Effects of a Novel Estrogenic Perfluoroalkyl Substance on Reproductive Endocrinology and Function in the Fathead Minnow (Pimephales promelas) DOI Creative Commons
Gerald T. Ankley,

Kathleen Jensen,

Jenna E. Cavallin

и другие.

Environmental Toxicology and Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Effects data are lacking for the majority of poly- and perfluoroalkyl substances (PFAS). Recent in vitro work with around 140 data-poor PFAS showed that several could affect signaling pathways associated estrogen receptor-α (ER). Subsequent short-term gene expression studies adult male fathead minnows (Pimephales promelas) using a subset ER-active confirmed their estrogenic properties vivo. Herein, we evaluated effects most potent these, 1H, 10H, 10H-perfluorodecane-1,10-diol (FC10-diol), multi-endpoint minnow reproduction assay designed endocrine-disrupting chemicals. Fish were exposed 21 days to five water concentrations FC10-diol, ranging from 0.68 68 µg/L, or 17β-estradiol as positive control. Data FC10-diol an ER agonist. Responses males included changes four hepatic genes controlled by ER, induction plasma vitellogenin (VTG; egg yolk protein precursor), decreased secondary sexual characteristics, histopathological testis kidney, mortality highest treatment group. females high altered ovarian involved steroid synthesis, steroids, elevated VTG, histological ovary production. In addition generating baseline toxicological data, study results enabled evaluation expansion two adverse outcome (AOPs) predicting agonists fish. One AOPs links activation abnormal production resulting kidney dysfunction death, whereas second connects gonadotropin signaling, synthesis maturation-inducing steroids consequent on oocyte development release.

Язык: Английский

PFAS self-assembly and adsorption dynamics on graphene: molecular insights into chemical and environmental influences DOI Creative Commons
Bradley G. Lamb, Boran Ma

Nanoscale, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This study offers atomistic insights into the adsorption of per- and polyfluoroalkyl substances (PFAS) on graphene, highlighting how stability adsorbed PFAS is influenced by fluoroalkyl chain length, headgroup characteristic, pH condition.

Язык: Английский

Процитировано

0
Effects of a Novel Estrogenic Perfluoroalkyl Substance on Reproductive Endocrinology and Function in the Fathead Minnow (Pimephales promelas) DOI Creative Commons
Gerald T. Ankley,

Kathleen Jensen,

Jenna E. Cavallin

и другие.

Environmental Toxicology and Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Effects data are lacking for the majority of poly- and perfluoroalkyl substances (PFAS). Recent in vitro work with around 140 data-poor PFAS showed that several could affect signaling pathways associated estrogen receptor-α (ER). Subsequent short-term gene expression studies adult male fathead minnows (Pimephales promelas) using a subset ER-active confirmed their estrogenic properties vivo. Herein, we evaluated effects most potent these, 1H, 10H, 10H-perfluorodecane-1,10-diol (FC10-diol), multi-endpoint minnow reproduction assay designed endocrine-disrupting chemicals. Fish were exposed 21 days to five water concentrations FC10-diol, ranging from 0.68 68 µg/L, or 17β-estradiol as positive control. Data FC10-diol an ER agonist. Responses males included changes four hepatic genes controlled by ER, induction plasma vitellogenin (VTG; egg yolk protein precursor), decreased secondary sexual characteristics, histopathological testis kidney, mortality highest treatment group. females high altered ovarian involved steroid synthesis, steroids, elevated VTG, histological ovary production. In addition generating baseline toxicological data, study results enabled evaluation expansion two adverse outcome (AOPs) predicting agonists fish. One AOPs links activation abnormal production resulting kidney dysfunction death, whereas second connects gonadotropin signaling, synthesis maturation-inducing steroids consequent on oocyte development release.

Язык: Английский

Процитировано

0