Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 14, 2022
Dyslipidemias
are
disorders
of
plasma
levels
lipids,
such
as
elevated
total
cholesterol
and
triglyceride,
that
associated
with
various
human
diseases
including
cardiovascular
disease
(CVD)
non-alcoholic
fatty
liver
(NAFLD).
Statins
the
first-line
drugs
for
treatment
dyslipidemia.
However,
a
substantial
proportion
patients
cannot
reach
recommended
LDL-c
level
even
highest
tolerated
doses
statins,
there
is
no
available
drug
specifically
NAFLD
therapy.
Sea
cucumbers
one
widely
distributed
invertebrates,
an
important
resource
food
medicine.
have
many
valuable
nutrients
saponins,
acids,
phospholipids,
cerebrosides,
sulfated
polysaccharides,
well
proteins
peptides.
In
recent
years,
these
natural
products
derived
from
sea
attracted
attentions
CVD
because
their
lipid-lowering
effect
low
toxicity.
hypolipidemic
mechanisms
action
structure-activity
relationship
bioactive
components
not
been
well-documented
in
literature.
This
review
article
summarizes
signaling
pathways
potential
cucumber-derived
compounds
carbohydrates
peptides
proteins.
will
provide
information
useful
development
investigation
other
resources.
Antioxidants,
Год журнала:
2023,
Номер
12(4), С. 788 - 788
Опубликована: Март 23, 2023
In
recent
years,
numerous
reports
have
described
bioactive
peptides
(biopeptides)/hydrolysates
produced
from
various
food
sources.
Biopeptides
are
considered
interesting
for
industrial
application
since
they
show
functional
properties
(e.g.,
anti-aging,
antioxidant,
anti-inflammatory,
and
antimicrobial
properties)
technological
solubility,
emulsifying,
foaming).
Moreover,
fewer
side
effects
than
synthetic
drugs.
Nevertheless,
some
challenges
must
be
overcome
before
their
administration
via
the
oral
route.
The
gastric,
pancreatic,
small
intestinal
enzymes
acidic
stomach
conditions
can
affect
bioavailability
levels
that
reach
site
of
action.
Some
delivery
systems
been
studied
to
avoid
these
problems
microemulsions,
liposomes,
solid
lipid
particles).
This
paper
summarizes
results
studies
conducted
on
biopeptides
isolated
plants,
marine
organisms,
animals,
biowaste
by-products,
discusses
potential
in
nutricosmetic
industry,
considers
could
maintain
bioactivity.
Our
environmentally
sustainable
products
used
as
antimicrobial,
anti-inflammatory
agents
formulations.
Biopeptide
production
requires
expertise
analytical
procedures
good
manufacturing
practice.
It
is
hoped
new
developed
simplify
large-scale
authorities
adopt
regulate
use
appropriate
testing
standards
guarantee
population’s
safety.
Foods,
Год журнала:
2024,
Номер
13(6), С. 885 - 885
Опубликована: Март 14, 2024
Food-derived
peptides
have
been
extensively
studied
for
their
benefits
in
humans.
Hen
eggs,
characterized
by
high
protein
and
digestibility,
are
an
excellent
source
of
food-derived
bioactive
peptides.
This
review
summarizes
the
preparation
methods,
purification,
identification
hen
egg-derived
(HEPs).
The
methods
mainly
include
enzymatic
hydrolysis,
microbial
fermentation,
chemical
synthesis.
Genetic
engineering
is
emerging
trend
HEP
preparation.
Then,
we
summarize
biological
activities
HEPs,
such
as
antioxidant
activities,
enzyme
inhibitory
activity,
antibacterial
which
activity
comprehensively
summarized
first
time.
structure–activity
relationship
underlying
mechanism
HEPs
further
elucidated.
Finally,
applications,
future
challenges,
opportunities
were
discussed
food
non-food
sectors.
We
focus
on
potential
applications
intestinal
health
assembly
delivery
provide
a
reference
utilization
commercial
development
HEPs.
Nutrients,
Год журнала:
2023,
Номер
15(22), С. 4813 - 4813
Опубликована: Ноя. 17, 2023
The
incidence
of
ulcerative
colitis
(UC)
is
increasing
annually.
There
are
few
treatments
for
UC
patients,
and
some
drugs
have
serious
side
effects.
Sea
cucumber
peptide
(SCP)
has
anti-inflammatory,
antioxidant
other
biological
activities,
various
sea
species
in
pharmaceutical
development.
However,
relevant
studies
on
the
effects
SCP
progression
still
lacking.
In
this
study,
a
mouse
model
acute
was
induced
by
3%
dextran
sulfate
(DSS),
effect
500
mg/kg
investigated.
results
showed
that
can
alleviate
DSS-induced
colon
damage
intestinal
barrier
damage.
significantly
inhibited
expression
inflammatory
factors
oxidative
stress
mice.
reversed
microbiota
dysregulation
DSS,
growth
Sutterella,
Prevotella_9
Escherichia-Shigella
harmful
bacteria,
increased
abundance
Lachnospiraceae_NK4A136_group.
At
same
time,
treatment
LPS-induced
polarization
M1
macrophages,
which
may
be
mediated
two
monopeptides,
IPGAPGVP
TGPIGPPGSP,
via
FPR2.
conclusion,
protect
against
modulating
composition
inhibiting
macrophages.
Marine Drugs,
Год журнала:
2022,
Номер
20(11), С. 693 - 693
Опубликована: Ноя. 3, 2022
Chronic
inflammation
can
extensively
burden
a
healthcare
system.
Several
synthetic
anti-inflammatory
drugs
are
currently
available
in
clinical
practice,
but
each
has
its
own
side
effect
profile.
The
planet
is
gifted
with
vast
and
diverse
oceans,
which
provide
treasure
of
bioactive
compounds,
the
chemical
structures
may
valuable
pharmaceutical
agents.
Marine
organisms
contain
variety
some
have
activity
received
considerable
attention
from
scientific
community
for
development
drugs.
This
review
describes
such
as
well
crude
extracts
(published
during
2010–2022)
echinoderms:
namely,
sea
cucumbers,
urchins,
starfish.
Moreover,
we
also
include
their
structures,
evaluation
models,
activities,
including
molecular
mechanism(s)
these
compounds.
paper
highlights
potential
applications
those
marine-derived
compounds
industry
to
develop
leads
pipeline.
In
conclusion,
this
serve
well-documented
reference
research
progress
on
echinoderms
against
various
chronic
inflammatory
conditions.
Archiv der Pharmazie,
Год журнала:
2023,
Номер
357(1)
Опубликована: Окт. 18, 2023
Abstract
Apostichopus
japonicus
,
also
known
as
Stichopus
with
medicinal
and
food
homologous
figures,
is
a
globally
recognized
precious
ingredient
extremely
high
nutritional
value.
There
no
relevant
review
available
through
literature
search,
so
this
article
selects
the
research
articles
keywords
“sea
cucumber”
“
(
)”
in
six
professional
databases,
such
Wiley,
PubMed,
ScienceDirect,
ACS,
Springer,
Web
of
Science,
from
2000
to
present,
summarizing
extraction,
isolation,
purification
methods
for
four
major
categories
(polysaccharides,
proteins
peptides,
saponins,
other
components)
A.
chemical
substances
10
effective
biological
activities
.
Included
are
anticoagulation,
anticancer/antitumor
activities,
hematopoiesis,
regulation
gut
microbiota,
immune
regulatory
that
correspond
traditional
efficacy.
Literature
support
provided
development
medicines
functional
foods
related
aspects
play
leading
role
future
directions.
