Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 24, 2024
Background
and
objective
The
incidence
of
central
precocious
puberty
(CPP)
in
girls
increased
significantly
during
the
COVID-19
pandemic.
This
study
aimed
to
explore
impact
perfluorinated
endocrine
disruptors
on
CPP
through
metabolomics
analysis
from
Hainan
Province,
China.
Methods
Serum
samples
100
with
healthy
controls
were
collected.
Untargeted
profiling
was
performed
using
ultra-high
performance
liquid
chromatography
coupled
quadrupole-Exactive
Orbitrap
mass
spectrometry
(UHPLC-Q-Exactive-Orbitrap-MS).
Differentially
expressed
metabolites
(DEMs)
screened,
pathway
enrichment
conducted.
Results
Principal
component
(PCA)
partial
least
squares
discriminant
(PLS-DA)
revealed
distinct
metabolic
profiles
between
control
groups.
A
total
511
identified,
including
296
up-regulated
DEMs
255
down-regulated
DEMs.
Three
compounds—PFSM-perfluoroalkyl_sulfonamide_Me,
PFSM-FSAA,
PFCA-unsaturated—were
upregulated
group.
KEGG
suggested
involvement
multiple
pathways
process
regulated
by
these
compounds.
Conclusions
Perfluorinated
compounds
may
promote
interfering
various
affecting
hypothalamic-pituitary-gonadal
axis
function.
highlighted
need
for
further
research
public
health
measures
address
environmental
disruptors.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 14, 2025
People
are
exposed
to
per-
and
polyfluoroalkyl
substances
(PFAS)
through
multiple
sources,
with
diet
historically
considered
a
major
source
in
general
populations.
This
study
characterized
legacy
PFAS
serum
from
700
California
adults
examined
contributions
drinking
water.
We
applied
robust
regression
estimate
associations
between
nontransformed
concentrations,
self-reported
food
consumption,
water
concentrations
measured
under
the
USEPA's
third
Unregulated
Contaminant
Monitoring
Rule
(2013-2015).
Detectable
were
associated
increased
perfluorooctanoic
acid
(PFOA)
(0.26
ng/mL;
95%
CI:
0.077,
0.43),
perfluorohexanesulfonic
(PFHxS)
(0.64
0.058,
1.23),
perfluorooctanesulfonic
(PFOS)
(0.39
-0.76,
0.86).
Seafood
consumption
was
perfluorononanoic
(PFNA)
(0.013
0.0058,
0.021),
perfluorodecanoic
(PFDeA)
(0.0059
0.0026,
0.0092),
perfluoroundecanoic
(PFUnDA)
(0.010
0.0054,
0.015),
while
eggs
PFDeA
(0.0035
0.00010,
0.0069)
PFNA
(0.0073
0.00017,
0.014).
Findings
could
indicate
that
dietary
may
be
less
than
those
earlier
studies
conducted
other
populations,
possibly
due
shifts
production
over
past
20
years,
remains
an
important
of
exposure
PFOA
PFHxS
this
population.
Geosynthetics International,
Год журнала:
2025,
Номер
unknown, С. 1 - 9
Опубликована: Май 28, 2025
This
paper
investigates
how
five
PFAS
congeners,
namely,
perfluorooctanoic
acid
(PFOA),
perfluorooctanesulfonic
(PFOS),
perfluorohexanoic
(PFHxA),
perfluorobutane
sulfonate
(PFBS)
and
trifluoromethanesulfonic
(TFMS),
interact
with
a
high
density
polyethylene
(HDPE)
geomembrane,
through
equilibrium
batch
sorption
tests,
to
assess
its
ability
minimise
the
migration
of
these
contaminants.
The
experiments
show
that
HDPE
geomembrane
exhibits
varying
degrees
uptake
for
different
pollutants,
in
following
order:
PFBS
=
TFMS
<
PFHxA
PFOA
PFOS.
Additionally,
minimal
partitioning
congeners
was
observed,
longer-chain
exhibiting
higher
coefficients.
indicates
an
intact
can
potentially
slow
down
pollutants.
PFOS
exhibited
slightly
stronger
affinity
than
PFOA,
likely
due
hydrophobicity
and/or
electronegativity.
Langmuir,
Год журнала:
2024,
Номер
40(47), С. 24820 - 24831
Опубликована: Ноя. 14, 2024
Surface
tension,
conductivity,
and
dynamic
light
scattering
(DLS)
measurements
were
used
to
examine
the
surface
bulk
solution
behaviors
of
three
members
PFAS
family,
perfluorooctanoic
acid
(PFOA),
perfluorobutanesulfonic
(PFBS),
potassium
salt
perfluorooctanesulfonic
(PFOS).
Measurements
carried
out
in
solutions
having
variable
(acidic)
pH
buffered
=
8.0.
tension
data
show
traditional
soluble
surfactant
behavior,
results
illustrate
that
PFOA,
PFBS,
PFOS
activity
depends
sensitively
on
phase
pH.
The
tightly
packed
monolayers
formed
by
PFOA
mildly
acidic
imply
is
several
units
lower
than
bulk.
Results
from
conductivity
experiments
generally
increasing
with
concentration.
In
8.0
solutions,
changes
slope
concentration
suggest
onset
micelle
formation
at
concentrations
<1
mM,
markedly
reported
literature.
general,
apparent
critical
(CMCs)
determined
agree
similar
predictions
made
results.
DLS
close
predicted
CMCs,
objects
diameters
≤10
nm
start
form.
However,
unlike
micelles,
these
continue
grow
solute
These
aggregates
form
structures
50-150
nm.
Aggregate
size
shrinks
modestly
as
temperature
increases,
this
behavior
reversible.
Cryo-EM
images
confirm
a
broad
distribution
particles,
supporting
measurements.
Findings
work
represent
first
evidence
EPA-regulated
surfactants
rather
micelles
solution.
also
begin
reconcile
differences
have
led
CMC
literature
varying
more
an
order
magnitude.
