The difference of organophosphate esters (OPEs) uptake, translocation and accumulation mechanism between four varieties in Poaceae
Journal of Plant Physiology,
Год журнала:
2025,
Номер
305, С. 154418 - 154418
Опубликована: Янв. 1, 2025
Язык: Английский
Underlying mechanisms of metabolic dysfunction-associated steatotic liver disease induced by 2-ethylhexyl diphenyl phosphate and its hydroxylated metabolite in zebrafish (Danio rerio)
Journal of Hazardous Materials,
Год журнала:
2025,
Номер
493, С. 138407 - 138407
Опубликована: Апрель 24, 2025
Язык: Английский
Aryl Organophosphate Esters and Hemostatic Disruption: Identifying Risk through Machine Learning and Experimental Validation
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 20, 2025
Organophosphate
esters
(OPEs)
have
emerged
as
a
significant
environmental
concern
due
to
their
widespread
occurrence
and
potential
human
health
risks.
The
presence
of
OPEs
in
blood
suggests
direct
interactions
with
hematological
components,
which
may
compromise
hemostatic
balance
lead
adverse
outcomes.
Despite
the
critical
role
maintaining
stability,
effects
on
this
system
remain
poorly
understood.
This
investigation
was
undertaken
delineate
mechanisms
that
modulate
hemostasis,
utilizing
silico
approach
high-throughput
vitro
investigation.
We
analyzed
85
environmentally
prevalent
for
structural
descriptors
affinity
proteins
essential
function.
multiple
linear
regression
implicated
aryl-OPEs,
distinguished
by
benzene
ring
scaffold,
potent
disruptors
balance.
analysis
result
rigorously
validated
through
assays.
Further
network
toxicology,
artificial
intelligence
(α-Fold)
algorithms,
an
agonist
cotreatment
assay
revealed
proliferator-activated
receptor
γ
(PPARγ)
key
mediator
aryl-OPEs
induced
disruption.
By
integrating
experimental
insights
vivo
exposure
data,
we
concluded
specific
such
bisphenol
bis
(diphenyl
phosphate)
(BDP)
cresyl
diphenyl
phosphate
(CDP),
pose
moderate
risk
general
population.
Our
findings
not
only
contribute
prioritization
management
but
also
establish
methodology
assessing
toxicity
emerging
pollutants.
Язык: Английский
Development and Characterization of a Standardized Adipogenesis Assay for Testing Metabolism Disrupting Chemicals Using Human Bone Marrow Derived Mesenchymal Stem Cells
NAM journal.,
Год журнала:
2025,
Номер
unknown, С. 100029 - 100029
Опубликована: Май 1, 2025
Язык: Английский