Plant Nano Biology,
Год журнала:
2022,
Номер
3, С. 100022 - 100022
Опубликована: Дек. 16, 2022
Exosomes
are
nanovesicles
in
the
size
range
of
30–150
nm,
produced
by
mammalian
and
plant
cells.
They
have
lipid
bilayer
enclosing
a
unique
mix
biologically
active
components
including
proteins,
nucleic
acids,
metabolites
lipids,
that
depend
on
their
source
origin.
The
derived
gaining
considerable
research
attention
due
to
ability
be
absorbed
from
dietary
sources.
Their
bioactive
impart
many
therapeutic
properties
them
such
as
anti-tumorigenic,
anti-oxidative,
anti-inflammatory,
hepatoprotective
effects
tissue
regeneration.
possibilities
using
exosomes
for
drug
delivery
is
also
promising.
This
review
focusses
biogenesis
biological
nature
plants
describes
various
inherent
properties.
It
sheds
light
recently
developed
methods
study
them.
existing
challenges
exosomal
well
future
prospective
highlighted.
Overall,
it
an
update
advancements
which
can
provide
replacement
toxic
synthetic
drugs
disease
therapy.
Abstract
Extracellular
vesicles
(EVs)
are
nano‐sized
surrounded
by
a
lipid
bilayer
containing
bioactive
materials,
including
proteins,
nucleic
acids,
lipids,
and
metabolites.
They
function
as
messengers
secreted
cells,
playing
crucial
role
in
cell‐to‐cell
communication.
Plant‐derived
extracellular
(P‐EVs),
plant
being
investigated
therapeutic
agents
drug
delivery
carriers
due
to
their
high
biocompatibility,
productivity,
effective
cellular
delivery,
exerting
effects
through
physiological
pathways.
However,
methods
for
EV
production
directly
from
plants
P‐EV
identification
components
have
not
yet
been
established.
A
comprehensive
understanding
of
the
potential
biodistribution
P‐EVs
is
essential
application
systemic
therapeutics
carriers.
This
review
covers
recent
separating
explores
identification.
It
also
summarizes
intrinsic
applications
engineered
P‐EVs.
Finally,
it
provides
tailored
strategies
examining
according
route
administration
analyzing
application.
Given
diversity
distinctiveness
plants,
development
using
shows
great
promise
anticipated
create
new
paradigm
therapeutics.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 14, 2025
There
are
abundant
natural
products
resources
and
extensive
clinical
use
experience
in
China.
However,
the
active
components
of
generally
have
problems
such
as
poor
water
solubility
low
bioavailability,
which
limit
their
druggability.
Carrier-free
nanoparticles,
nanocrystals,
self-assembled
extracellular
vesicles
derived
from
both
animal
plant
sources,
great
application
potential
improving
safety
efficacy
drugs
due
to
simple
flexible
preparation
methods,
high
drug
loading
capacity
delivery
efficiency,
well
long
half-life
blood
circulation.
It
has
been
widely
used
biomedical
fields
anti-tumor,
anti-bacterial,
anti-inflammatory
anti-oxidation.
Therefore,
based
on
that
clinic,
this
review
focuses
advantages
carrier-free
nanoparticles
delivering
compounds,
order
improve
process
vivo
draggability.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2025,
Номер
unknown, С. 1 - 21
Опубликована: Март 19, 2025
Exosomes
are
nanoscale
particles
with
a
lipid
bilayer
membrane
that
were
first
identified
in
mammalian
cells.
Plant-derived
exosome-like
nanoparticles
(PELNs)
share
structural
and
molecular
similarities
exosomes,
including
lipids,
proteins,
microRNA
(miRNA),
plant-derived
metabolites.
Owing
to
their
unique
characteristics,
such
as
outstanding
stability,
low
immunogenicity,
high
biocompatibility,
sustainability,
PELNs
have
emerged
promising
natural
bioactive
agents
the
capacity
for
cross-kingdom
cellular
regulation.
Dietary
supplementation
PELNs,
particularly
from
fruits
vegetables,
has
demonstrated
health
benefits.
An
increasing
number
of
studies
indicated
beneficial
effects
on
colon
health.
This
review
summarizes
isolation
characterization
uptake,
distribution
after
oral
ingestion.
Furthermore,
this
emphasizes
interactions
between
gut
microbiota,
immune
system,
uptake
by
modulation
bacteria
metabolism,
responses
PELNs.
Additionally,
applications
components
drug
carriers
targeting
reviewed.
In
summary,
represent
versatile
approach
improve
health,
potential
both
therapeutic
preventive
healthcare
strategies.
Plant Nano Biology,
Год журнала:
2022,
Номер
3, С. 100022 - 100022
Опубликована: Дек. 16, 2022
Exosomes
are
nanovesicles
in
the
size
range
of
30–150
nm,
produced
by
mammalian
and
plant
cells.
They
have
lipid
bilayer
enclosing
a
unique
mix
biologically
active
components
including
proteins,
nucleic
acids,
metabolites
lipids,
that
depend
on
their
source
origin.
The
derived
gaining
considerable
research
attention
due
to
ability
be
absorbed
from
dietary
sources.
Their
bioactive
impart
many
therapeutic
properties
them
such
as
anti-tumorigenic,
anti-oxidative,
anti-inflammatory,
hepatoprotective
effects
tissue
regeneration.
possibilities
using
exosomes
for
drug
delivery
is
also
promising.
This
review
focusses
biogenesis
biological
nature
plants
describes
various
inherent
properties.
It
sheds
light
recently
developed
methods
study
them.
existing
challenges
exosomal
well
future
prospective
highlighted.
Overall,
it
an
update
advancements
which
can
provide
replacement
toxic
synthetic
drugs
disease
therapy.
