
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Ноя. 7, 2024
Abstract Antimicrobial resistance (AMR) represents a critical global health challenge, exacerbated by the proliferation of genes in wastewater environments. This study introduces novel Resistance Persistence Index (RPI) that integrates existing risk assessment frameworks with persistence and mobility metrics antimicrobial (ARGs) treatment plant (WWTP) influent. We evaluated samples collected across wet dry seasons, focusing on dynamics ARG diversity, abundance, their associations human impact. Our findings indicate significant increase unique ARGs during season, “antibiotic inactivation” as predominant mechanism. Using Zhang et al.’s ranking framework, we assessed levels various ARGs, revealing while fewer high-risk were identified, they demonstrated substantial abundance. The RPI provided insights into how combined effects influence associated different families. integrated framework offers comprehensive tool for understanding managing AMR environmental settings, guiding future surveillance intervention strategies.
Язык: Английский