Basic science review of transcutaneous osseointegration: current status, research gaps and needs, and defining future directions DOI Creative Commons
Bailey V. Fearing, Ida Leah Gitajn, Sarah M. Romereim

и другие.

OTA International The Open Access Journal of Orthopaedic Trauma, Год журнала: 2025, Номер 8(1S)

Опубликована: Март 1, 2025

Basic science research is vital for advancing the emerging field of bone-anchored limb replacement (BALR), or osseointegration (OI). This article discusses clinical challenges BALR/OI, summarizes current basic regarding those challenges, identifies gaps, and proposes future directions. OI draws from related fields such as orthopaedic implants dentistry. There a need small animal models to study critical questions osseointegration, including implant-associated infections. Small are also ensuring safety efficacy novel treatments in this vulnerable population. Key issues include infection prevention through implant surface modifications, biofilm-targeting technologies, antimicrobial advancements. The skin-implant portal, unique BALR, poses significant challenges. Research on skin attachment inflammatory processes crucial. Noninfectious loosening implants, though infrequent, needs further investigation. review emphasizes collaborative efforts develop effective preclinical innovative strategies. Addressing these essential optimizing patient outcomes field.

Язык: Английский

Magnesium alloy with superhydrophilic magnesium/gallium-layered double hydroxides coating with antibacterial property as implant material DOI
Jingjing Liu,

Fengjun Shi,

Sisi Ma

и другие.

Journal of Nanoparticle Research, Год журнала: 2025, Номер 27(1)

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Basic science review of transcutaneous osseointegration: current status, research gaps and needs, and defining future directions DOI Creative Commons
Bailey V. Fearing, Ida Leah Gitajn, Sarah M. Romereim

и другие.

OTA International The Open Access Journal of Orthopaedic Trauma, Год журнала: 2025, Номер 8(1S)

Опубликована: Март 1, 2025

Basic science research is vital for advancing the emerging field of bone-anchored limb replacement (BALR), or osseointegration (OI). This article discusses clinical challenges BALR/OI, summarizes current basic regarding those challenges, identifies gaps, and proposes future directions. OI draws from related fields such as orthopaedic implants dentistry. There a need small animal models to study critical questions osseointegration, including implant-associated infections. Small are also ensuring safety efficacy novel treatments in this vulnerable population. Key issues include infection prevention through implant surface modifications, biofilm-targeting technologies, antimicrobial advancements. The skin-implant portal, unique BALR, poses significant challenges. Research on skin attachment inflammatory processes crucial. Noninfectious loosening implants, though infrequent, needs further investigation. review emphasizes collaborative efforts develop effective preclinical innovative strategies. Addressing these essential optimizing patient outcomes field.

Язык: Английский

Процитировано

0