Very low-carbohydrate diet with higher protein ratio improves lipid metabolism and inflammation in rats with diet-induced nonalcoholic fatty liver disease

The Journal of Nutritional Biochemistry, Год журнала: 2024, Номер 126, С. 109583 - 109583

Опубликована: Янв. 18, 2024

Язык: Английский

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Non-targeted metabolomics reveals a modulatory effect of DHA-enriched phosphatidylserine in high fat-diet induced non-alcoholic fatty liver disease in mice

Process Biochemistry, Год журнала: 2023, Номер 135, С. 22 - 32

Опубликована: Ноя. 7, 2023

Язык: Английский

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Fucoxanthin Mitigates High-Fat-Induced Lipid Deposition and Insulin Resistance in Skeletal Muscle through Inhibiting PKM1 Activity

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(32), С. 18013 - 18026

Опубликована: Авг. 1, 2024

Glucose and lipid metabolism dysregulation in skeletal muscle contributes to the development of metabolic disorders. The efficacy fucoxanthin alleviating disorders remains poorly understood. In this study, we systematically investigated impact on mitigating deposition insulin resistance employing palmitic acid-induced C2C12 cells ob/ob mice. Fucoxanthin significantly alleviated PA-induced resistance. addition, prominently upregulated expression metabolism-related genes (Pparα Cpt-1), promoting fatty acid β-oxidation metabolism. Additionally, increased Pgc-1α Tfam, elevated mtDNA/nDNA ratio, reduced ROS levels. Further, identified pyruvate kinase isozyme 1 (PKM1) as a high-affinity protein for by drug affinity-responsive target stability LC–MS confirmed their robust interaction CETSA, microscale thermophoresis, circular dichroism. Supplementation with pyruvate, product PKM1, attenuated beneficial effects Mechanistically, glucose glycolysis rate enhanced mitochondrial biosynthesis through inhibiting PKM1 activity, thereby stress. These findings present novel clinical strategy treating diseases using fucoxanthin.

Язык: Английский

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Laminaria japonica Aresch-Derived Fucoidan Ameliorates Hyperlipidemia by Upregulating LXRs and Suppressing SREBPs

Cardiovascular Therapeutics, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, hyperlipidemia one major inducing factor CVD. It worthy to note that fucoidans are reported have hypolipidemic activity with species specificity; however, underlying mechanisms action far from clarification. This study aimed at investigating plasma lipid‐lowering fucoidan L. japonica Aresch by detecting levels hepatic genes involved in lipid metabolism. Our results demonstrated F3 significantly lowered total cholesterol triglyceride C57BL/6J mice fed a high‐fat diet. In mouse liver, intervention increased gene expression peroxisome proliferator‐activated receptor (PPAR) α , liver X (LXR) β ATP‐binding cassette transporter (ABC) G1 G8 decreased proprotein convertase subtilisin/kexin type 9 (PCSK9), low‐density lipoprotein receptor, 7 alpha‐hydroxylase A1, sterol regulatory element‐binding protein (SREBP) 1c SREBP‐2. These antihyperlipidemic effects related its activation PPAR LXR/ABC signaling pathways inactivation SREBPs. conclusion, may be explored as potential compound for prevention or treatment disorders.

Язык: Английский

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Gradient experiment reveals physiological stress from heavy metal zinc on the economically valuable seaweed Sargassum fusiforme

Marine Environmental Research, Год журнала: 2025, Номер 204, С. 106958 - 106958

Опубликована: Янв. 8, 2025

Язык: Английский

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Marine natural products as an important source of bioactive substances for non-alcoholic fatty liver disease management

Frontiers in Marine Science, Год журнала: 2025, Номер 11

Опубликована: Янв. 28, 2025

With an estimated global prevalence of 32.4%, non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent chronic condition. The marine ecosystem, distinguished by its distinctive environmental characteristics, a treasure trove novel lead compounds possessing unique chemical structures, offering promising avenues for development new therapeutic agents or dietary supplement targeting NAFLD. Marine bioactive substances from natural products, such as polysaccharides, polyphenols, polyunsaturated acids, and peptides, have been shown to benefit health alleviating metabolic dysfunction through multiple mechanisms. This paper reviews effects various entities, including fauna, flora, microorganisms, on regulation A brief overview predominant pathogenic mechanisms underlying also provided, thereby establishing critical link between potential management

Язык: Английский

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Protective effects of Trifuhalol a, a Phlorotannin derived from edible Brown seaweed Agarum cribrosum, on dexamethasone-induced muscle atrophy in muscle cells and zebrafish models

Food Research International, Год журнала: 2025, Номер 209, С. 116303 - 116303

Опубликована: Март 22, 2025

Язык: Английский

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Fucoxanthin Targets β1 Integrin to Disrupt Adhesion and Migration in Human Glioma Cells

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Glioblastoma, the most aggressive type of primary brain tumor, is marked by high invasiveness and metastasis, posing significant challenges in treatment. Fucoxanthin, a carotenoid derived from brown macroalgae, has demonstrated therapeutic potential cancer therapy; however, its precise mechanisms action remain unclear. In this study, we explored inhibitory effects fucoxanthin on integrin-mediated adhesion migration human glioma U-87 MG cells, shedding light antimetastatic properties. Our data indicated that at 1 μM did not affect cell viability but inhibited cells to fibronectin, key extracellular matrix (ECM) ligand for integrins, without affecting poly-l-lysine, nonintegrin ligand, indicating selective impact adhesion. Fucoxanthin treatment significantly reduced size number focal adhesions (FA), which play central role migration. addition, impaired migratory capacity, including accumulated distance velocity, determined time-lapse videomicroscopy. Further, remarkably integrin engagement-mediated actin polymerization, Vav3 phosphorylation, downstream activation Rac1, FAK, paxillin, further supporting disrupting signaling cytoskeletal remodeling. Additionally, complementary experiments utilizing protein binding assays, competitive ELISA, CETSA, DARTS, MST collectively confirmed direct interaction between β1 as well affinity fibronectin. The theoretical model molecular docking dynamics simulation align with our experimental findings, providing plausible mechanism competitively inhibits summary, study highlights promising agent impairs glioblastoma directly targeting pathways. These findings offer valuable insights into an

Язык: Английский

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Integrating untargeted metabolomics and computational docking for biomarker evaluation: A case study on marine algae-derived ligands

Bioorganic Chemistry, Год журнала: 2025, Номер 161, С. 108539 - 108539

Опубликована: Апрель 30, 2025

Язык: Английский

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Codonopsis pilosula polysaccharides attenuate lipid accumulation and inflammatory response in the NAFLD mouse by regulating AMPK/ACC/SREBP1 signaling pathway

Tissue and Cell, Год журнала: 2025, Номер unknown, С. 102984 - 102984

Опубликована: Май 1, 2025

Язык: Английский

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