Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans

Journal of Hazardous Materials, Год журнала: 2024, Номер 471, С. 134356 - 134356

Опубликована: Апрель 19, 2024

Язык: Английский

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A Systematic Review of Biomonitoring Microplastics in Environmental Matrices: Emphasis on Airborne Particles, Dry Deposits, and Comparative Analysis with Traditional Methods

Environmental Advances, Год журнала: 2025, Номер unknown, С. 100609 - 100609

Опубликована: Янв. 1, 2025

Язык: Английский

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Bisphenol S accelerates the progression of high fat diet-induced NAFLD by triggering ferroptosis via regulating HMGCS2

Journal of Hazardous Materials, Год журнала: 2025, Номер 487, С. 137166 - 137166

Опубликована: Янв. 9, 2025

Язык: Английский

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Ferroptosis implication in environmental-induced neurotoxicity

The Science of The Total Environment, Год журнала: 2024, Номер 934, С. 172618 - 172618

Опубликована: Апрель 24, 2024

Язык: Английский

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Targeting ferroptosis in neuroimmune and neurodegenerative disorders for the development of novel therapeutics

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116777 - 116777

Опубликована: Май 24, 2024

Neuroimmune and neurodegenerative ailments impose a substantial societal burden. disorders involve the intricate regulatory interactions between immune system central nervous system. Prominent examples of neuroimmune encompass multiple sclerosis neuromyelitis optica. Neurodegenerative diseases result from neuronal degeneration or demyelination in brain spinal cord, such as Alzheimer's disease, Parkinson's Huntington's amyotrophic lateral sclerosis. The precise underlying pathogenesis these conditions remains incompletely understood. Ferroptosis, programmed form cell death characterised by lipid peroxidation iron overload, plays pivotal role diseases. In this review, we provide detailed overview ferroptosis, its mechanisms, pathways, regulation during progression Furthermore, summarise impact ferroptosis on neuroimmune-related cells (T cells, B neutrophils, macrophages) neural (glial neurons). Finally, explore potential therapeutic implications inhibitors diverse

Язык: Английский

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Polybrominated biphenyls induce liver injury by disrupting the KEAP1/Nrf2/SLC7A11 axis leading to impaired GSH synthesis and ferroptosis in hepatocytes

Archives of Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Язык: Английский

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Regulation of calcium signaling prevents neuronal death mediated by NIST DEP in xenoferroptotic cell death conditions

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 137374 - 137374

Опубликована: Янв. 1, 2025

Язык: Английский

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Design of a Fractional-Order Environmental Toxin-Plankton System in Aquatic Ecosystems: A Novel Machine Predictive Expedition with Nonlinear Autoregressive Neuroarchitectures

Water Research, Год журнала: 2025, Номер unknown, С. 123640 - 123640

Опубликована: Апрель 1, 2025

Язык: Английский

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Ferroptosis induced by environmental pollutants and its health implications

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 24, 2025

Abstract Environmental pollution represents a significant public health concern, with the potential risks associated environmental pollutants receiving considerable attention over an extended period. In recent years, substantial body of research has been dedicated to this topic. Since discovery ferroptosis, iron-dependent programmed cell death typically characterized by lipid peroxidation, in 2012, there have advances study its role and mechanism various diseases. A growing number studies also demonstrated involvement ferroptosis damage caused organism pollutants, molecular mechanisms involved partially elucidated. The targeting be effective means ameliorating PM2.5, organic inorganic ionizing radiation. This review begins providing summary most important ferroptosis. It then proceeds offer critical analysis effects induced pollutants. Furthermore, as is case all rapidly evolving areas, are numerous unanswered questions challenges pertaining pollutant-induced which we discuss attempt provide some directions clues for future field.

Язык: Английский

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Nanobiotechnology boosts ferroptosis: opportunities and challenges

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Окт. 8, 2024

Ferroptosis, distinct from apoptosis, necrosis, and autophagy, is a unique type of cell death driven by iron-dependent phospholipid peroxidation. Since ferroptosis was defined in 2012, it has received widespread attention researchers worldwide. From biochemical perspective, the regulation strongly associated with cellular metabolism, primarily including iron lipid redox metabolism. The distinctive regulatory mechanism holds great potential for overcoming drug resistance-a major challenge treating cancer. considerable role nanobiotechnology disease treatment been widely reported, but further more systematic discussion on how enhances therapeutic efficacy ferroptosis-associated diseases still needs to be improved. Moreover, while exciting cancer relatively well summarized, its applications other diseases, such as neurodegenerative cardiovascular cerebrovascular kidney disease, remain underreported. Consequently, necessary fill these gaps complete ferroptosis. In this review, we provide an extensive introduction background elaborate network. Subsequently, discuss various advantages combining enhance reduce side effects diseases. Finally, analyze feasibility improving clinical outcomes based needs, current limitations future directions ferroptosis, which will not only significant guidance also accelerate their translations.

Язык: Английский

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