New insights into heavy metal cadmium-induced liver injury: prominent role of programmed cell death mechanisms DOI
Ruipeng Wang, Jun Yan, Honglong Zhang

и другие.

Toxicology, Год журнала: 2025, Номер unknown, С. 154169 - 154169

Опубликована: Май 1, 2025

Язык: Английский

Mechanistic Insights into Cadmium Sulfide Nanoparticles-Induced Digestive Gland Damage in Corbicula fluminea: Comparison with Cadmium Ions DOI
Kena Zhang,

Quanzhi Xiao,

Jianbo Jia

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

The extensive use of cadmium sulfide nanoparticles (CdS-NPs), along with their natural formation through the complex biogeochemical transformation anthropogenic ions (Cd2+), poses substantial risks to ecosystems and human health. Despite this, mechanisms underlying toxicity CdS-NPs remain unclear. A key question is whether arises from nanoparticulate form (Cd) or release Cd2+. To explore we exposed freshwater clams (Corbicula fluminea) environmentally relevant concentrations (0.01–1 mg/L) Cd2+ for 10 days. Hematoxylin eosin (HE) staining revealed significant damage digestive gland in both cases. Although released some (≤10.4%), transcriptomic quantitative reverse transcription polymerase chain reaction (qRT-PCR) analyses indicated different mechanisms. primarily induce ferroptosis, triggered by lysosomal dysfunction that releases Fe2+ into cytoplasm, disrupting cellular iron metabolism. In contrast, induces an autophagic response, as evidenced upregulation autophagy-related markers activation apoptosis pathways linked mitochondrial membrane permeabilization. Overall, our findings suggest not solely derived Cd2+, highlighting need evaluate posed metal benthic ecosystems.

Язык: Английский

Процитировано

0
Distinct Neurotoxic Mechanisms of Thallium and Lead: Calcium-Mediated Apoptosis and Iron-Induced Ferroptosis in Zebrafish at Environmental Concentrations DOI
Jian Liu,

Ai Guan,

Zihui Huo

и другие.

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138288 - 138288

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Oxidative stress-mediated tetrabromobisphenol A disrupts mitochondrial function in HepG2 cells and activates ferroptosis signalling to induce apoptosis DOI
Xiaotian Huang,

Zuhong Lin,

Denglong Lu

и другие.

Journal of Environmental Management, Год журнала: 2025, Номер 382, С. 125360 - 125360

Опубликована: Апрель 14, 2025

Язык: Английский

Процитировано

0
Unconventional application of a fluorescent probe for MS-based detection of multiple sulfur species in ferroptosis DOI

Mengyu Cao,

Yiyan Yin,

Jingyi Qin

и другие.

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111260 - 111260

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
New insights into heavy metal cadmium-induced liver injury: prominent role of programmed cell death mechanisms DOI
Ruipeng Wang, Jun Yan, Honglong Zhang

и другие.

Toxicology, Год журнала: 2025, Номер unknown, С. 154169 - 154169

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0