Anti-inflammation Mechanisms of Flavones Are Highly Sensitive to the Position Isomers of Flavonoids: Acacetin vs Biochanin A

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

Acacetin (ACA) and biochanin A (BCA) are isomeric monomethoxyflavones with different structural positions of the 4'-methoxy-phenyl group. Both them present in many commonly consumed foods, such as citrus fruits vegetables, have been discovered anti-inflammatory activities, but their mechanisms action not clearly elucidated at molecular level. Herein, we reported structure-activity relationship ACA BCA regarding potency inhibiting nitric oxide (NO) production, proinflammatory enzyme expression, mRNA expression cytokines lipopolysaccharide (LPS)-induced RAW 264.7 cells. Furthermore, transcriptome analysis was conducted to map out overall pathways impacted by these two isomers. Our results showed that possessed higher suppressive activity production (IC

Язык: Английский

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Photocatalytic acceptorless dehydrogenation of flavanones by cationic Eosin Y as a bifunctional catalyst

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

We report the first example of photocatalytic acceptorless dehydrogenation using cationic Eosin Y as a bifunctional photocatalyst, without metal catalysts or HAT reagents.

Язык: Английский

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Methyl Derivatives of Flavone as Potential Anti-Inflammatory Compounds

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 729 - 729

Опубликована: Янв. 16, 2025

Flavones are natural compounds that broadly distributed in our diet. Their unique properties provide the possibility to control immune system and process of inflammation. A high intake flavonoids, including flavones, may offer protection against reactive oxygen species, inflammation, chronic diseases. In this research, we evaluated anti-inflammatory effect five methylflavones, 2′-methylflavone (5C), 3′-methylflavone (6C), 4′-methylflavone (7C), 6-methylflavone (8C), 6-methyl-8-nitroflavone (12C), lipopolysaccharide (LPS) stimulated RAW 264.7 cells (murine macrophage cell line). We estimated nitrite concentration detected species using chemiluminescence method. Moreover, measured production pro-inflammatory cytokines Bio-Plex Magnetic Luminex Assay. As a result findings, have established some methyl derivatives flavone inhibit nitric oxide (NO) generated by LPS-stimulated macrophages, but they also an influence on production. This study showed (5C) (6C) possess strongest activity among all tested flavone. conclusion, demonstrated methylflavones be potentially valuable for alleviation inflammatory reactions.

Язык: Английский

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Mechanistic Insights into the Anticancer Potential of Methoxyflavones Analogs: A Review

Molecules, Год журнала: 2025, Номер 30(2), С. 346 - 346

Опубликована: Янв. 16, 2025

2-phenylchromen-4-one, commonly known as flavone, plays multifaceted roles in biological response that can be abundantly present natural sources. The methoxy group naturally occurring flavones promotes cytotoxic activity various cancer cell lines by targeting protein markers, facilitating ligand-protein binding mechanisms and activating cascading downstream signaling pathways leading to death. However, the lipophilic nature of these analogs is a key concern it impacts drug membrane transfer. While lipophilicity crucial for efficacy, excessive effects flavonoids reduce water solubility hinder transport target sites. Recent vitro studies suggest incorporation polar hydroxyl groups which form hydrogen bonds stabilize free radicals may help overcome challenges associated with while maintaining their essential properties. Naturally coexisting methoxyflavones, this review explores synergistic role hydroxy moieties through bonding capacity maximizing cytotoxicity against lines. physicochemical analysis revealed potential intramolecular interaction favorable electron delocalization region between both improve levels. Together, provides useful strategy structure-activity relationship (SAR) flavonoid distinct suggesting optimal functional positioning achieve balanced lipophilicity, effective bonding, simultaneously minimized steric hindrance specific types.

Язык: Английский

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Research progress of flavonoids targeting estrogen receptor in the treatment of breast cancer

Bioorganic & Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 118106 - 118106

Опубликована: Фев. 1, 2025

Язык: Английский

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