Recent Advances of Coumarin-Type Compounds in Discovery of Pesticides

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Coumarin, a naturally occurring active ingredient with various biological activities in pesticides, is commonly found plants belonging to the Rutaceae and Apiaceae families. Thanks its unique structural properties natural benefits, coumarin derivatives exhibit wide range of physiological activities, including insecticidal, antifungal, antibacterial, herbicidal, antiviral properties. These compounds have attracted considerable interest field pesticide development, although there lack comprehensive reviews on their use pesticides. This Review aims provide detailed overview applications covering structure–activity relationship analyses, mechanisms action. It hoped that this will offer new insights into discovery these development.

Язык: Английский

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Trifluoromethylpyridine piperazine derivatives: synthesis and anti‐plant virus activity

Pest Management Science, Год журнала: 2023, Номер 79(7), С. 2571 - 2580

Опубликована: Март 3, 2023

The cucumber mosaic virus (CMV) is well-known for its expansive host range and distribution, resulting in a detrimental effect on agricultural production, thus making it imperative to implement measures control.Novel compounds S1-S28 were synthesized by connecting trifluoromethyl pyridine, amide piperazine scaffolds. Bioassays indicated that most of the exhibited good curative effects against CMV, with half maximal effective concentration (EC50 ) values S1, S2, S7, S8, S10, S11, S15, S28 being 119.6, 168.9, 197.6, 169.1, 97.9, 73.9, 224.4, 125.2 μg mL-1 , respectively, which lower than EC50 ningnanmycin (314.7 ). Compounds S5 S8 protective activities 170.8 95.0 at 171.4 . inactivation S6 500 remarkably high 66.1% 78.3%, surpassing (63.5%). Additionally, their more favorable 22.2 18.1 (38.4 And molecular docking dynamics simulation showed compound had better binding CMV-coat protein, providing possible explanation anti-CMV activity S8.Compound strong affinity protein impacted self-assemble CMV particles. Compound could be potential lead discovering new anti-plant candidate. © 2023 Society Chemical Industry.

Язык: Английский

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Anti-TMV Activity and Functional Mechanisms of Two Diterpenoid Alkaloids Isolated from Dendrobium findlayanum

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Tobacco mosaic virus (TMV) is a major threat to crops, making the discovery of green biopesticides essential. Herein, we present two active ingredients derived from medicinal plant Dendrobium findlayanum, findlayine A (1) and dendrofindline B (2), as promising precursor compounds for TMV inhibitors. Among them, 2 inhibited infestation on tobacco leaves at rate 38.6%, which was close that commercial antiviral agent ningnanmycin (43.1%). Both 1 could effectively alleviate destruction leaf protoplasts by infestation, enhance resistance affecting activities phenylalaninammo-nialyase (PAL), peroxidase (POD) superoxide dismutase (SOD). Additionally, significantly down-regulated expression coat protein (CP) CP-mediated aggregation TMV, thereby reducing its capacity. This study systematically investigated mechanism anti-TMV activity diterpenoid alkaloids D. with view providing new insights into creation novel agents.

Язык: Английский

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Coumarin derivatives containing the 1,3,4 oxadiazole/thiadiazole moiety discovered as potential anti-tobacco mosaic virus agents

Molecular Diversity, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Язык: Английский

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Reprogrammed Plant Metabolism During Viral Infections: Mechanisms, Pathways and Implications

Molecular Plant Pathology, Год журнала: 2025, Номер 26(2)

Опубликована: Фев. 1, 2025

ABSTRACT Plant viruses pose a significant threat to global agriculture, leading substantial crop losses that jeopardise food security and disrupt ecosystem stability. These viral infections often reprogramme plant metabolism, compromising key pathways critical for growth defence. For instance, by cucumber mosaic virus alter amino acid secondary metabolite biosynthesis, including flavonoid phenylpropanoid pathways, thereby weakening defences. Similarly, tomato bushy stunt disrupts lipid metabolism altering the synthesis accumulation of sterols phospholipids, which are essential replication compromise membrane integrity. Recent advancements in gene‐editing technologies, such as CRISPR/Cas9, metabolomics offer innovative strategies mitigate these impacts. Precise genetic modifications can restore or optimise disrupted metabolic enhancing resilience infections. Metabolomics further aids identifying biomarkers linked resistance, guiding breeding programmes aimed at developing virus‐resistant plants. By reducing susceptibility crops infections, approaches hold potential reduce dependence on chemical pesticides, increase yields promote sustainable agricultural practices. Future research should focus expanding our understanding virus–host interactions molecular level while exploring long‐term ecological impacts Interdisciplinary integrating multi‐omics technologies management will be addressing challenges posed ensuring

Язык: Английский

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Coumarin derivatives as inhibitors against monoamine oxidase: structure-activity relationships and inhibitory mechanisms

Acta Materia Medica, Год журнала: 2025, Номер 4(2)

Опубликована: Янв. 1, 2025

Monoamine oxidase (MAO) is a useful target in the treatment of neurodegenerative diseases and depressive disorders. Understanding structure-activity relationship (SAR) mechanisms underlying MAO inhibitors crucial but challenging. The coumarin scaffold has been shown to be ideal for inhibitors, yet SAR inhibition selectivity based on remains unclear. In this study fluorescence-based high throughput screening method was developed using fluorescent substrate (MR2). Subsequently, three series derivatives, including esculetin, daphnetin 3-substituted coumarin, were synthesized inhibitory effects assayed. revealed that phenyl substitution had unique effect activity selectivity. Specifically, 3-phenyl derivatives significantly enhanced MAO-B increased MAO-A, while 4-phenyl more effective MAO-A inhibition. Discovery studios also utilized investigate structural requirements by coumarins. Furthermore, five elucidated through enzymatic kinetics analysis molecular docking simulations. These findings provide new insights into interactions between coumarins MAOs contribute development coumarin-based inhibitors.

Язык: Английский

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Frontier Exploration of Synthesis and Biological Activity of Vanillin Derivatives

Journal of Organic Chemistry Research, Год журнала: 2025, Номер 13(01), С. 13 - 20

Опубликована: Янв. 1, 2025

Язык: Английский

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Design, Synthesis, Biological Evaluation, and In Silico Study of Aspirin–Sulfonamide Hybrids as Potential Anticancer Agents

Archiv der Pharmazie, Год журнала: 2025, Номер 358(5)

Опубликована: Май 1, 2025

ABSTRACT Aspirin's potential as a cancer treatment had garnered significant attention over the past 50 years. Presently, researchers are focused on structurally modifying aspirin to enhance its anticancer efficacy. In this study, was employed parent compound, and N‐acylation of chloride with piperazine‐sulfonamide hybrids utilized efficiently synthesize promising agents 3 . Biological assays structure–activity relationship analysis demonstrated that incorporation thiophene groups significantly enhanced activity aspirin. Among all eight human cells treated, hybrid 3k , containing bromothiophene structure, most effective against non‐small‐cell lung (A549) (IC = 36 μM), exhibiting 33‐fold greater toxicity than > 1200 μM) higher selectivity index (SI 6). Mechanistic studies revealed induced apoptosis in A549 arrested cell cycle at G0/G1 phase. Molecular docking COX‐2 inhibition assay indicated likely exerts effects through protein. These findings underscore novel therapeutic agent for contribution expanding antitumor scope

Язык: Английский

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Discovery of novel 3-phenylhydrazone coumarin derivatives as potential antifungal agents against phytopathogenic fungi

Food Chemistry, Год журнала: 2025, Номер 486, С. 144655 - 144655

Опубликована: Май 10, 2025

Язык: Английский

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Development of dual-function disulfaneyl oxadiazole bactericides by structurally incorporating β-carboline moieties

Bioorganic Chemistry, Год журнала: 2025, Номер 162, С. 108606 - 108606

Опубликована: Май 17, 2025

Язык: Английский

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