An
alternative
metric
to
account
for
particulate
matter
(PM)
composition-based
toxicity
is
the
ability
of
PM-species
generate
reactive
oxygen
species
(ROS)
and
deplete
antioxidants,
so-called
oxidative
potential
(OP).
Acellular
OP
assays
are
most
used
worldwide,
mainly
those
based
on
ascorbic
acid
(AA)
dithiothreitol
(DTT)
depletion;
values
calculated
from
AA/DTT
concentration
over
time
kinetic
curves.
Since
a
great
variability
in
OP-DTT
OP-AA
can
be
found
literature,
understanding
factors
affecting
rate
AA
DTT
oxidation
presence
PM-bound
will
improve
interpretation
values.
In
this
work,
study
driven
by
usually
PM
(transition
metals
naphthoquinone
(NQ))
was
carried
out.
particular,
influence
Cu(II),
Fe(II),
Fe(III),
Mn(II),
Mn(III),
1,4-NQ,
type
fluid
assay
(phosphate
buffer
(PB),
phosphate
saline
(PBS)
artificial
lysosomal
(ALF))
analysed
discussed.
The
reaction
orders
with
respect
active
compound,
constants
were
also
determined.
results
show
among
studied
depending
used;
mostly
higher
PB0.05M,
followed
PBS1x
ALF.
Moreover,
different
concentration-responses
OP-DTT/OP-AA
obtained.
These
differences
explained
obtained
each
compound
fluid.
Environmental Science & Technology Letters,
Год журнала:
2024,
Номер
11(3), С. 223 - 229
Опубликована: Фев. 9, 2024
Trace
element
is
known
to
be
one
major
component
in
determining
particulate
matter
(PM)
toxicities.
However,
there
still
no
accurate
assessment
of
the
toxic
potency
mixed
valences.
Here,
we
reported
oxidative
stress
and
cytotoxicity
potencies
14
trace
elements
their
various
valence
states
estimated
gaps
inorganic
PM
resulting
from
variations
Substantial
discrepancies
up
3
orders
magnitude
were
observed
among
different
When
considering
abundance
PM,
toxicity
are
range
5
6
times
between
greatest
weakest
emitted
industrial
sources,
with
iron
contributing
65.5%–91.0%
overall
gaps.
Furthermore,
relative
variation
shows
a
significant
correlation
additive
toxicities
Fe(II)
Fe(III)
ions
during
aging
process.
The
finding
highlights
that
multiple
coexisting
need
taken
into
account
when
estimating
potencies.
Chemosphere,
Год журнала:
2024,
Номер
361, С. 142435 - 142435
Опубликована: Май 24, 2024
An
alternative
metric
to
account
for
particulate
matter
(PM)
composition-based
toxicity
is
the
ability
of
PM-species
generate
reactive
oxygen
species
(ROS)
and
deplete
antioxidants,
so-called
oxidative
potential
(OP).
Acellular
OP
assays
are
most
used
worldwide,
mainly
those
based
on
ascorbic
acid
(AA)
dithiothreitol
(DTT)
depletion;
values
calculated
from
AA/DTT
concentration
over
time
kinetic
curves.
Since
a
great
variability
in
OP-DTT
OP-AA
can
be
found
literature,
understanding
factors
affecting
rate
AA
DTT
oxidation
presence
PM-bound
will
improve
interpretation
values.
In
this
work,
study
driven
by
usually
PM
(transition
metals
naphthoquinone
(NQ))
was
carried
out.
particular,
influence
Cu(II),
Fe(II),
Fe(III),
Mn(II),
Mn(III),
1,4-NQ,
type
fluid
assay
(phosphate
buffer
(PB),
phosphate
saline
(PBS)
artificial
lysosomal
(ALF))
analysed
discussed.
The
reaction
orders
with
respect
active
compound,
constants
were
also
determined.
results
show
among
studied
depending
used;
mostly
higher
PB0.05
M,
followed
PBS1x
ALF.
Moreover,
different
concentration-responses
OP-DTT/OP-AA
obtained.
These
differences
explained
obtained
each
compound
fluid.
Environmental Science & Technology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Secondary
organic
aerosol
(SOA)
comprises
the
majority
of
submicron
particles
and
is
important
for
air
pollution,
health,
climate.
When
SOA
mixes
with
inorganic
containing
transition
metals
(e.g.,
Fe),
chemical
reactions
altering
physicochemical
properties
can
occur.
Here,
we
study
Fe's
impact
on
formation
composition
formed
via
dark
α-pinene
ozonolysis
either
(NH
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 22, 2025
It
is
urgent
to
exploit
multifunctional
materials
and
combined
approaches
for
efficient
antitumor
effects.
Copper-based
metal–organic
frameworks
(Cu-MOFs)
have
excellent
performances
in
catalysis,
biocompatibility,
photothermal
conversion,
regulate
metabolism,
which
make
them
attract
more
attention
application.
Therefore,
this
review,
representative
ligands,
synthetic
methods,
mechanism,
applications
of
Cu-MOFs
were
provided.
Special
emphasis
placed
on
the
recent
drug
carriers,
therapy,
tumor
imaging,
theranostic,
are
summarized
with
examples.
Finally,
we
presented
dilemma
faced
by
offered
a
new
perspective
future
Hopefully,
review
may
serve
as
reference
further
development
application
Cu-MOFs.
Exposure
to
airborne
particulate
matter
(PM)
has
been
attributed
millions
of
deaths
annually.
However,
the
PM
components
responsible
for
observed
health
effects
remain
unclear.
Oxidative
potential
(OP)
gained
increasing
attention
as
a
key
property
that
may
explain
toxicity.
Using
online
measurement
methods
impinge
particles
OP
quantification
within
seconds,
we
reveal
60
99%
reactive
oxygen
species
(ROS)
and
in
secondary
organic
aerosol
combustion-generated
have
lifetime
minutes
hours
ROS
activity
ambient
decays
substantially
before
offline
analysis.
This
implies
current
underestimate
true
PM.
We
demonstrate
short-lived
activate
different
toxicity
pathways
upon
direct
deposition
onto
reconstituted
human
bronchial
epithelia.
Therefore,
suggest
future
air
pollution
studies
should
include
quantification,
allowing
more
accurate
assessments
links
between
effects.
Aerosol Research,
Год журнала:
2025,
Номер
3(1), С. 205 - 218
Опубликована: Апрель 22, 2025
Abstract.
Air
pollution
is
one
of
the
largest
environmental
health
risks
and
leading
causes
adverse
outcomes
mortality
worldwide.
The
possible
importance
oxidative
potential
(OP)
as
a
metric
to
quantify
particle
toxicity
in
air
increasingly
being
recognised.
In
this
work,
OP
reactive
oxygen
species
(ROS)
activity
particles
from
fresh
aged
petrol
passenger
car
emissions
residential
wood
combustion
(RWC)
were
investigated
using
two
novel
instruments.
Applying
online
instruments
an
ascorbic
acid
(AA)
2′,7′-dichlorodihydrofluorescein
(DCFH)
assay
provides
much
higher
temporal
resolution
compared
with
traditional
filter-based
methods
allows
for
new
insights
into
highly
dynamic
changes
ROS
these
sources.
Due
efficiency
particulate
filter
Euro
6d
car,
almost
no
primary
emitted
and,
thus,
or
was
detected
exhaust.
However,
substantial
ROSs
observed
after
photochemical
ageing
due
formation
secondary
particles.
Increasing
also
when
comparing
RWC
emissions.
Overall,
had
signals
This
suggests
that
could
be
major
contributor
may
intrinsically
more
harmful
emission
source
than
exhaust,
although
still
high.
These
measurements
illustrate
strong
differences
nature
toxicity-relevant
properties
sources
contribute
efficient
mitigation
policies.
Atmosphere,
Год журнала:
2024,
Номер
15(1), С. 127 - 127
Опубликована: Янв. 20, 2024
There
is
a
need
for
monitoring
air
pollution
associated
with
black
carbon
(BC)
using
passive
monitor
required
in
remote
areas
where
the
measurements
are
absent.
In
this
pilot
study,
we
developed
quantitative
method
to
determine
dry
deposition
submicron
BC
dual-wavelength
ultraviolet–visible
spectroscopy.
Furthermore,
measured
levels
of
on
plant
leaves
from
30
species
located
urban
Nanjing
established
method.
The
oxidative
potential
as
bio-monitoring
samplers
was
assessed.
concentrations
tree
varied
0.01
1.6
mg
m−2.
Significant
differences
across
different
types
were
observed.
values
deposited
particles
leaf
samples
observed
be
range
33–46
nmol
min−1
mg−1
dithiothreitol
(DTT)
assay
and
18–32
ascorbic
acid
(AA)
assay,
respectively.
comparison,
BC-dominated
mass
water
extracts
5–35
DTT
2
12
AA
We
found
variations
OP
not
large,
while
terms
greatly.
These
results
indicate
that
spectroscopy
could
provide
simple
tool
monitor.
