Short-term exposure to ciprofloxacin and microplastic leads to intrahepatic cholestasis, while long-term exposure decreases energy metabolism and increases the risk of obesity

Environment International, Год журнала: 2025, Номер 199, С. 109511 - 109511

Опубликована: Май 1, 2025

Microplastics (MPs) and antibiotics are pervasive pollutants that may pose a risk to human health. Studies have shown both MPs adversely affect lipid metabolism increase the of obesity. However, it remains unclear whether combined exposure these intensify cumulative detrimental effect on obesity metabolism. This study demonstrated impact polystyrene (PS, 25 nm) ciprofloxacin (CIP), individually combined, for 30 d 90 hepatic male C57BL/6J mice. The results showed mice exposed PS CIP either or exhibited disorders such as increased body weight, enlarged adipocytes, triglyceride accumulation in liver, higher HDL-C. Differentially expressed proteins were identified via proteomic analysis. findings indicated caused abnormal bile acid (BA) secretion liver inhibited BA pathway, which resulted intrahepatic cholestasis. Furthermore, resolved cholestasis reduced overall number differentially proteins. Intestinal pathology revealed more severe damage after d, while decreased adverse effect. Combined organism. adaptive capacity organism during prolonged mitigated by both, but did not imply complete eradication effects. found weight gain, possibly due changes gut flora suppressed energy These simultaneous exacerbated causing short-term Prolonged body, exhibiting varied toxicity outcomes mechanisms at different durations. offers novel insights into antibiotic metabolic abnormalities provides scientific basis assessing risks. It also emphasizes resulting from (short-term) toxic persist long-term chronic needs warrants.

Язык: Английский

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A Critical Review of Populations with Occupational Exposure to Per- and Polyfluoroalkyl Substances: External Exposome, Internal Exposure Levels, and Health Effects

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

The relationship between per- and polyfluoroalkyl substances (PFAS) exposure human health has received widespread attention. This review focuses on the key distinctions in PFAS occupational population general from different countries. A systematic summary is made external environment, pathways, internal levels, effects of population. manufacturing, use, disposal processes increase their concentration levels ambient leading to significantly higher concentrations than background areas. Different pathways may lead molecular initiating events outcomes Moreover, are nearly one hundred times those Mixed more unknown another important feature Although not associated with mortality, can disrupt metabolic cause adverse liver, kidney, lipid homeostasis. Therefore, stringent protections for necessary reduce risks.

Язык: Английский

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Mitigation of polystyrene microplastic-induced hepatotoxicity in human hepatobiliary organoids through bile extraction

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 288, С. 117330 - 117330

Опубликована: Ноя. 20, 2024

Язык: Английский

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Revealing transport, uptake and damage of polystyrene microplastics using a gut-liver-on-a-chip

Lab on a Chip, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This study employs a gut-liver-on-a-chip (GLOC) to explore microplastics (MPs) transport, absorption, and associated liver damage. Enhanced intestinal peristalsis significantly reduces MPs underscoring its protective role for the liver.

Язык: Английский

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MRI-based microplastic tracking in vivo and targeted toxicity analysis

The Science of The Total Environment, Год журнала: 2024, Номер 954, С. 176743 - 176743

Опубликована: Окт. 6, 2024

Язык: Английский

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