Food Chemistry, Год журнала: 2024, Номер 463, С. 141096 - 141096
Опубликована: Сен. 2, 2024
Язык: Английский
Applied Microbiology and Biotechnology, Год журнала: 2024, Номер 108(1)
Опубликована: Янв. 20, 2024
Язык: Английский
Процитировано
8
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Июнь 19, 2024
Introduction Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Due to its complex pathogenesis, new therapeutic agents are urgently needed. Orthosiphon aristatus (Blume) Miq., commonly known as kidney tea, widely used in DN treatment China. However, mechanisms have not been fully elucidated. Methods We db/db mice model and evaluated efficacy tea by measuring fasting blood glucose (FBG), serum inflammatory cytokines, injury indicators histopathological changes. Furthermore, 16S rDNA gene sequencing, untargeted metabolomics, electron microscope, ELISA, qRT-PCR, Western blotting were performed explore which exerted effects. Results Twelve polyphenols identified from extract ameliorated FBG, inflammation mice. Moreover, reshaped gut microbiota, reduced abundance Muribaculaceae , Lachnoclostridium Prevotellaceae_UCG-001 Corynebacterium Akkermansia enriched Alloprevotella Blautia Lachnospiraceae_NK4A136_group . Kidney altered levels metabolites pathways such ferroptosis, arginine biosynthesis mTOR signaling pathway. Importantly, improved mitochondrial damage, increased SOD activity, decreased MDA 4-HNE tissues Meanwhile, this functional upregulated GPX4 FTH1 expression downregulated ACSL4 NCOA4 expression, indicating that it could inhibit ferroptosis kidneys. Conclusion Our findings imply can attenuate development modulating microbiota presents a novel scientific rationale for clinical application tea.
Язык: Английский
Процитировано
7
Cancer Letters, Год журнала: 2025, Номер unknown, С. 217459 - 217459
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Frontiers in Microbiology, Год журнала: 2022, Номер 13
Опубликована: Дек. 2, 2022
In this study, we aimed to characterize the anti-type 2 diabetes (T2D) effects of Gastrodia elata Blume extract (GEBE) and determine whether these are mediated through modification gut microbiota bile acids. Mice were fed a high-fat diet (HFD), with or without GEBE, found that GEBE significantly ameliorated HFD-induced hyperglycemia, insulin resistance, inflammation by upregulating glucose transporter 4 (GLUT4) inhibiting toll-like receptor 4-nuclear factor kappa-B signaling pathway in white adipose tissue (WAT). addition, increased abundance Faecalibaculum Lactobacillus, altered serum acid concentrations, significant increase deoxycholic acid. The administration combined antibiotics mice eliminate their intestinal caused loss protective GEBE. Taken together, findings suggest ameliorates T2D increasing GLUT4 expression WAT, remodeling microbiota, modifying concentrations.
Язык: Английский
Процитировано
8
Clinical and Translational Discovery, Год журнала: 2023, Номер 3(1)
Опубликована: Фев. 1, 2023
Abstract There is a myriad of phytocomponents in various medicinal herbs, and some these substances have low absolute oral bioavailability. complex nuanced interaction between metabolic profiles gut microbiota that influences human health illness. An important component alternative complementary care the use herbs for therapeutic purposes. Expanding facets from numerous scientific discoveries mentioned potential linkage intestinal curative capabilities beneficial components upon their recognition. strong host at mucosal barrier gastrointestinal tract. This reinforces notion it to consider effects relation flora disorders, including type 2 diabetes. has been an explosion number coming into spotlight with already recognised as having anti‐diabetic effects, such increased insulin sensitivity decreased blood sugar levels. The review sites' assertion altering microbial community by intervention tactics modulate using major emphasis only on flavonoids, alkaloids, glycosides, terpenoids may very well be relevant T2DM rehabilitation indeed relevant. goal this present overview impacts prevention treatment diabetes modifying healthier manner. Based available literature, order gain deeper understanding how integrate specialised treatments are based bacteria mainstream clinical practice, aimed providing comprehensive pathogenesis progression T2DM, more thoughtful strategies manipulate integral part strategies.
Язык: Английский
Процитировано
4
Molecules, Год журнала: 2022, Номер 27(21), С. 7192 - 7192
Опубликована: Окт. 24, 2022
Type 2 diabetes mellitus is considered to be a substantial socioeconomic burden worldwide on both patients and governments. Coumarins are biomolecules with diversity of biological activities. The current investigation aimed explore the ameliorative effects cichoriin, which type coumarin, high-fat diet/streptozotocin (HFD/STZ)-induced diabetic rats. Methods: Rats were allocated into five groups. Group I was as control group, while other groups HFD/STZ-induced II assigned control. Groups III IV treated cichoriin (50 or 100 mg/kg, respectively). V received glibenclamide (5 mg/kg) (as positive control). blood glucose (BG), serum insulin, triglycerides (TG), total cholesterol (TC), antioxidant capacity (TAC), catalase, hepatic superoxide dismutase (SOD) content malondialdehyde (MDA) assessed. Histopathological immunohistochemistry analysis pancreatic tissue performed. mRNA protein expressions GLUT4, AMPK, PI3K estimated. Results: Cichoriin treatment ameliorated conditions mitigated histopathological characteristics pancreas, well increasing insulin expression. This decreased levels BG, TG, TC, MDA improved TAC, catalase SOD contents. demonstrated upregulation PI3K. in silico binding supported possible Conclusion: Collectively, this work highlighted potential role mitigating showed it valuable product.
Язык: Английский
Процитировано
5
Antioxidants, Год журнала: 2023, Номер 12(8), С. 1643 - 1643
Опубликована: Авг. 20, 2023
Essential oils sourced from herbs commonly used in the Mediterranean diet have demonstrated advantageous attributes as nutraceuticals and prebiotics within a model of severe cardiometabolic disorder. The primary objective this study was to assess influences exerted by essential derived thyme (
Язык: Английский
Процитировано
2
Journal of Biobased Materials and Bioenergy, Год журнала: 2024, Номер 18(5), С. 771 - 794
Опубликована: Март 29, 2024
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that escalating globally and imposing substantial burden on patients society. Given the increasing prevalence of T2DM inadequacy conventional therapeutic options, plant extracts have garnered significant attention as natural medicines. These primarily encompass polyphenols, alkaloids, polysaccharides. This review assesses efficacy these in preventing treating its complications by collecting analyzing relevant clinical trials human studies to elucidate their mechanisms action. Additionally, it highlights role adjunctive therapies management while underscoring promising applications practice. However, caution should be exercised due potential risks associated with use extracts; further evaluation regarding toxicities interactions warranted. We anticipate our comprehensive will offer improved treatment options for inspiring advancements botanical medicine.
Язык: Английский
Процитировано
0
Food Chemistry, Год журнала: 2024, Номер 463, С. 141096 - 141096
Опубликована: Сен. 2, 2024
Язык: Английский
Процитировано
0