The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 272, С. 116023 - 116023

Опубликована: Янв. 30, 2024

An in vivo model is necessary for toxicology. This review analyzed the uses of zebrafish (Danio rerio) toxicology based on bibliometrics. Totally 56,816 publications about from 2002 to 2023 were found Web Science Core Collection, with Toxicology as top 6 among all disciplines. Accordingly, bibliometric map reveals that "toxicity" has become a hot keyword. It further most common exposure types include acute, chronic, and combined exposure. The toxicological effects behavioral, intestinal, cardiovascular, hepatic, endocrine toxicity, neurotoxicity, immunotoxicity, genotoxicity, reproductive transgenerational toxicity. mechanisms oxidative stress, inflammation, autophagy, dysbiosis gut microbiota. toxicants commonly evaluated by using nanomaterials, arsenic, metals, bisphenol, dioxin. Overall, provide unique well-accepted investigate mechanisms. We also discussed possible ways address some limitations model, such combination human organoids avoid species differences.

Язык: Английский

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Paternal exposures to endocrine-disrupting chemicals induce intergenerational epigenetic influences on offspring: A review

Environment International, Год журнала: 2024, Номер 187, С. 108689 - 108689

Опубликована: Апрель 24, 2024

Endocrine-disrupting chemicals (EDCs) are ubiquitous in ecological environments and have become a great issue of public health concern since the 1990 s. There is deep scientific understanding toxicity EDCs. However, recent studies found that abnormal physiological functions parents caused by EDCs could be transmitted to their unexposed offspring, leading intergenerational toxicity. We questioned whether sustained epigenetic changes occur through male germline. In this review, we (1) systematically searched available research on impacts aquatic mammal organisms, including 42 articles, (2) summarized genetic effects, such as decreased offspring survival, reproductive dysfunction, metabolic disorders, behavioral abnormalities, (3) mechanisms paternal interactions, (4) propose suggestions future directions develop deeper risk

Язык: Английский

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Thiamethoxam at environmentally relevant concentrations induces neurotoxicity in zebrafish larvae through binding with multiple receptors

Eco-Environment & Health, Год журнала: 2025, Номер 4(1), С. 100133 - 100133

Опубликована: Янв. 18, 2025

Thiamethoxam (THM) is one of the most widely used insecticides globally, which was designed to selectively target nicotinic acetylcholine receptors (nAChRs) in insect nervous system and generally considered safe for non-targeted organisms. However, increasing evidence has demonstrated its neurotoxicity aquatic organisms, though underlying mechanisms, especially at environmentally relevant concentrations, remain largely unclear. In this study, swimming distance zebrafish significantly shortened by 14.06%-21.64% after exposure THM 10-1000 ng/L. This behavioral impairment may result from damage visual systems, as confirmed notable apoptosis, histological analysis eyes, differential expression numerous genes. Molecular docking biomarkers assays found that can bind with nAChR multiple hormone receptors, binding energies varying -3.75 -6.74 kcal/mol. Consequently, concentrations a neurotransmitter (acetylcholine) related hormones (cortisol, triiodothyronine, thyroxine, thyroid-stimulating hormone) were affected. Further investigations using weighted gene correlation network metabolomics suggest enter cell via endocytosis potentially activating MAPK signaling pathway. activation disrupt purine pyrimidine metabolism nucleus, ultimately leading apoptosis neurotoxicity. study reveals THM, even poses neurological risks underscore need urgent attention ecological impacts environments.

Язык: Английский

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New Isoxazoline Cyclopropyl-Picolinamide Derivatives as Potential Insecticides

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Isoxazoline insecticides exhibit broad-spectrum insecticidal activity against insect pests. However, the high toxicity to honeybees limits their application in pest management. To explore reducing of isoxazoline derivatives bees, a series new cyclopropyl-picolinamide were designed and synthesized. Bioassays revealed that FSA37 showed excellent Plutella xylostella, Spodoptera litura, exigua, with LC50 values 0.077, 0.104, 0.198 mg/L, respectively. These results surpass those fluxametamide, which displayed 0.605, 0.853, 1.254 mg/L. Furthermore, exhibited notable Solenopsis invicta. Importantly, bee studies indicated possesses significantly lower acute oral compared fluralaner fluxametamide. Quantum chemical calculations molecular docking suggest fragment may be crucial for both biological safety nontarget organisms. In conclusion, represents promising candidate highly effective environmentally friendly insecticide.

Язык: Английский

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Enhancement of the radical pathway-dominated degradation of imidacloprid in PMS-AOP by 1 T-MoS2-based dual-atom catalyst: Synergistic catalysis by Fe and Ni atoms

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162063 - 162063

Опубликована: Апрель 1, 2025

Язык: Английский

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An azole fungicide climbazole damages the gut-brain axis in the grass carp

Journal of Hazardous Materials, Год журнала: 2024, Номер 465, С. 133463 - 133463

Опубликована: Янв. 10, 2024

Язык: Английский

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Parental exposure to Cypermethrin causes intergenerational toxicity in zebrafish offspring

The Science of The Total Environment, Год журнала: 2024, Номер 935, С. 173456 - 173456

Опубликована: Май 22, 2024

Язык: Английский

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Neonicotinoid Insecticides in the Qiantang River: Occurrence, Sources, and Ecological Risks for Sustainable Water Resources

Sustainability, Год журнала: 2025, Номер 17(2), С. 697 - 697

Опубликована: Янв. 17, 2025

Neonicotinoid insecticides (NNIs) can harm non-target species. This study examines NNIs’ distribution, sources, human exposure risks, and ecological risks in the Qiantang River’s water sediment. NNIs concentrations ranged from 8.92 to 88.0 ng/L 0.55 16.6 ng/g dw The showed a trend of middle reaches > lower upper reaches. Agricultural activities were main source, followed by wastewater treatment plants. Infants had highest intake, with daily intake 15.4 ng/kg body weight, about 5.4-times higher than adolescents. Using species sensitivity distribution relative potency factor, acute chronic toxicity thresholds for aquatic organisms estimated at HC5 values 3636 40 ng/L, respectively. Species trophic levels more sensitive NNIs. While fauna are low, prolonged poses potential health. These findings contribute enhancement regulatory framework serve as reference policymakers formulating pollution management strategies, thereby advancing sustainable development resources region.

Язык: Английский

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Neonicotinoid insecticide causes multigenerational impairment of inducible antipredator defenses in Daphnia

Environmental Research, Год журнала: 2025, Номер 271, С. 121076 - 121076

Опубликована: Фев. 7, 2025

Язык: Английский

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Thiamethoxam Exposure Impairs Oocyte Maturation via Induction of Lipid Metabolism and Mitochondrial Dysfunctions in Porcine

Reproduction in Domestic Animals, Год журнала: 2025, Номер 60(3)

Опубликована: Март 1, 2025

ABSTRACT Neonicotinoid insecticides (NEOs) are the most widely used pesticides in modern agriculture, and there residues environment food. Thiamethoxam (TMX) has been proven to destroy ovarian homeostasis of mice vivo reduce development porcine oocytes vitro. However, whether TMX can interfere with oocyte maturation its potential mechanism remains unknown. This study indicated that affects expansion cumulus cells, destroys balance lipid metabolism, damages mitochondrial function. treatment decreased expression genes related cell expansion, synthesis synthesis. Collectively, results confirm exposure damage produce reproductive toxicity by inducing metabolism dysfunction porcine.

Язык: Английский

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