JTCD attenuates HF by inhibiting activation of HSCs through PPARα-TFEB axis-mediated lipophagy
Phytomedicine,
Год журнала:
2025,
Номер
139, С. 156501 - 156501
Опубликована: Фев. 12, 2025
Язык: Английский
Environmental Chemical-Induced Cardiometabolic Disorders: Combined Epidemiological and Experimental Evidence
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 20, 2025
Screening
environmental
pollutants
that
are
harmful
to
the
cardiometabolic
status
and
understanding
their
key
toxic
pathways
crucial
for
effective
clinical
intervention.
Based
on
exposure
data
of
46
chemicals
in
a
nationally
representative
13,286
people,
logistic
regression
mixture
modeling
were
used
preliminarily
identify
with
significant
impacts
12
indicators
disorders.
A
total
15
found
be
associated
integrated
latent
class,
among
which
four
(perfluorononanoic
acid
[PFNA],
perfluorooctanoic
[PFOA],
thiocyanate,
thallium)
also
contributed
significantly
effect.
We
constructed
adverse
outcome
(AOPs)
nine
toxicants
both
models
individual
each
disorder.
Notably,
fluoroalkyl
substances
affect
multiple
aspects
hyperlipidemia
by
activating
PPARα.
performed
molecular
docking
vitro
experiments
verify
supplement
toxicological
mechanism
PFNA.
Through
binding
PPARα,
PFNA
increased
levels
downstream
molecules
including
CD36
(fatty
transfer),
ACSL1
activation),
CPT1a
(intracellular
transfer
β-oxidation)
ultimately
promoted
accumulation
triglycerides
lipid
droplets
HepG2
cells.
These
markers,
together
events
other
metabolic
phenotypes,
may
potential
targets
scientific
research
or
treatment.
Язык: Английский
6:2 Fluorotelomer Ethoxylates in Human Serum and Residential Homes: A Growing Environmental Health Concern
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
As
an
emerging
group
of
per-
and
polyfluoroalkyl
substances
(PFAS),
fluorotelomer
ethoxylates
(FTEOs)
are
widely
employed
as
a
major
ingredient
in
antifog
products.
However,
knowledge
about
their
environmental
distribution
human
exposure
remains
scarce.
Herein,
we
reported
the
ubiquitous
detection
6:2
FTEO
homologues
popular
products
(n
=
47),
indoor
dust
from
residential
homes
80),
serum
pregnant
women
90)
living
South
China,
demonstrating
broad
use
widespread
exposure.
The
cumulative
concentrations
FTEOs
ranged
below
limit
(
Язык: Английский
Age-specific associations between per- and polyfluoroalkyl substances exposure and metabolic syndrome: a cross-sectional study
Luanxun Lin,
Xiaoqin Lin,
Shuaidan Chang
и другие.
Lipids in Health and Disease,
Год журнала:
2025,
Номер
24(1)
Опубликована: Май 10, 2025
The
widespread
presence
of
per-and
polyfluoroalkyl
substances
(PFAS)
has
raised
global
health
concerns.
This
study
aims
to
determine
the
age-specific
relationships
PFAS
compounds
with
metabolic
syndrome
(MetS)
and
its
components.
We
used
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
in
2003-2018.
Modified
Poisson
regression
was
employed
estimate
associations
between
individual
prevalence
MetS,
as
well
Multiple
linear
analyses
were
performed
examine
congeners
markers,
including
lipid
glucose
homeostasis
traits.
Additionally,
weighted
quantile
sum
(WQS)
Bayesian
kernel
machine
(BKMR)
models
conducted
investigate
joint
effects
mixtures
on
MetS
components
across
different
age
groups.
A
total
5850
participants
included
for
analysis.
In
model,
ln-transformed
perfluorononanoic
acid
(PFNA)
level
positively
correlated
adolescents
(prevalence
ratio
[PR]
=
1.42;
95%
CI:
1.01-1.99).
Conversely,
perfluorohexanesulfonic
(PFHxS)
2-(N-Methylperfluorooctane
sulfonamido)
acetic
(MeFOSAA)
negatively
associated
risks
young
adults
(PR
0.86,
0.76-0.98)
middle-aged
0.88,
0.79-0.98),
respectively.
Notably,
exposure
levels
cholesterol,
low-density
lipoprotein,
non-high-density
high-density
lipoprotein
adults.
However,
overall
effect
using
WQS
BKMR
showed
no
significant
mixture
any
group.
Nonetheless,
adults,
adversely
hypertriglyceridemia
linked
a
greater
risk
hypertension
increased
cholesterol
levels.
Our
highlighted
complex
Co-exposure
particularly
dyslipidemia
Prospective
studies
are
needed
better
comprehension
causative
impact
MetS.
Язык: Английский
Perfluorohexanesulfonic Acid (PFHxS) Induces Hepatotoxicity through the PPAR Signaling Pathway in Larval Zebrafish (Danio rerio)
Environmental Science & Technology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
In
recent
years,
the
industrial
substitution
of
long-chain
per-
and
polyfluoroalkyl
substances
(PFAS)
with
short-chain
alternatives
has
become
increasingly
prevalent,
resulting
in
widespread
environmental
detection
perfluorohexanesulfonic
acid
(PFHxS),
a
PFAS.
However,
there
remains
limited
information
about
potential
adverse
effects
PFHxS
at
concentrations
to
wildlife.
Here,
early
life
stage
zebrafish
(
Язык: Английский
Serum levels of Per- and poly-fluoroalkyl substances among middle-aged and elderly populations in Beijing and their association with dyslipidemia
Food and Chemical Toxicology,
Год журнала:
2024,
Номер
unknown, С. 115066 - 115066
Опубликована: Окт. 1, 2024
Язык: Английский
Fluorinated liquid crystal monomer (FLCM) induces kidney dysfunction by disrupting PPARα-mediated fatty acid oxidation: In vivo, in vitro, and in silico assays
Environmental Chemistry and Ecotoxicology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Язык: Английский