Browser
(or
"PubChem
Tree").
A
total
36500
nodes
support
browsing
content
according
categories,
including
classification,
structural
properties,
regulatory
status,
presence
existing
suspect
lists.
Additional
annotation
associated
data
can
be
used
create
subsets
(and
thus
manageable
databases)
interest
wide
range
environmental,
regulatory,
exposomics,
other
applications.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(29), С. 12784 - 12822
Опубликована: Июль 10, 2024
In
the
modern
"omics"
era,
measurement
of
human
exposome
is
a
critical
missing
link
between
genetic
drivers
and
disease
outcomes.
High-resolution
mass
spectrometry
(HRMS),
routinely
used
in
proteomics
metabolomics,
has
emerged
as
leading
technology
to
broadly
profile
chemical
exposure
agents
related
biomolecules
for
accurate
measurement,
high
sensitivity,
rapid
data
acquisition,
increased
resolution
space.
Non-targeted
approaches
are
increasingly
accessible,
supporting
shift
from
conventional
hypothesis-driven,
quantitation-centric
targeted
analyses
toward
data-driven,
hypothesis-generating
exposome-wide
profiling.
However,
HRMS-based
exposomics
encounters
unique
challenges.
New
analytical
computational
infrastructures
needed
expand
analysis
coverage
through
streamlined,
scalable,
harmonized
workflows
pipelines
that
permit
longitudinal
tracking,
retrospective
validation,
multi-omics
integration
meaningful
health-oriented
inferences.
this
article,
we
survey
literature
on
state-of-the-art
technologies,
review
current
informatic
pipelines,
provide
an
up-to-date
reference
exposomic
chemists,
toxicologists,
epidemiologists,
care
providers,
stakeholders
health
sciences
medicine.
We
propose
efforts
benchmark
fit-for-purpose
platforms
expanding
space,
including
gas/liquid
chromatography-HRMS
(GC-HRMS
LC-HRMS),
discuss
opportunities,
challenges,
strategies
advance
burgeoning
field
exposome.
Environmental Science & Technology Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 24, 2025
Finding
relevant
chemicals
in
the
vast
(known)
chemical
space
is
a
major
challenge
for
environmental
and
exposomics
studies
leveraging
nontarget
high
resolution
mass
spectrometry
(NT-HRMS)
methods.
Chemical
databases
now
contain
hundreds
of
millions
chemicals,
yet
many
are
not
relevant.
This
article
details
an
extensive
collaborative,
open
science
effort
to
provide
dynamic
collection
environmental,
metabolomics,
research,
along
with
supporting
information
about
their
relevance
assist
researchers
interpretation
candidate
hits.
The
PubChemLite
Exposomics
compiled
from
ten
annotation
categories
within
PubChem,
enhanced
patent,
literature
counts,
predicted
partition
coefficient
(logP)
values,
as
well
collision
cross
section
(CCS)
values
using
CCSbase.
Monthly
versions
archived
on
Zenodo
under
CC-BY
license,
reproducible
new
interface
has
been
developed,
including
historical
trends
patent
data,
browse
collection.
how
can
support
studies,
describes
efforts
increase
availability
experimental
CCS
explores
known
limitations
potential
future
developments.
data
code
behind
these
openly
available.
be
browsed
at
https://pubchemlite.lcsb.uni.lu.
Environmental Health Perspectives,
Год журнала:
2024,
Номер
132(7)
Опубликована: Июль 1, 2024
Environmental
contamination
by
fluorinated
chemicals,
in
particular
chemicals
from
the
per-
and
polyfluoroalkyl
substances
(PFAS)
class,
has
raised
concerns
around
globe
because
of
documented
adverse
impacts
on
human
health,
wildlife,
ecosystem
quality.
Recent
studies
have
indicated
that
pesticide
products
may
contain
a
variety
meet
PFAS
definition,
including
active
ingredients
themselves.
Given
pesticides
are
some
most
widely
distributed
pollutants
across
world,
legacy
addition
into
could
be
widespread
wide-ranging
implications
agriculture
food
water
contamination,
as
well
presence
rural
environments.
Science,
Год журнала:
2024,
Номер
386(6719), С. 301 - 309
Опубликована: Окт. 17, 2024
Human
biomonitoring
studies
typically
capture
only
a
small
and
unknown
fraction
of
the
entire
chemical
universe.
We
combined
analysis
with
high-throughput
in
vitro
assay
for
neurotoxicity
to
complex
mixtures
organic
chemicals
blood.
Plasma
samples
624
pregnant
women
from
German
LiNA
cohort
were
extracted
nonselective
extraction
method
chemicals.
294
>1000
target
analytes
detected
quantified.
Many
as
well
whole
extracts
interfered
neurite
development.
Experimental
testing
simulated
confirmed
additive
mixture
effects
at
concentrations
less
than
individual
chemicals'
effect
thresholds.
The
use
screening
bioassays
has
potential
improve
human
provide
new
approach
including
epidemiological
studies.
Environment International,
Год журнала:
2024,
Номер
190, С. 108844 - 108844
Опубликована: Июнь 22, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS)
receive
global
attention
due
to
their
adverse
effects
on
human
health
the
environment.
Fish
consumption
is
a
major
source
of
PFAS
exposure.
The
aim
this
work
was
address
lack
harmonization
within
legislations
(in
EU
USA)
highlight
level
in
fish
exposed
pollution
from
diffuse
sources
context
current
safety
thresholds.
A
non-exhaustive
literature
review
carried
out
obtain
concentrations
wild
Norwegian
mainland,
Svalbard,
Netherlands,
USA,
as
well
sea
regions
(North
Sea,
English
Channel,
Atlantic
Ocean),
farmed
Dutch
market.
Median
sum
wet
weight
PFOA,
PFNA,
PFHxS,
PFOS
ranged
between
0.1
µg
kg
JACS Au,
Год журнала:
2024,
Номер
4(7), С. 2412 - 2425
Опубликована: Июнь 20, 2024
Around
two-thirds
of
chronic
human
disease
can
not
be
explained
by
genetics
alone.
The
Lancet
Commission
on
Pollution
and
Health
estimates
that
16%
global
premature
deaths
are
linked
to
pollution.
Additionally,
it
is
now
thought
humankind
has
surpassed
the
safe
planetary
operating
space
for
introducing
human-made
chemicals
into
Earth
System.
Direct
indirect
exposure
a
myriad
chemicals,
known
unknown,
poses
significant
threat
biodiversity
health,
from
vaccine
efficacy
rise
antimicrobial
resistance
as
well
autoimmune
diseases
mental
health
disorders.
exposome
chemical
remains
largely
uncharted
due
sheer
number
possible
structures,
estimated
at
over
10
FEMS Microbiology Ecology,
Год журнала:
2023,
Номер
99(10)
Опубликована: Сен. 4, 2023
Environmental
pollution
is
one
of
the
main
challenges
faced
by
humanity.
By
their
ubiquity
and
vast
range
metabolic
capabilities,
microorganisms
are
affected
with
consequences
on
host
organisms
functioning
environment.
They
also
play
key
roles
in
fate
pollutants
through
degradation,
transformation,
transfer
organic
or
inorganic
compounds.
Thus,
they
crucial
for
development
nature-based
solutions
to
reduce
bio-based
environmental
risk
assessment
chemicals.
At
intersection
between
microbial
ecology,
toxicology,
biogeochemistry,
ecotoxicology
a
fast-expanding
research
area
aiming
decipher
interactions
microorganisms.
This
perspective
paper
gives
an
overview
identified
Ecotoxicomic
network
within
emerging
One
Health
framework
light
ongoing
interest
biological
approaches
remediation
current
state
art
ecology.
We
highlight
prevailing
knowledge
gaps
pitfalls
exploring
complex
among
environment
context
chemical
pinpoint
areas
where
future
efforts
needed.
