Polysaccharide from Ganoderma lucidum ameliorates cognitive impairment by regulating the inflammation of the brain–liver axis in rats

Food & Function, Год журнала: 2021, Номер 12(15), С. 6900 - 6914

Опубликована: Янв. 1, 2021

Ganoderma lucidum (G. lucidum) polysaccharide-1 (GLP-1) is one of the polysaccharides isolated from fruiting bodies G. lucidum. Inflammation in brain-liver axis plays a vital role progress cognitive impairment. In this study, beneficial effect GLP-1 on d-galactose (d-gal) rats was carried out by regulating inflammation axis. A Morris water maze test used to assess ability d-gal rats. ELISA and/or western blot analysis were detect blood ammonia and inflammatory cytokines levels Metabolomic evaluate changes small molecule metabolomics between brain liver. As result, could obviously ameliorate impairment The mechanism related decreasing TNF-α, IL-6, phospho-p38MAPK, phospho-p53, phospho-JNK1 + JNK2 JNK3, increasing IL-10 TGF-β1, regulation metabolic disorders Our study suggests that be exploited as an effective food or health care product prevent delay improve quality life.

Язык: Английский

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Gut microbial metabolite urolithin B attenuates intestinal immunity functionin vivoin aging mice andin vitroin HT29 cells by regulating oxidative stress and inflammatory signalling

Food & Function, Год журнала: 2021, Номер 12(23), С. 11938 - 11955

Опубликована: Янв. 1, 2021

Urolithin B (Uro B), one of the major subcategories urolithins (microbial metabolites) found in various tissues after ellagitannin consumption, has been demonstrated to possess antioxidant and anti-inflammatory effects. The current research mainly focused on ameliorative effect Uro intestinal immunity function exploring potential mechanisms its protective role aging mice induced by D-galactose (D-gal). In research, we assessed effects inflammatory injury lipopolysaccharides HT29 cells. D-gal-induced accelerated model vivo that could elevate activities superoxide dismutase, catalase, glutathione peroxidase, total anti-oxidation capability, decrease malondialdehyde content, regulate levels cytokines (IL-6, TNF-α, IFN-γ, IL-4, IL-1β) small intestine, reshape composition gut microbiota barrier mice. Furthermore, inhibited expression TLR4, IRAK4, TRAF6, IKK-β, NF-κB p65, HMGB1 intestine. Therefore, these findings indicated effectively weakened intestine ameliorated through downregulation HMGB1-TLR4-NF-κB pathway be considered a healthcare product prevent diseases associated with an immune system.

Язык: Английский

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Polysaccharides from steam‐processed Polygonatum cyrtonema Hua protect against d‐galactose‐induced oxidative damage in mice by activation of Nrf2/HO‐1 signaling

Journal of the Science of Food and Agriculture, Год журнала: 2022, Номер 103(2), С. 779 - 791

Опубликована: Авг. 26, 2022

Polygonatum cyrtonema Hua is cultivated for its edible and medical value. The steam-processed rhizome of P. the main form daily consumption it has been used traditionally in tonics treating various age-related disorders. aim our study was to compare physicochemical properties antioxidant activity polysaccharides respectively extracted from crude Cyrtonema (PCPC), (PCPS), explore a possible underlying mechanism.The PCPC with molecular weight 4.35 × 103 Da mainly consisted fructose trace amounts glucose, whereas PCPS 4.24 104 composed fructose, arabinose, xylose, mannose, galacturonic acid glucuronic acid. had triple-helical conformation random coil. Both exhibited free radicals- scavenging vitro. In mouse model oxidative damage, or treatment significantly reversed histopathological alterations, reactive oxygen species (ROS) accumulation reduction enzyme activity. They both also promoted Nrf2 nuclear transport by decreasing Keap-1 expression increasing HO-1 expression. vitro vivo, more potent than PCPC.Overall, results suggest that stronger effect on prevention damage activating Nrf2/HO-1 signaling. This demonstrates role provides valuable perspective as functional agent. © 2022 Society Chemical Industry.

Язык: Английский

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Metallothionein-3-mediated intracellular zinc mediates antioxidant and anti-inflammatory responses in the complete Freund’s adjuvant-induced inflammatory pain mouse model

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Фев. 4, 2025

Язык: Английский

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Rice peptide and collagen peptide prevented potassium oxonate-induced hyperuricemia and renal damage

Food Bioscience, Год журнала: 2021, Номер 42, С. 101147 - 101147

Опубликована: Май 30, 2021

Язык: Английский

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The rice bran peptide KF-8 extends the lifespan and improves the healthspan of Caenorhabditis elegans via skn-1 and daf-16

Food & Function, Год журнала: 2022, Номер 13(5), С. 2427 - 2440

Опубликована: Янв. 1, 2022

With the increased aging of population, extension lifespan and improvement healthspan have become important. Our previous studies showed that rice bran peptide KF-8 exerts an antioxidant effect in cells mice. In this study, we evaluated effects on Caenorhabditis elegans. We found prolonged life nematodes no reproductive toxicity towards nematodes. addition, improved motility resulted extended body length. Using hydrogen peroxide juglone as stress inducers, anti-stress ability upregulated expressions skn-1, daf-16 genes. life-prolonging was lost skn-1 mutant strains strains, indicating may exert anti-aging through daf-16.

Язык: Английский

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Exogenous Bioactive Peptides Have a Potential Therapeutic Role in Delaying Aging in Rodent Models

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(3), С. 1421 - 1421

Опубликована: Янв. 26, 2022

In recent years, some exogenous bioactive peptides have been shown to promising anti-aging effects. These may a mechanism similar endogenous peptides, and can even regulate the release of active play synergistic role with peptides. Most aging studies use rodents that are easy maintain in laboratory relatively homogenous genotypes. Moreover, many using rodent models only focus on activity single or while regulatory effects remain largely under-investigated. Furthermore, these individual organs systems. However, pathological changes one organ usually lead multi-organ complications. Some could be used for rescuing damage associated aging. this paper, we review reports summarize action as well discuss regulation

Язык: Английский

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Resveratrol, a novel inhibitor of GLUT9, ameliorates liver and kidney injuries in a d-galactose-induced ageing mouse model via the regulation of uric acid metabolism

Food & Function, Год журнала: 2021, Номер 12(18), С. 8274 - 8287

Опубликована: Янв. 1, 2021

Accumulating evidence has shown that chronic injection of D-galactose (D-gal) can mimic natural ageing and induce liver kidney injury. Previous studies showed D-gal increased uric acid (UA) levels in mice. The increase UA caused inflammation, accelerated oxidative stress, aggravated Oxidative stress inflammation play vital roles the process. Therefore, reducing mice improved Glucose transporter 9 (GLUT9) is responsible for reabsorption body, its inhibition helps downregulate levels. present study investigated UA-lowering activity GLUT9 inhibitor resveratrol (RSV) using patch clamping technique established our laboratory vitro. This research first to demonstrate RSV effectively inhibits uptake via (IC50 = 68.77 μM) An vivo was also performed investigate possible protective effect on D-gal-induced significantly reduced serum downregulation mRNA protein expression promoted excretion excess through urine. Biochemical analysis downregulated abnormal increases alanine aminotransferase (ALT), aspartate (AST), blood urea nitrogen (BUN) creatinine (CRE) by long-term treatment, which pathological damage, superoxide dismutase (SOD) decreased content malondialdehyde (MDA) kidneys. inflammatory cytokines, interleukin IL-6, IL-1β tumor necrosis factor (TNF)-α kidneys Our findings provide new insights into treatment strategies ageing-induced injury reveal a mechanism RSV-induced reduction individuals.

Язык: Английский

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Antarctic krill peptides improve scopolamine-induced memory impairment in mice

Food Bioscience, Год журнала: 2022, Номер 49, С. 101987 - 101987

Опубликована: Авг. 23, 2022

Язык: Английский

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Novel antioxidant peptide from broken rice resist H2O2-induced premature senescence in 2BS cells via PI3K/Akt and JNK/Bax signaling pathway

Food Bioscience, Год журнала: 2023, Номер 52, С. 102376 - 102376

Опубликована: Янв. 13, 2023

Язык: Английский

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