bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 30, 2024
Abstract
Per-
and
polyfluorinated
alkyl
substances
(PFAS)
are
pervasive
environmental
contaminants
that
bioaccumulate
in
tissues
pose
risks
to
human
health.
Increasing
evidence
links
PFAS
neurodegenerative
behavioral
disorders,
yet
the
underlying
mechanisms
of
their
effects
on
neuronal
function
remain
largely
unexplored.
In
this
study,
we
utilized
SH-SY5Y
neuroblastoma
cells,
differentiated
into
neuronal-like
investigate
impact
six
compounds—
perfluorooctanoic
acid
(PFOA),
perfluorooctanesulfonic
(PFOS),
perfluorodecanoic
(PFDA),
perfluorodecanesulfonic
(PFDS),
8:2
fluorotelomer
sulfonate
(8:2
FTS),
alcohol
FTOH)—on
Following
a
30
μM
exposure
for
24
hours,
accumulation
ranged
from
100–7500
ng/mg
protein.
Transcriptomic
analysis
revealed
721
differentially
expressed
genes
(DEGs)
across
treatments
(p
adj
<
0.05),
with
11
DEGs
shared
among
all
exposures,
indicating
potential
biomarkers
toxicity.
PFOA-treated
cells
showed
downregulation
involved
synaptic
growth
neural
function,
while
PFOS,
PFDS,
FTS,
FTOH
exposures
resulted
upregulation
related
hypoxia
response
amino
metabolism.
Lipidomic
profiling
further
demonstrated
significant
fatty
PFDA,
alongside
triacylglycerol
FTOH.
These
findings
suggest
neurotoxic
structurally
dependent,
offering
insights
molecular
processes
may
drive
PFAS-induced
dysfunction.
Synopsis
poly
fluorinated
have
been
shown
affect
This
study
aims
provide
specific
biological
through
which
affects
cells.
Chemosphere,
Год журнала:
2024,
Номер
370, С. 143859 - 143859
Опубликована: Дек. 12, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS),
often
termed
"forever
chemicals,"
are
a
diverse
group
of
persistent
fluorinated
compounds,
including
the
well-known
perfluorooctanesulfonic
acid
(PFOS),
which
has
been
identified
as
lethal
to
bee
larvae.
However,
risk
PFAS
exposure
through
pollen,
bee's
primary
food
source,
not
thoroughly
investigated.
In
controlled
greenhouse
experiments,
Cannabis
sativa
L.
(hemp)
plants
were
cultivated
in
soil
contaminated
with
eight
compounds.
Phytoremediation
potential
was
assessed
by
measuring
bioconcentration
factors
(BCF)
both
total
above-ground
biomass
pollen.
The
study
found
that
BCF
for
hemp
pollen
significant
(>20.8),
over
45%
uptake
around
3,248
μg/kg
concentrated
Based
on
these
figures,
estimated
daily
intake
(EDI)
PFOS
western
honeybees
(Apis
mellifera)
be
about
124.5
body
weight
per
day.
These
findings
underscore
critical
global
threat
pollinator
health,
implications
agriculture
biodiversity.
Environmental Toxicology and Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
Abstract
Surface
water
concentrations
of
per-
and
polyfluoroalkyl
substances
(PFAS)
potential
for
resulting
biological
effects
were
estimated
in
a
study
using
Polar
Organic
Chemical
Integrative
Samplers
(POCIS)
from
60
tributary
sites
within
20
watersheds
the
Great
Lakes
Basin
2018.
Sites
represented
range
urban
to
agricultural,
forested,
wetland
land
uses
included
gradient
wastewater
treatment
effluent
zero
44%
annual
streamflow.
Several
also
had
airport
influence.
Twenty-one
32
targeted
PFAS
compounds
detected
POCIS
samplers,
which,
16
available
sampling
rates
enabling
time-weighted
concentration
estimates
comparison
with
data.
Estimated
compared
published
quality
guidelines
(available
nine
PFAS),
effect
reported
primary
literature
ECOTOX
Knowledgebase
apical
endpoints
(10
PFAS)
non-apical
vitro
high-throughput
screening
data
ToxCast
(14
PFAS).
Based
on
conservative
evaluation
approach
that
was
weighted
persistence
limitations
toxicological
information,
five
individual
PFAS,
including
Perfluorooctanesulfonic
acid,
Perfluorohexanesulfonic
Perfluorobutanesulfonic
Perfluorooctanoic
Perfluorononanoic
acid
identified
as
warranting
additional
investigation.
Possible
increased
potency
mixtures
over
chemical
effects,
by
summation
exposure-activity
ratios
(EARs)
chemicals
influence
common
assays
specified
gene
targets,
indicated
EAR
values
up
5.6-fold
14
contributing
mixture
predictions.
Potential
summed
ratios,
correlated
use
proportion
streamflow
contributed
effluent.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
Acute
exposure
studies
have
reported
that
chemical
speciation
significantly
affects
the
developmental
toxicity
of
perfluoroalkyl
acids
(PFAAs).
However,
mechanisms
underlying
chronic
PFAAs
as
a
function
remain
unknown.
With
an
aim
to
gain
more
insights
into
PFAA
structure-toxicity
relationship,
this
study
exposed
adult
zebrafish
and
salts
perfluorooctanoate
(PFOA),
perfluorobutanoate
(PFBA),
perfluorobutanesulfonate
(PFBS)
at
environmentally
realistic
concentrations
for
5
months.
In
F0
generation,
induced
hypothyroidism
symptoms
potently
than
their
salt
counterparts.
After
parental
exposure,
speciation-dependent
transfer
behavior
was
noted,
with
greater
burden
in
offspring.
Similarly,
were
associated
higher
risks
transgenerational
defects
thyroid
dysfunction
during
offspring
embryogenesis.
bound
receptor
beta
(TRβ)
strongly
salts.
An
antagonistic
interaction
PFOA
PFBS
TR
activity
observed
vitro
via
reduction
TRβ
accessibility
target
genes.
CUT&Tag
sequencing
revealed
disturbances
due
on
genomic
profile
TRβ,
indicating
interfere
multiple
thyroidal
nervous
processes.
conclusion,
current
findings
provided
evidence
regarding
critical
effects
toxicity,
highlighting
need
perform
discriminative
risk
assessment
management.
Chemosphere,
Год журнала:
2025,
Номер
377, С. 144301 - 144301
Опубликована: Апрель 9, 2025
Public
concern
over
per-
and
polyfluoroalkyl
substances
(PFAS)
continues
to
grow
as
evidence
highlights
their
persistence,
bioaccumulation
potential,
adverse
health
effects.
Increasing
detections
in
drinking
water,
consumer
products,
industrial
discharges
have
intensified
regulatory
scrutiny.
This
review
examines
the
evolving
PFAS
landscape
United
States,
focusing
on
pulp,
paper,
textiles
industries,
which
contribute
significantly
contamination
through
wastewater
discharges,
end-product
disposal,
absence
of
dedicated
removal
technologies.
emissions
from
food
packaging
alone
are
estimated
at
2,300
kg
annually.
Addressing
presents
substantial
economic
challenges,
with
treatment
costs
projected
reach
USD
3
billion
annually
growing
risks
legal
liabilities
exemplified
by
paper
mill
settlements
reaching
11.9
million
for
historical
pollution.
Large-scale
remediation
remains
financially
prohibitive,
estimates
exceeding
global
gross
domestic
product
(GDP)
106
trillion.
Additionally,
healthcare
PFAS-linked
diseases
exceed
62
further
emphasize
need
prevention.
State-level
restrictions
PFAS-containing
products
expanding,
particularly
textiles,
now
most
regulated
across
States.
As
face
increasing
market
limitations
potential
loss
sustainability
certifications,
already
reduced
sales
growth
70%
some
cases,
transitioning
non-fluorinated
alternatives
could
mitigate
companies.
Within
this
context,
urgency
integrating
policy,
technological
innovation,
incentives
accelerate
transition
away
long-term
environmental
financial
liabilities.