Transcriptomics effects of per- and polyfluorinated alkyl substances in differentiated neuronal cells DOI Open Access
Logan Running,

Judith R. Cristobal,

Charikleia Karageorgiou

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 30, 2024

Abstract Per- and polyfluorinated alkyl substances (PFAS) are pervasive environmental contaminants that bioaccumulate in tissues pose risks to human health. Increasing evidence links PFAS neurodegenerative behavioral disorders, yet the underlying mechanisms of their effects on neuronal function remain largely unexplored. In this study, we utilized SH-SY5Y neuroblastoma cells, differentiated into neuronal-like investigate impact six compounds— perfluorooctanoic acid (PFOA), perfluorooctanesulfonic (PFOS), perfluorodecanoic (PFDA), perfluorodecanesulfonic (PFDS), 8:2 fluorotelomer sulfonate (8:2 FTS), alcohol FTOH)—on Following a 30 μM exposure for 24 hours, accumulation ranged from 100–7500 ng/mg protein. Transcriptomic analysis revealed 721 differentially expressed genes (DEGs) across treatments (p adj < 0.05), with 11 DEGs shared among all exposures, indicating potential biomarkers toxicity. PFOA-treated cells showed downregulation involved synaptic growth neural function, while PFOS, PFDS, FTS, FTOH exposures resulted upregulation related hypoxia response amino metabolism. Lipidomic profiling further demonstrated significant fatty PFDA, alongside triacylglycerol FTOH. These findings suggest neurotoxic structurally dependent, offering insights molecular processes may drive PFAS-induced dysfunction. Synopsis poly fluorinated have been shown affect This study aims provide specific biological through which affects cells.

Язык: Английский

Liquid and gas-chromatography-mass spectrometry methods for exposome analysis DOI
Victor Castro‐Alves, Nguyễn Hoàng Anh, João Marcos G. Barbosa

и другие.

Journal of Chromatography A, Год журнала: 2025, Номер unknown, С. 465728 - 465728

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2

Multigeneration responses of Daphnia magna to short-chain per- and polyfluorinated substances (PFAS) DOI
Ge Xie, Cornelis A.M. van Gestel, J. Arie Vonk

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 294, С. 118078 - 118078

Опубликована: Март 23, 2025

Язык: Английский

Процитировано

2

PFAS biodegradation by Labrys portucalensis F11: Evidence of chain shortening and identification of metabolites of PFOS, 6:2 FTS, and 5:3 FTCA DOI
Mindula K. Wijayahena, Irina S. Moreira, Paula M. L. Castro

и другие.

The Science of The Total Environment, Год журнала: 2025, Номер 959, С. 178348 - 178348

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1

Phytoremediation evaluation of forever chemicals using hemp (Cannabis sativa L.): Pollen bioaccumulation and the risk to bees DOI Creative Commons
Timothy Wright, Marcus Crompton, Daniel T. Bishop

и другие.

Chemosphere, Год журнала: 2024, Номер 370, С. 143859 - 143859

Опубликована: Дек. 12, 2024

Per- and polyfluoroalkyl substances (PFAS), often termed "forever chemicals," are a diverse group of persistent fluorinated compounds, including the well-known perfluorooctanesulfonic acid (PFOS), which has been identified as lethal to bee larvae. However, risk PFAS exposure through pollen, bee's primary food source, not thoroughly investigated. In controlled greenhouse experiments, Cannabis sativa L. (hemp) plants were cultivated in soil contaminated with eight compounds. Phytoremediation potential was assessed by measuring bioconcentration factors (BCF) both total above-ground biomass pollen. The study found that BCF for hemp pollen significant (>20.8), over 45% uptake around 3,248 μg/kg concentrated Based on these figures, estimated daily intake (EDI) PFOS western honeybees (Apis mellifera) be about 124.5 body weight per day. These findings underscore critical global threat pollinator health, implications agriculture biodiversity.

Язык: Английский

Процитировано

3

Potential for biological effects of per- and polyfluoroalkyl substances (PFAS) in Great Lakes tributaries and associations with land cover and wastewater effluent DOI Creative Commons
Steven R. Corsi, Luke C. Loken, Gerald T. Ankley

и другие.

Environmental Toxicology and Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Abstract Surface water concentrations of per- and polyfluoroalkyl substances (PFAS) potential for resulting biological effects were estimated in a study using Polar Organic Chemical Integrative Samplers (POCIS) from 60 tributary sites within 20 watersheds the Great Lakes Basin 2018. Sites represented range urban to agricultural, forested, wetland land uses included gradient wastewater treatment effluent zero 44% annual streamflow. Several also had airport influence. Twenty-one 32 targeted PFAS compounds detected POCIS samplers, which, 16 available sampling rates enabling time-weighted concentration estimates comparison with data. Estimated compared published quality guidelines (available nine PFAS), effect reported primary literature ECOTOX Knowledgebase apical endpoints (10 PFAS) non-apical vitro high-throughput screening data ToxCast (14 PFAS). Based on conservative evaluation approach that was weighted persistence limitations toxicological information, five individual PFAS, including Perfluorooctanesulfonic acid, Perfluorohexanesulfonic Perfluorobutanesulfonic Perfluorooctanoic Perfluorononanoic acid identified as warranting additional investigation. Possible increased potency mixtures over chemical effects, by summation exposure-activity ratios (EARs) chemicals influence common assays specified gene targets, indicated EAR values up 5.6-fold 14 contributing mixture predictions. Potential summed ratios, correlated use proportion streamflow contributed effluent.

Язык: Английский

Процитировано

0

Assessing the Impact of Per- and Polyfluoroalkyl Substances on Pregnancy Loss: An Environmental-Wide Association Study in Northwest China DOI

Ling Liu,

Cai Liu, Wei Zhang

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Determination of Perfluoroalkyl Carboxylic Acids in Mice Serum and Tissue by Dispersive Solid-Phase Extraction Based on Fluorine-Functionalized Covalent Organic Frameworks Coupled with UPLC-MS/MS DOI

Jinni Zhang,

Shengtao Li, Xiaojing Li

и другие.

Journal of Chromatography A, Год журнала: 2025, Номер 1747, С. 465820 - 465820

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

0

Effects of Chemical Speciation on Chronic Thyroid Toxicity of Representative Perfluoroalkyl Acids DOI
Jing Li, Qi Wang, Chenyan Hu

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Acute exposure studies have reported that chemical speciation significantly affects the developmental toxicity of perfluoroalkyl acids (PFAAs). However, mechanisms underlying chronic PFAAs as a function remain unknown. With an aim to gain more insights into PFAA structure-toxicity relationship, this study exposed adult zebrafish and salts perfluorooctanoate (PFOA), perfluorobutanoate (PFBA), perfluorobutanesulfonate (PFBS) at environmentally realistic concentrations for 5 months. In F0 generation, induced hypothyroidism symptoms potently than their salt counterparts. After parental exposure, speciation-dependent transfer behavior was noted, with greater burden in offspring. Similarly, were associated higher risks transgenerational defects thyroid dysfunction during offspring embryogenesis. bound receptor beta (TRβ) strongly salts. An antagonistic interaction PFOA PFBS TR activity observed vitro via reduction TRβ accessibility target genes. CUT&Tag sequencing revealed disturbances due on genomic profile TRβ, indicating interfere multiple thyroidal nervous processes. conclusion, current findings provided evidence regarding critical effects toxicity, highlighting need perform discriminative risk assessment management.

Язык: Английский

Процитировано

0

Assessing the impact of per- and polyfluoroalkyl substances on pregnancy loss: An environmental-wide association study in Northwest China DOI

Ling Liu,

Cai Liu, Wei Zhang

и другие.

International Journal of Hygiene and Environmental Health, Год журнала: 2025, Номер 266, С. 114568 - 114568

Опубликована: Март 29, 2025

Язык: Английский

Процитировано

0

PFAS regulations and economic impact: A review of U.S. pulp & paper and textiles industries DOI Creative Commons

Mariana Lendewig,

Ronald Márquez,

Jorge Franco

и другие.

Chemosphere, Год журнала: 2025, Номер 377, С. 144301 - 144301

Опубликована: Апрель 9, 2025

Public concern over per- and polyfluoroalkyl substances (PFAS) continues to grow as evidence highlights their persistence, bioaccumulation potential, adverse health effects. Increasing detections in drinking water, consumer products, industrial discharges have intensified regulatory scrutiny. This review examines the evolving PFAS landscape United States, focusing on pulp, paper, textiles industries, which contribute significantly contamination through wastewater discharges, end-product disposal, absence of dedicated removal technologies. emissions from food packaging alone are estimated at 2,300 kg annually. Addressing presents substantial economic challenges, with treatment costs projected reach USD 3 billion annually growing risks legal liabilities exemplified by paper mill settlements reaching 11.9 million for historical pollution. Large-scale remediation remains financially prohibitive, estimates exceeding global gross domestic product (GDP) 106 trillion. Additionally, healthcare PFAS-linked diseases exceed 62 further emphasize need prevention. State-level restrictions PFAS-containing products expanding, particularly textiles, now most regulated across States. As face increasing market limitations potential loss sustainability certifications, already reduced sales growth 70% some cases, transitioning non-fluorinated alternatives could mitigate companies. Within this context, urgency integrating policy, technological innovation, incentives accelerate transition away long-term environmental financial liabilities.

Язык: Английский

Процитировано

0