Molecular Mechanisms of Phthalate-Induced Hepatic Injury and Amelioration by Plant-Based Principles
Toxics,
Год журнала:
2025,
Номер
13(1), С. 32 - 32
Опубликована: Янв. 2, 2025
Phthalates
are
the
emerging
environmental
toxicants
derived
from
phthalic
acid
and
its
constituents,
which
moderately
present
in
plastics
many
personal
care
products.
Phthalate
exposure
occurs
through
various
factors,
including
air,
water,
soil,
with
absorption
facilitated
via
ingestion,
inhalation,
dermal
contact.
Upon
exposure,
phthalates
become
bioavailable
within
biological
systems
undergo
biotransformation
detoxification
processes
liver.
The
physicochemical
properties
of
indicate
their
lipophilicity,
persistence,
bioaccumulation
potential,
influencing
absorption,
distribution,
hepatic
biotransformation.
prolonged
to
adversely
influences
redox
system
by
altering
levels
enzymatic
non-enzymatic
antioxidants,
molecular
signaling
pathways,
causing
pathogenesis.
strategies
combat
phthalate-induced
toxicity
include
avoiding
these
compounds
using
plant-based
bioactive
molecules
such
as
polyphenols,
possess
therapeutic
potential
suppress
inflammatory
cascades,
prevent
oxidative
damage,
stabilize
cellular
integrity.
This
review
presents
a
comprehensive
updated
account
chemical,
biochemical,
immunological,
toxicological
phthalates,
along
novel
mitigate
adverse
effects
on
living
systems.
Язык: Английский
Serum Phthalate Biomarkers, Adipose Tissue Metabolites and 20-Years Incidence of Elevated LDL Levels: A Metabolome-Wide Association Study in the <span>GraMo </span>Cohort
Опубликована: Янв. 1, 2025
Язык: Английский
Sustainable Approaches for Managing Phthalate Pollution: Navigating Challenges, and Establishing the Future of Environmental Protection
Eswar Marcharla,
Smarika Chauhan,
Sneha Hariharan
и другие.
Advanced Sustainable Systems,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Abstract
Phthalates
have
become
a
widespread
environmental
pollutant
that
has
severe
implications
for
aquatic
and
terrestrial
ecosystems.
They
are
found
in
various
sources,
including
industrial
processes,
consumer
products,
food
packaging,
resulting
significant
contamination.
Their
persistence
ability
to
bioaccumulate
present
risks,
especially
impacting
reproductive,
developmental,
endocrine
systems
humans.
This
review
explores
how
phthalates
function
as
mixed
micropollutants,
adding
complexity
their
evaluation
control
systems.
It
also
focuses
on
remediation
strategies
using
novel
biotechnological
approaches,
such
enzymatic
degradation,
genetic
engineering,
microbial
remediation,
nanotechnology‐based
approaches.
Enzymatic
degradation
utilizes
specific
enzymes
the
breakdown
of
phthalates,
thereby,
transforming
them
into
less
toxic
metabolites.
Novel
engineering
techniques
opened
possibilities
improving
by
microorganisms,
offering
potential
solutions
more
efficient
remediation.
Nanotechnology‐based
approaches
showcase
effectiveness
nanomaterials
absorbing
breaking
down
molecular
scale.
highlights
importance
consortia
biochar‐microbial
composites
restoration.
The
unique
contribution
this
lies
its
comprehensive
analysis
advanced
phthalate
emphasizing
synergistic
protect
safeguard
environment
future
generations.
Язык: Английский
Establishment of an online pretreatment method for quantifying a novel synthetic cannabinoid receptor agonist, ADMB-FUBIATA, based on turbulent flow chromatography and UHPLC-MS/MS: Application to enzyme kinetics of ADMB-FUBIATA in human liver microsomes at different ethanol concentrations
Xiaolong Hou,
Chenyu Xue,
Zhenjun Jia
и другие.
Microchemical Journal,
Год журнала:
2024,
Номер
unknown, С. 112621 - 112621
Опубликована: Дек. 1, 2024
Язык: Английский