Absence of a Causal Link between Elemental Carbon Exposure and Short-Term Respiratory Toxicity in Human-Derived Organoids and Cellular Models
Environmental Science & Technology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
Black
carbon
or
elemental
(EC)
in
the
atmosphere
plays
an
ambiguous
role
acute
respiratory
toxic
effects.
Here,
we
evaluate
contribution
of
EC
to
short-term
toxicity
(including
cytotoxicity
and
oxidative
stress
potency)
fine
particulate
matter
(PM2.5)
on
human
tract
using
vitro
airway
organoids
cell
lines.
The
potency
per
unit
mass,
including
char
soot,
is
more
than
2
orders
magnitude
lower
that
polycyclic
aromatic
hydrocarbons
(PAHs),
which
are
coemitted
from
incomplete
combustion.
contributes
approximately
1
order
less
PM2.5
PAHs,
despite
its
positive
associations
with
PM2.5-induced
(p
<
0.0001).
Furthermore,
PAHs
contribute
71.9
±
12.2%
61.9
32.8%
overall
emitted
typical
burning
solid
liquid
fuels,
respectively,
while
significantly
correlates
content
(r
=
0.94,
p
0.002).
Hence,
not
a
cause
inducing
toxicity,
likely
attributed
PAHs.
These
findings
provide
causal
evidence
for
understanding
health
risks
associated
exposure
further
benefit
establishing
efficient
air
pollution
control
policies.
Язык: Английский
Variations in polycyclic aromatic hydrocarbons concentrations and their contribution to aerosol optical depth during the COVID-19 outbreak: A study in Yokohama using generalized additive model
Atmospheric Pollution Research,
Год журнала:
2025,
Номер
16(8), С. 102547 - 102547
Опубликована: Апрель 16, 2025
Язык: Английский
A solid-state infrared laser for two-step desorption–ionization processes in single-particle mass spectrometry
Atmospheric measurement techniques,
Год журнала:
2025,
Номер
18(11), С. 2425 - 2437
Опубликована: Июнь 5, 2025
Abstract.
Recent
advancements
in
single-particle
mass
spectrometry
(SPMS)
have
enabled
the
detection
of
aromatic
hydrocarbons
at
individual
particle
level
conjunction
with
inorganic/refractory
components.
However,
laser
desorption
(LD)
organic
material
from
particles
prior
to
their
ionization
a
two-step
process
necessitates
pulsed
infrared
lasers
adequate
pulse
energy
that
can
be
irregularly
triggered
on
detected
particles.
Pulsed
CO2
10.6
µm
wavelength
been
traditionally
utilized,
yet
these
are
bulky
and
costly
require
regular
maintenance,
including
gas
exchange
or
continuous
supply.
In
this
study,
we
present
application
prototype
solid-state
based
an
erbium-doped
yttrium
aluminum
garnet
(Er:YAG)
crystal,
emitting
long
pulses
200
µs
3
as
compact,
cost-effective,
user-friendly
alternative
for
LD.
We
directly
compared
new
commonly
used
found
similar
performance
LD
both
laboratory
ambient
air
experiments.
With
exception
slightly
increased
fragmentation
observed
due
its
beam
profile,
no
qualitative
differences
were
noted
resulting
spectra.
Additionally,
novel
(LD-REMPI–LDI)
conventional
single-step
LDI
regarding
potential
detect
polycyclic
(PAHs)
inorganics
field
The
combined
methods
demonstrated
superior
PAHs,
Er:YAG
laser.
addition
higher
sensitivity
lower
PAHs
when
LDI,
it
is
less
dependent
matrix,
sharing
benefits
traditional
but
extending
capability
combine
PAH
measurements
LDI-based
inorganic
compounds.
Язык: Английский
Oxidation of Polycyclic Aromatic Hydrocarbons (PAHs) Triggered by a Photochemical Synergistic Effect between High- and Low-Molecular-Weight PAHs
Environmental Science & Technology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 30, 2024
Photooxidation
of
polycyclic
aromatic
hydrocarbons
(PAHs),
which
are
widely
observed
in
atmospheric
particulate
matter
(PM),
largely
determines
their
fate.
In
the
environment,
PAHs
highly
complex
chemical
composition,
and
a
great
variety
tend
to
co-occur.
Despite
extensive
investigation
on
photochemical
behavior
individual
PAH
molecules,
interaction
among
these
coexisting
is
still
not
well
understood.
Here,
we
show
that
during
photooxidation,
there
strong
synergistic
effect
extracted
from
soot
particles.
We
find
neither
small
with
low
molecular
weights
200-350
Da
4-8
rings
(named
Язык: Английский