Nutritional Support of Chronic Obstructive Pulmonary Disease

Nutrients, Год журнала: 2025, Номер 17(7), С. 1149 - 1149

Опубликована: Март 26, 2025

Background: COPD is a heterogenous disease of the respiratory tract caused by diverse genetic factors along with environmental and lifestyle-related effects such as industrial dust inhalation and, most frequently, cigarette smoking. These lead to airflow obstruction chronic symptoms. Additionally, increased risk infections exacerbates airway inflammation in patients. As consequence complex pathomechanisms difficulty treatment, among leading causes mortality both western countries developing world. Results: The management still challenge for clinicians; however, alternative interventions smoking cessation lifestyle changes from sedentary life moderate physical activity special attention diet may ameliorate patients' health. Here, we reviewed different dietary components supplements on conditions COPD. Conclusions: patients are continuously exposed heavy metals, which commonly present smoke polluted air. Meanwhile, they often experience significant nutrient deficiencies, affect detoxification these toxic metals. This turn can further disrupt nutritional balance interfering absorption, metabolism, utilization essential micronutrients. Therefore, awareness deliberate efforts should be made check levels micronutrients, ensuring adequate antioxidants, vitamin D, K2, magnesium, iron, particularly important reducing development limiting severity.

Язык: Английский

---

Mechanistic Insights into Cadmium Sulfide Nanoparticles-Induced Digestive Gland Damage in Corbicula fluminea: Comparison with Cadmium Ions

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

The extensive use of cadmium sulfide nanoparticles (CdS-NPs), along with their natural formation through the complex biogeochemical transformation anthropogenic ions (Cd2+), poses substantial risks to ecosystems and human health. Despite this, mechanisms underlying toxicity CdS-NPs remain unclear. A key question is whether arises from nanoparticulate form (Cd) or release Cd2+. To explore we exposed freshwater clams (Corbicula fluminea) environmentally relevant concentrations (0.01–1 mg/L) Cd2+ for 10 days. Hematoxylin eosin (HE) staining revealed significant damage digestive gland in both cases. Although released some (≤10.4%), transcriptomic quantitative reverse transcription polymerase chain reaction (qRT-PCR) analyses indicated different mechanisms. primarily induce ferroptosis, triggered by lysosomal dysfunction that releases Fe2+ into cytoplasm, disrupting cellular iron metabolism. In contrast, induces an autophagic response, as evidenced upregulation autophagy-related markers activation apoptosis pathways linked mitochondrial membrane permeabilization. Overall, our findings suggest not solely derived Cd2+, highlighting need evaluate posed metal benthic ecosystems.

Язык: Английский

---

Distinct Neurotoxic Mechanisms of Thallium and Lead: Calcium-Mediated Apoptosis and Iron-Induced Ferroptosis in Zebrafish at Environmental Concentrations

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138288 - 138288

Опубликована: Апрель 1, 2025

Язык: Английский

---

Oxidative stress-mediated tetrabromobisphenol A disrupts mitochondrial function in HepG2 cells and activates ferroptosis signalling to induce apoptosis

Journal of Environmental Management, Год журнала: 2025, Номер 382, С. 125360 - 125360

Опубликована: Апрель 14, 2025

Язык: Английский

---

Unconventional application of a fluorescent probe for MS-based detection of multiple sulfur species in ferroptosis

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111260 - 111260

Опубликована: Апрель 1, 2025

Язык: Английский

---