Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 24, 2024
Background
and
objective
The
incidence
of
central
precocious
puberty
(CPP)
in
girls
increased
significantly
during
the
COVID-19
pandemic.
This
study
aimed
to
explore
impact
perfluorinated
endocrine
disruptors
on
CPP
through
metabolomics
analysis
from
Hainan
Province,
China.
Methods
Serum
samples
100
with
healthy
controls
were
collected.
Untargeted
profiling
was
performed
using
ultra-high
performance
liquid
chromatography
coupled
quadrupole-Exactive
Orbitrap
mass
spectrometry
(UHPLC-Q-Exactive-Orbitrap-MS).
Differentially
expressed
metabolites
(DEMs)
screened,
pathway
enrichment
conducted.
Results
Principal
component
(PCA)
partial
least
squares
discriminant
(PLS-DA)
revealed
distinct
metabolic
profiles
between
control
groups.
A
total
511
identified,
including
296
up-regulated
DEMs
255
down-regulated
DEMs.
Three
compounds—PFSM-perfluoroalkyl_sulfonamide_Me,
PFSM-FSAA,
PFCA-unsaturated—were
upregulated
group.
KEGG
suggested
involvement
multiple
pathways
process
regulated
by
these
compounds.
Conclusions
Perfluorinated
compounds
may
promote
interfering
various
affecting
hypothalamic-pituitary-gonadal
axis
function.
highlighted
need
for
further
research
public
health
measures
address
environmental
disruptors.
Journal of Exposure Science & Environmental Epidemiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 17, 2024
Over
1800
food
contact
chemicals
(FCCs)
are
known
to
migrate
from
articles
used
store,
process,
package,
and
serve
foodstuffs.
Many
of
these
FCCs
have
hazard
properties
concern,
still
others
never
been
tested
for
toxicity.
Humans
be
exposed
via
foods,
but
the
full
extent
human
exposure
all
is
unknown.
ACS Materials Letters,
Год журнала:
2024,
Номер
6(8), С. 3254 - 3263
Опубликована: Июнь 24, 2024
Leakage
of
oils
in
water
bodies
is
a
common
phenomenon
due
to
enhanced
industrialization.
Herein,
we
have
fabricated
composite
material
IPMOP-PA@Foam
through
the
situ
coating
melamine
foam
with
nonfluorinated
superhydrophobic
chemically
robust
metal–organic
polyhedron
(IPMOP-PA)
at
room
temperature.
IPMOP-PA
owing
its
excellent
solution
processability
coated
homogeneously
on
showing
good
consistency
and
sustainability
performance.
The
was
capable
producing
multiway
separation
oil
from
various
aquatic
challenges.
had
potential
separate
very
thin
layer
oil,
as
well
tiny
droplets
marine
water.
Moreover,
proficient
separating
complicated
aqueous
environments
like
oil–water
emulsions.
In
addition
being
extremely
important
an
industrial
standpoint,
this
work
investigates
novel
approach
basic
design
for
real-time
applications
challenging
settings.
Understanding
the
molecular
interactions
of
per-
and
polyfluoroalkyl
substances
(PFAS)
with
phospholipids
is
crucial
for
elucidating
their
pathological
mechanisms
developing
PFAS
remediation
strategies.
In
this
study,
we
employ
atomistic
dynamics
simulations
to
examine
insertion
into
phospholipid
bilayers,
including
anionic
perfluorooctanesulfonic
acid
(PFOS),
perfluorobutanoic
(PFBA),
perfluorooctanoic
(PFOA),
perfluorododecanoic
(PFDoA),
as
well
neutral
polytetrafluoroethylene
(PTFE).
Our
study
shows
that
lipid
bilayers
driven
by
free
energy
gradient
between
bulk
water
membrane.
Positively
charged
trimethylammonium
groups
attract
negatively
PFAS,
overcoming
surface
hydration
barrier.
Hydrophobic
fluoroalkyl
tails
chains
generate
a
significant
driving
force
reorientation
insertion.
The
increase
in
electrostatic
potential
across
aids
insertion,
but
dehydration
hinders
further
movement.
enhances
membrane
ordering
decreases
fluidity,
potentially
affecting
cellular
functions
modifying
rigidity.
extended
chain
length
facilitates
its
membrane,
resulting
more
pronounced
influence
on
altering
structural
dynamic
properties.
Chemosphere,
Год журнала:
2025,
Номер
377, С. 144301 - 144301
Опубликована: Апрель 9, 2025
Public
concern
over
per-
and
polyfluoroalkyl
substances
(PFAS)
continues
to
grow
as
evidence
highlights
their
persistence,
bioaccumulation
potential,
adverse
health
effects.
Increasing
detections
in
drinking
water,
consumer
products,
industrial
discharges
have
intensified
regulatory
scrutiny.
This
review
examines
the
evolving
PFAS
landscape
United
States,
focusing
on
pulp,
paper,
textiles
industries,
which
contribute
significantly
contamination
through
wastewater
discharges,
end-product
disposal,
absence
of
dedicated
removal
technologies.
emissions
from
food
packaging
alone
are
estimated
at
2,300
kg
annually.
Addressing
presents
substantial
economic
challenges,
with
treatment
costs
projected
reach
USD
3
billion
annually
growing
risks
legal
liabilities
exemplified
by
paper
mill
settlements
reaching
11.9
million
for
historical
pollution.
Large-scale
remediation
remains
financially
prohibitive,
estimates
exceeding
global
gross
domestic
product
(GDP)
106
trillion.
Additionally,
healthcare
PFAS-linked
diseases
exceed
62
further
emphasize
need
prevention.
State-level
restrictions
PFAS-containing
products
expanding,
particularly
textiles,
now
most
regulated
across
States.
As
face
increasing
market
limitations
potential
loss
sustainability
certifications,
already
reduced
sales
growth
70%
some
cases,
transitioning
non-fluorinated
alternatives
could
mitigate
companies.
Within
this
context,
urgency
integrating
policy,
technological
innovation,
incentives
accelerate
transition
away
long-term
environmental
financial
liabilities.
