Journal of Medicinal Food,
Год журнала:
2024,
Номер
27(10), С. 931 - 939
Опубликована: Июль 26, 2024
Ulcerative
colitis
(UC)
is
a
subtype
of
inflammatory
bowel
disease
affecting
the
colon
with
idiopathic
origin.
Melinjo
endosperm
extract
(MeE)
contains
polyphenolic
compounds
that
have
antioxidative
and
anticancer
properties.
We
examined
effect
MeE
on
inflammation
mucin
expression
in
colons
UC
mice
treated
dextran
sulfate
sodium
(DSS).
C57BL/6J
male
were
assigned
into
four
categories:
control,
DSS
+
0%
MeE,
0.1%
0.5%
MeE.
The
control
group
was
provided
distilled
water
standard
chow
diet
for
4
weeks.
In
groups,
3
weeks
followed
by
diets
drinking
containing
3%
week.
Macrophage
count,
mucus
area
stained
Alcian
blue
(AB),
levels
adenosine
monophosphate-activated
protein
kinase
(AMPK),
nuclear
factor-κB
(NFκB)
p65,
silent
information
regulator
(Sirt)
1
expression,
as
well
proinflammatory
mediators
Mucin
2
mRNA
assessed.
group,
AB-stained
areas
observed
to
be
lower
than
those
controls.
However,
+0.5%
significantly
increased.
Compared
macrophage
number,
IL-1β
mRNA,
NFκB
p65
showed
significant
increase.
Conversely,
these
decreased
group.
phosphorylated
AMPK
Sirt1
upregulated
conclusion,
may
alleviate
injury
reducing
infiltration
regulating
AMPK/NFκB/Sirt1
pathway.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(23), С. 15279 - 15279
Опубликована: Дек. 3, 2022
The
plant-based
nutraceuticals
are
receiving
increasing
interest
in
recent
time.
high
attraction
to
the
phytochemicals
is
associated
with
their
anti-inflammatory
and
antioxidant
activities,
which
can
lead
reduced
risk
of
development
cardiovascular
other
non-communicable
diseases.
One
most
disseminated
groups
plant
bioactives
phenolic
compounds.
It
was
recently
hypothesized
that
compounds
have
ability
improve
functioning
gut
barrier.
available
studies
showed
one
polyphenols,
resveratrol,
has
great
potential
integrity
Very
promising
results
been
obtained
vitro
animal
models.
Still,
more
clinical
trials
must
be
performed
evaluate
effect
resveratrol
on
barrier,
especially
individuals
increased
intestinal
permeability.
Moreover,
interplay
between
compounds,
microbiota
barrier
should
carefully
evaluated
future.
Therefore,
this
review
offers
an
overview
current
knowledge
about
interaction
polyphenols
a
special
emphasis
summarizes
methods
permeability,
discusses
research
gaps
proposes
directions
for
future
area.
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(19), С. 7566 - 7574
Опубликована: Май 2, 2023
Resveratrol
and
its
analogs
are
phytochemicals.
Human
3β-hydroxysteroid
dehydrogenase
1
(3β-HSD1)
synthesizes
steroid
hormones
for
normal
pregnancy
or
promoting
cancer
metastasis.
Whether
they
inhibit
3β-HSD1
remains
unclear.
In
this
study,
the
inhibitory
potency,
mode
of
action,
structure-activity
relationship,
docking
parameters
resveratrol
on
rat
homolog
3β-HSD4
were
analyzed.
The
potency
these
chemicals
human
was
4,4'-dihydroxystilbene
(IC50,
3.68
μM)
>
pinostilbene
(8.07
pinosylvin
(10.60
lunularin
(26.84
(30.20
dihydroresveratrol
(>100
=
oxyresveratrol
dihydropinosylvin
(ineffective
at
100
μM).
metabolites
mixed
competitive
inhibitors
3β-HSD1.
inhibited
progesterone
secretion
by
JAr
cells
≥1
μM.
32.09
(34.71
significantly
placental
activity.
Docking
analysis
shows
that
bind
steroid-binding
sites
interact
with
catalytic
residues
Ser125/Thr125
Tyr155.
negative
correlation
LogP
IC50
values
indicates
lipophilicity
plays
a
critical
role
in
effect
chemicals.
conclusion,
4,4'-dihydroxystilbene,
pinostilbene,
effectively
depending
their
lipophilicity,
thereby
acting
as
potential
therapeutic
agents.
Journal of Medicinal Food,
Год журнала:
2024,
Номер
27(10), С. 931 - 939
Опубликована: Июль 26, 2024
Ulcerative
colitis
(UC)
is
a
subtype
of
inflammatory
bowel
disease
affecting
the
colon
with
idiopathic
origin.
Melinjo
endosperm
extract
(MeE)
contains
polyphenolic
compounds
that
have
antioxidative
and
anticancer
properties.
We
examined
effect
MeE
on
inflammation
mucin
expression
in
colons
UC
mice
treated
dextran
sulfate
sodium
(DSS).
C57BL/6J
male
were
assigned
into
four
categories:
control,
DSS
+
0%
MeE,
0.1%
0.5%
MeE.
The
control
group
was
provided
distilled
water
standard
chow
diet
for
4
weeks.
In
groups,
3
weeks
followed
by
diets
drinking
containing
3%
week.
Macrophage
count,
mucus
area
stained
Alcian
blue
(AB),
levels
adenosine
monophosphate-activated
protein
kinase
(AMPK),
nuclear
factor-κB
(NFκB)
p65,
silent
information
regulator
(Sirt)
1
expression,
as
well
proinflammatory
mediators
Mucin
2
mRNA
assessed.
group,
AB-stained
areas
observed
to
be
lower
than
those
controls.
However,
+0.5%
significantly
increased.
Compared
macrophage
number,
IL-1β
mRNA,
NFκB
p65
showed
significant
increase.
Conversely,
these
decreased
group.
phosphorylated
AMPK
Sirt1
upregulated
conclusion,
may
alleviate
injury
reducing
infiltration
regulating
AMPK/NFκB/Sirt1
pathway.
