6-PPD quinone causes alteration in ubiquinone-mediated complex III associated with toxicity on mitochondrial function and longevity in Caenorhabditis elegans

Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 116571 - 116571

Опубликована: Апрель 1, 2025

Язык: Английский

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Long-Term Exposure to 6-PPD Quinone Inhibits Glutamate Synthesis and Glutamate Receptor Function Associated with Its Toxicity Induction in Caenorhabditis elegans

Toxics, Год журнала: 2025, Номер 13(6), С. 434 - 434

Опубликована: Май 26, 2025

6-PPD quinone (6-PPDQ) is widely distributed in environments. In Caenorhabditis elegans, we first examined the effects of 6-PPDQ on glutamate synthesis and receptor function by analyzing content, related gene expression, phenotypes after RNAi these genes. Moreover, performed treatment exposure to determine potential pharmacological against toxicity. After exposure, content was reduced 0.1–10 μg/L 6-PPDQ, which due decreased expression W07E1.1, glna-1/2/3, alh-6 governing from α-ketoglutarate, glutamine, proline. 6-PPDQ-exposed nematodes, caused susceptibility Among transporter genes, glt-1 6-PPDQ. genes (glr-1, glr-2, glr-4), their alh-6, glt-1. resulted toxicity, daf-7, jnk-1, dbl-1 were identified as targets neuronal glr-1, glr-4. Furthermore, 5 mM suppressed toxicity increased Our results demonstrated risk disrupting affecting receptors, induction.

Язык: Английский

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6-PPD quinone at environmentally relevant concentrations disrupts citric acid cycle in Caenorhabditis elegans: Role of reduction in acetyl CoA and pyruvate contents

Environmental Chemistry and Ecotoxicology, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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6-PPD quinone induces response of nuclear hormone receptors in the germline associated with formation of reproductive toxicity in Caenorhabditis elegans

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138815 - 138815

Опубликована: Июнь 1, 2025

Язык: Английский

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