Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 14, 2022
Dyslipidemias
are
disorders
of
plasma
levels
lipids,
such
as
elevated
total
cholesterol
and
triglyceride,
that
associated
with
various
human
diseases
including
cardiovascular
disease
(CVD)
non-alcoholic
fatty
liver
(NAFLD).
Statins
the
first-line
drugs
for
treatment
dyslipidemia.
However,
a
substantial
proportion
patients
cannot
reach
recommended
LDL-c
level
even
highest
tolerated
doses
statins,
there
is
no
available
drug
specifically
NAFLD
therapy.
Sea
cucumbers
one
widely
distributed
invertebrates,
an
important
resource
food
medicine.
have
many
valuable
nutrients
saponins,
acids,
phospholipids,
cerebrosides,
sulfated
polysaccharides,
well
proteins
peptides.
In
recent
years,
these
natural
products
derived
from
sea
attracted
attentions
CVD
because
their
lipid-lowering
effect
low
toxicity.
hypolipidemic
mechanisms
action
structure-activity
relationship
bioactive
components
not
been
well-documented
in
literature.
This
review
article
summarizes
signaling
pathways
potential
cucumber-derived
compounds
carbohydrates
peptides
proteins.
will
provide
information
useful
development
investigation
other
resources.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 20
Опубликована: Авг. 17, 2024
Lactic
acid
bacteria
(LAB)
are
the
main
probiotics
currently
available
in
markets
and
essential
for
maintaining
gut
health.
To
guarantee
probiotic
function,
it
is
imperative
to
boost
culture
yield
of
organisms,
ensure
sufficient
viable
cells
commercial
products,
or
develop
effective
prebiotics.
Recent
studies
have
shown
that
protein
hydrolysates
their
derived
peptides
promote
proliferation
Protein and Peptide Letters,
Год журнала:
2024,
Номер
31(8), С. 569 - 585
Опубликована: Авг. 28, 2024
Marine
organisms
represent
promising
bioactive
peptide
resources
with
diverse
biological
activities
such
as
antioxidant,
antimicrobial,
antihypertensive,
anti-fatigue,
and
immunoregulatory
activities.
Despite
many
studies
on
marine
peptides,
there
is
a
dearth
of
comprehensive
review
articles
the
emerging
trends
that
encompass
production
techniques
applications
peptides.
In
this
review,
we
summarize
major
research
findings
related
to
encompassing
aspects
their
production,
purification,
activities,
nanotechnology-based
strategies,
potential
applications.
Enzymatic
hydrolysis
currently
stands
out
most
commonly
used
method
for
producing
peptides;
downstream
purification
process
often
includes
combination
multiple
techniques.
Due
properties,
peptides
have
garnered
considerable
interest
industrial
active
ingredients
in
food,
pharmaceutical,
cosmetics
industries.
Additionally,
incorporation
encapsulation
strategies
nano
emulsion,
nanoliposome,
microemulsions
holds
promise
significantly
enhancing
bioavailability
bioactivity
Future
should
also
prioritize
systematic
identification
validation
health
benefits
by
both
vitro
vivo
animal
models,
along
conduct
human
clinical
trials.
Journal of Food Science,
Год журнала:
2025,
Номер
90(3)
Опубликована: Март 1, 2025
Colitis,
a
troublesome
inflammatory
disease
that
significantly
impacts
daily
life,
has
garnered
considerable
attention
in
recent
times.
Protolysates
play
crucial
role
the
treatment
of
colitis,
and
intestines
ovum
Cucumaria
frondosa
represent
readily
available
source
these
hydrolysates.
However,
effects
C.
hydrolysates
(CFHs)
on
colitis
have
not
been
thoroughly
investigated.
We
initially
examined
molecular
weight
distribution
CFHs
found
fraction
molecules
with
less
than
1000
Da
accounted
for
86.98%,
indicating
hydrolysis
primarily
produced
oligopeptides.
Subsequently,
we
employed
dextran
sulfate
sodium-induced
experimental
model
to
assess
therapeutic
potential
CFHs.
The
findings
indicated
preventive
administration
dramatically
attenuated
pathological
manifestations
associated
mice,
including
loss,
colon
shortening,
tissue
damage.
Furthermore,
suppressed
secretion
pro-inflammatory
cytokines
IL-6,
TNF-α,
IL-1β,
as
well
MPO
tissue.
Metagenomic
sequencing
demonstrated
could
restore
balance
dysregulated
gut
microbiota
by
reinforcing
Bacteroidota
suppressing
Verrucomicrobia
populations,
impacting
various
microbial
functions.
Metabolomic
analyses
further
revealed
exhibited
more
efficacious
modulatory
effect
DSS-induced
metabolic
abnormalities,
amino
acid
biosynthesis,
linoleic
metabolism,
dopaminergic
synapses.
In
conclusion,
showed
promise
alleviating
laying
groundwork
development
application
functional
food
relief.
