Associations of pre- and postnatal per- and polyfluoroalkyl substance exposure with adolescents’ eating behaviors DOI Creative Commons

Taylor-Marie Vasil,

Elvira S. Fleury, Erica D. Walker

и другие.

Environmental Epidemiology, Год журнала: 2024, Номер 8(5), С. e343 - e343

Опубликована: Сен. 26, 2024

Background: Per- and polyfluoroalkyl substances (PFAS), persistent environmental chemicals, may act as obesogens by interacting with neuroendocrine pathways regulating energy homeostasis satiety signals influencing adolescent eating behaviors. Methods: In 211 HOME Study adolescents (Cincinnati, OH; recruited 2003–2006), we measured PFAS concentrations in serum collected during pregnancy, at delivery, ages 3, 8, 12 years. Caregivers completed the Child Eating Behavior Questionnaire (CEBQ) age 12, calculated food approach avoidance scores. Using quantile-based g-computation, estimated covariate-adjusted associations between a mixture of four gestational CEBQ We identified high (n = 76, 36%) low 135, 64%) longitudinal exposure profiles delivery years using latent profile analysis related these to examined whether child sex or physical activity modified associations. Results: observed no association Children higher had slightly scores ( β : 0.47, 95% CI: −0.27, 1.23) similar −0.15, −0.75, 0.46) compared children lower profile. found some evidence that favorably emotional overeating (interaction P value 0.13). did not consistently modify any Conclusions: Serum were linked behaviors this study, suggesting alternative pathways, such metabolic rate, underlie previously childhood obesity.

Язык: Английский

Broad-spectrum capture of hundreds of per- and polyfluoroalkyl substances from fluorochemical wastewater DOI Creative Commons
Yiyang Liang, Lihui Yang, Caiming Tang

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 25, 2025

Abstract Hundreds of per- and polyfluoroalkyl substances (PFAS) are present in fluorochemical production effluents, existing adsorption devices inadequate to address this PFAS challenge given their extreme structural diversity. Here, we achieve the broad-spectrum capture 107 from effluents using a treatment-train strategy that combines Zn-based electrocoagulation (EC) with anion-exchange resin (AER) beds. The “zero-carbon” adsorbent, zinc hydroxide flocs generated insitu by EC, bulk removes log K ow > 4 through semi-micellar mechanism similar mineral flotation achieves capacities at optimal level all reported adsorbents. Technical-economic analysis life-cycle environmental impact show coupling EC reduces cost an order-of-magnitude carbon-footprint 70% compared AER beds alone. It is also observed iodinated PFAS, some fluorine atoms replaced iodine atoms, exhibit significantly improved selectivity, which may shed light on designing environmentally-friendly fluorochemicals.

Язык: Английский

Процитировано

2
Gestational PFAS Exposure and Newborn Size: The Modifying Effect of Cord Blood Fatty Acids DOI Creative Commons
Chang Gao, Lin Luo,

Yijun Fan

и другие.

Environmental Science and Ecotechnology, Год журнала: 2024, Номер 22, С. 100476 - 100476

Опубликована: Авг. 3, 2024

Per- and polyfluoroalkyl substances (PFASs) can disrupt lipid metabolism, changes in cord blood fatty acid composition have been observed small newborns. Emerging evidence suggests that exposure to PFASs during pregnancy is linked decreased newborn size, although the not consistent. The modifying effect of acids on associations gestational PFAS with size still unknown. Here we show nutritional status fetus, as indicated by level blood, mitigates adverse effects newborn. Our study confirms developmental identifies emerging short-chain primary drivers reduced despite their lower burden compared legacy PFASs. Additionally, find protective role acids, suggesting potential strategies for mitigating detrimental environmental exposures human health. findings provide new toxicity call further evaluations these pollutants regulatory purposes. Future studies should consider complex interaction between nutrition within body, particularly first thousand days life, promote lifelong

Язык: Английский

Процитировано

5
Maternal per- and polyfluoroalkyl substances exposure, cord blood lipidomics and infant anthropometry: A mediation analysis DOI
Lan Yang,

Likang Li,

Honglei Ji

и другие.

Environmental Research, Год журнала: 2025, Номер 271, С. 121074 - 121074

Опубликована: Фев. 7, 2025

Язык: Английский

Процитировано

0
Accelerated placental aging mediated the association between prenatal exposure to per- and polyfluoroalkyl substances and small-for-gestational age newborns DOI

Yijun Fan,

Liyan Guo,

Chang Gao

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 299, С. 118338 - 118338

Опубликована: Май 22, 2025

Язык: Английский

Процитировано

0
Prenatal exposure to per- and polyfluoroalkyl substances and sex-specific associations with offspring adiposity at 10 years of age: Metabolic perturbation plays a role DOI Creative Commons
Zheng Wang, Boya Zhang, Jiming Zhang

и другие.

Environment International, Год журнала: 2024, Номер 192, С. 109037 - 109037

Опубликована: Сен. 25, 2024

Per- and polyfluoroalkyl substances (PFAS) have been suspected as potential environmental obesogens, with several mechanisms being proposed, including the role of metabolomics. However, current epidemiological studies yielded inconclusive findings.

Язык: Английский

Процитировано

3
Cord plasma metabolomic signatures of prenatal per- and polyfluoroalkyl substance (PFAS) exposures in the Boston birth Cohort DOI Creative Commons
Zeyu Li, Mingyu Zhang, Xiumei Hong

и другие.

Environment International, Год журнала: 2024, Номер 194, С. 109144 - 109144

Опубликована: Ноя. 15, 2024

Prenatal per- and polyfluoroalkyl substance (PFAS) exposures are associated with adverse offspring health outcomes, yet the underlying pathological mechanisms unclear. Cord blood metabolomics can identify potentially important pathways prenatal PFAS exposures, providing mechanistic insights that may help explain PFAS' long-term effects. The study included 590 mother-infant dyads from Boston Birth Cohort. We measured in maternal plasma samples collected 24-72 h after delivery metabolites cord samples. used metabolome-wide association studies pathway enrichment analyses to individual PFAS, quantile-based g-computation models examine associations of mixture. False Discovery Rate account for multiple comparisons. found 331 18 were ≥ 1 38 mixture, predominantly amino acids lipids. Amino such as alanine lysine their pathways, crucial energy generation, biosynthesis, bone health, effects on fetal growth restriction. Carnitines carnitine shuttle pathway, 7 involved mitochondrial fatty acid β-oxidation, which predispose higher risks child restriction cardiovascular diseases. Lipids, glycerophospholipids related contribute insulin resistance diabetes by modulating transporters cell membranes, participating β-cell signaling inducing oxidative damage. Neurotransmission-related including cofactors, precursors, neurotransmitters, neurodevelopment. observed stronger between males. This prospective birth cohort contributes limited literature potential metabolomic perturbations exposures. Future needed replicate our findings link outcomes.

Язык: Английский

Процитировано

3
Differential impact of perfluorooctanoic acid and fluorotelomer ethoxylates on placental metabolism in mice DOI Creative Commons
Haley M. Adams,

Jenna Hanrahan,

Sophie Kiefte

и другие.

Chemosphere, Год журнала: 2024, Номер 356, С. 141923 - 141923

Опубликована: Апрель 8, 2024

Язык: Английский

Процитировано

2
Early pregnancy serum PFAS are associated with alterations in the maternal lipidome DOI

Margaret H. Rabotnick,

Ariana Haidari,

Dana C. Dolinoy

и другие.

Environmental Research, Год журнала: 2024, Номер 263, С. 120183 - 120183

Опубликована: Окт. 18, 2024

Язык: Английский

Процитировано

2
Considerations for Measurements of Aggregate PFAS Exposure in Precision Environmental Health DOI Creative Commons
Katherine E. Manz

ACS Measurement Science Au, Год журнала: 2024, Номер 4(6), С. 620 - 628

Опубликована: Окт. 22, 2024

Per- and polyfluoroalkyl substances (PFAS) have become a major focus of research due to their widespread environmental presence adverse health effects associated with human exposure. PFAS include legacy emerging structures are characterized by range functional groups carbon–fluorine chains that vary in length (from fewer than 3 carbons more 7 carbons). Research has linked exposure an array concerns, ranging from developmental reproductive disorders immune system impairments increased risk certain cancers. In this new era personalized health, measuring markers biospecimens is important part public surveillance. typically measured blood tissues using targeted approaches, which quantify individual specific instrumentation. The diversity complexity PFAS, the limitations approaches sheer number structures, absence publicly available analytical standards pose significant challenges for measurement methodologies. This perspective aims describe aggregate measurements potential use precision medicine applications including discussion benefits these measurements. As organizations, healthcare professionals, look guidance regarding safe pragmatic cost-effective manner, dynamic field science poised respond innovative technological solutions need.

Язык: Английский

Процитировано

1
Associations of pre- and postnatal per- and polyfluoroalkyl substance exposure with adolescents’ eating behaviors DOI Creative Commons

Taylor-Marie Vasil,

Elvira S. Fleury, Erica D. Walker

и другие.

Environmental Epidemiology, Год журнала: 2024, Номер 8(5), С. e343 - e343

Опубликована: Сен. 26, 2024

Background: Per- and polyfluoroalkyl substances (PFAS), persistent environmental chemicals, may act as obesogens by interacting with neuroendocrine pathways regulating energy homeostasis satiety signals influencing adolescent eating behaviors. Methods: In 211 HOME Study adolescents (Cincinnati, OH; recruited 2003–2006), we measured PFAS concentrations in serum collected during pregnancy, at delivery, ages 3, 8, 12 years. Caregivers completed the Child Eating Behavior Questionnaire (CEBQ) age 12, calculated food approach avoidance scores. Using quantile-based g-computation, estimated covariate-adjusted associations between a mixture of four gestational CEBQ We identified high (n = 76, 36%) low 135, 64%) longitudinal exposure profiles delivery years using latent profile analysis related these to examined whether child sex or physical activity modified associations. Results: observed no association Children higher had slightly scores ( β : 0.47, 95% CI: −0.27, 1.23) similar −0.15, −0.75, 0.46) compared children lower profile. found some evidence that favorably emotional overeating (interaction P value 0.13). did not consistently modify any Conclusions: Serum were linked behaviors this study, suggesting alternative pathways, such metabolic rate, underlie previously childhood obesity.

Язык: Английский

Процитировано

0