Network-Based Identification of Key Toxic Compounds in Airborne Chemical Exposome
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Air
pollution
is
a
leading
contributor
to
the
global
disease
burden.
However,
complex
nature
of
chemicals
which
humans
are
exposed
through
inhalation
has
obscured
identification
key
compounds
responsible
for
diseases.
Here,
we
develop
network
topology-based
framework
identify
toxic
in
airborne
chemical
exposome.
Using
cardiovascular
diseases
(CVDs)
as
model
disease,
found
that
modules
various
closely
linked
CVDs.
The
proximity
compound
target
can
indicate
extent
toxicity
induced
by
compounds.
By
integrating
mass
spectrometry-based
external
exposure
concentrations
and
machine
learning-predicted
internal
concentrations,
established
comprehensive
linkage
connecting
disease-related
risk
These
findings
were
subsequently
validated
using
data
on
regional
scale.
This
work
provides
an
effective
strategy
identifying
within
environmental
exposomes
establishes
new
paradigm
understanding
pathogenicity
air
pollution.
Язык: Английский
Incorporating new approach methods (NAMs) data in dose–response assessments: The future is now!
Journal of Toxicology and Environmental Health Part B,
Год журнала:
2024,
Номер
unknown, С. 1 - 35
Опубликована: Окт. 10, 2024
Regulatory
dose–response
assessments
traditionally
rely
on
in
vivo
data
and
default
assumptions.
New
Approach
Methods
(NAMs)
present
considerable
opportunities
to
both
augment
traditional
accelerate
the
evaluation
of
new/data-poor
chemicals.
This
review
aimed
determine
potential
utilization
NAMs
through
a
unified
conceptual
framework
that
compartmentalizes
derivation
toxicity
values
into
five
sequential
Key
Dose–response
Modules
(KDMs):
(1)
point-of-departure
(POD)
determination,
(2)
test
system-to-human
(e.g.
inter-species)
toxicokinetics
(3)
toxicodynamics,
(4)
human
population
(intra-species)
variability
(5)
toxicokinetics.
After
using
several
"traditional"
dose-response
illustrate
this
framework,
is
presented
where
existing
NAMs,
including
silico,
vitro,
approaches,
might
be
applied
across
KDMs.
Further,
false
dichotomy
between
NAMs-derived
sources
broken
down
by
organizing
matrix
each
KDM
has
Tiers
increasing
precision
confidence:
Tier
0:
Default/generic
values,
1:
Computational
predictions,
2:
Surrogate
measurements,
3:
Direct
measurements.
These
findings
demonstrated
although
many
publications
promote
use
KDMs
for
POD
determination
toxicokinetics,
proposed
reveals
additional
immediate
integrated
other
critical
needs
were
identified
developing
improve
vitro
dosimetry
quantify
system
toxicodynamics.
Overall,
broadening
integration
steps
assessment
promises
yield
higher
throughput,
less
animal-dependent,
more
science-based
protecting
health.
Язык: Английский
Advancing quantitative hazard banding using expanded probabilistic reference doses and high-throughput screening data for preliminary hazard assessment
NAM journal.,
Год журнала:
2025,
Номер
1, С. 100014 - 100014
Опубликована: Янв. 1, 2025
Язык: Английский
Near-field exposures and human health impacts for organic chemicals in interior paints: A high-throughput screening
Journal of Hazardous Materials,
Год журнала:
2023,
Номер
465, С. 133145 - 133145
Опубликована: Дек. 12, 2023
Interior
paints
contain
organic
chemicals
that
might
be
harmful
to
painters
and
building
residents.
This
study
aims
develop
a
high-throughput
approach
screen
near-field
human
exposures
health
impacts
related
in
interior
paints.
We
developed
mass
balance
models
for
both
water-
solvent-based
paints,
predicting
emissions
during
wet
dry
phases.
then
screened
risks,
focusing
on
Sri
Lanka
where
residential
houses
are
frequently
repainted.
These
accurately
predict
paint
drying
time
indoor
air
concentrations
of
chemicals.
Exposures
painter
household
resident
were
estimated
65
water-based
26
considering
12
solvents.
Chemicals
concerns
(CoCs)
identified,
maximum
acceptable
chemical
contents
(MACs)
calculated.
Water-based
generally
pose
lower
risks
than
but
biocides
high
concern.
The
total
impact
one
painting
event
all
adults
ranges
from
1.5
×
10
Язык: Английский