Journal of Hazardous Materials, Год журнала: 2025, Номер 494, С. 138743 - 138743
Опубликована: Май 27, 2025
Язык: Английский
Journal of Hazardous Materials, Год журнала: 2025, Номер 494, С. 138743 - 138743
Опубликована: Май 27, 2025
Язык: Английский
Water Research, Год журнала: 2025, Номер 277, С. 123310 - 123310
Опубликована: Фев. 17, 2025
Язык: Английский
Процитировано
0Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 298, С. 118273 - 118273
Опубликована: Май 8, 2025
Язык: Английский
Процитировано
0The Science of The Total Environment, Год журнала: 2025, Номер 985, С. 179668 - 179668
Опубликована: Май 27, 2025
The widespread application of per- and polyfluoroalkyl substances (PFAS) resulted in ubiquitous environmental contamination. Understanding the PFAS tissue distribution mammals humans is crucial for assessment potential health risks. levels eleven were determined by UPLC-MS/MS plasma various tissues wild boar (n = 82) hunted Germany. most prevalent (PFOA, PFNA, PFHxS PFOS) detected all analyzed samples. median level sum (Σ 4PFAS) was highest liver (90.2 μg/kg), followed kidney (9.45 (7.63 μg/L), lung (6.84 heart muscle (2.60 spleen (2.46 skeletal (1.03 μg/kg). Consumption a single portion (125 g) containing Σ 4PFAS would result 36.6-fold exceedance tolerable weekly intake (TWI) EFSA 70 kg-person. accumulation (calculated as tissue/plasma ratio) perfluoroalkyl carboxylic acids with ηpfc 8-13 lung, spleen, increased molecule size, indicating passive mechanisms driven hydrophobicity. In contrast, coefficients scattered, additional involvement chain-length dependent active transport processes. observed PFOS (median ratio 18.0). shortest included study (PFHxA, PFHpA, PFOA, PFBS PFHxS) did not accumulate any tissues, probably due to strong binding blood proteins like serum albumin their relative polarity impeding membrane diffusion.
Язык: Английский
Процитировано
0Journal of Hazardous Materials, Год журнала: 2025, Номер 494, С. 138743 - 138743
Опубликована: Май 27, 2025
Язык: Английский
Процитировано
0