Persistence against benzalkonium chloride promotes rapid evolution of tolerance during periodic disinfection

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Ноя. 23, 2021

Abstract Biocides used as disinfectants are important to prevent the transmission of pathogens, especially during current antibiotic resistance crisis. This crisis is exacerbated by phenotypically tolerant persister subpopulations that can survive transient treatment and facilitate evolution. Here, we show E. coli displays persistence against a widely disinfectant, benzalkonium chloride (BAC). Periodic, persister-mediated failure disinfection rapidly selects for BAC tolerance, which associated with reduced cell surface charge mutations in lpxM locus, encoding an enzyme lipid A biosynthesis. Moreover, fitness cost incurred tolerance turns into benefit presence antibiotics, suggesting selective advantage BAC-tolerant mutants environments. Our findings highlight links between evolution antimicrobials.

Язык: Английский

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Classical and alternative disinfection strategies to control the COVID-19 virus in healthcare facilities: a review

Environmental Chemistry Letters, Год журнала: 2021, Номер 19(3), С. 1945 - 1951

Опубликована: Янв. 22, 2021

Язык: Английский

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Protective Face Mask Filter Capable of Inactivating SARS-CoV-2, and Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis

Polymers, Год журнала: 2021, Номер 13(2), С. 207 - 207

Опубликована: Янв. 8, 2021

Face masks have globally been accepted to be an effective protective tool prevent bacterial and viral transmission, especially against indoor aerosol transmission. However, commercial face contain filters that are made of materials not capable inactivating either SARS-CoV-2 or multidrug-resistant bacteria. Therefore, symptomatic asymptomatic individuals can infect other people even if they wear them because some viable loads escape from the masks. Furthermore, contact transmission occur after touching mask, which constitutes increasing source contaminated biological waste. Additionally, pathogens contribute SARS-CoV-2-mediated pneumonia disease complex, their resistance antibiotics in treatment is at alarming rate. In this regard, herein, we report development a non-woven mask filter fabricated with biofunctional coating benzalkonium chloride more than 99% particles one minute contact, life-threatening methicillin-resistant Staphylococcus aureus epidermidis (normalized antibacterial halos 0.52 ± 0.04 0.72 0.04, respectively). Nonetheless, despite results obtained, further studies needed ensure safety correct use technology for mass production commercialization broad-spectrum antimicrobial filter. Our novel would useful many healthcare workers researchers working urgent challenging field.

Язык: Английский

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Biocidal Resistance in Clinically Relevant Microbial Species: A Major Public Health Risk

Pathogens, Год журнала: 2021, Номер 10(5), С. 598 - 598

Опубликована: Май 14, 2021

Antimicrobial resistance is one of the greatest dangers to public health 21st century, threatening treatment and prevention infectious diseases globally. Disinfection, elimination microbial species via application biocidal chemicals, essential control safeguard animal human health. In an era antimicrobial emerging disease, effective measures vital protect The COVID-19 pandemic example increasing demand for solutions reduce eliminate disease transmission. However, there recognition into relationship between biocide use proliferation Resistance species, particularly multidrug-resistant pathogens. One Health approach WHO action plan combat AMR require active surveillance monitoring species; however, often overlooked. ESKAPE (

Язык: Английский

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Surfactants – Compounds for inactivation of SARS-CoV-2 and other enveloped viruses

Current Opinion in Colloid & Interface Science, Год журнала: 2021, Номер 55, С. 101479 - 101479

Опубликована: Июнь 12, 2021

Язык: Английский

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