European Journal of Neuroscience,
Год журнала:
2024,
Номер
60(4), С. 4661 - 4683
Опубликована: Июль 23, 2024
Abstract
Post‐traumatic
stress
disorder
(PTSD)
is
a
complex
psychological
provoked
by
distressing
experiences,
and
it
remains
without
highly
effective
intervention
strategies.
The
exploration
of
PTSD's
underlying
mechanisms
crucial
for
advancing
diagnostic
therapeutic
approaches.
Current
studies
primarily
explore
PTSD
through
the
lens
central
nervous
system,
investigating
concrete
molecular
alterations
in
cerebral
area
neural
circuit
irregularities.
However,
body's
response
to
external
stressors,
particularly
changes
cardiovascular
function,
often
pronounced,
evidenced
notable
cardiac
dysfunction.
Consequently,
examining
with
focus
on
function
vital
early
prevention
targeted
management
disorder.
This
review
undertakes
comprehensive
literature
analysis
detail
brain
heart
structures
functions
associated
PTSD.
It
also
synthesizes
potential
heart–brain
axis
interactions
relevant
development
Ultimately,
considering
this
proposes
novel
perspectives
prophylaxis
therapy.
European Journal of Neuroscience,
Год журнала:
2024,
Номер
60(4), С. 4661 - 4683
Опубликована: Июль 23, 2024
Abstract
Post‐traumatic
stress
disorder
(PTSD)
is
a
complex
psychological
provoked
by
distressing
experiences,
and
it
remains
without
highly
effective
intervention
strategies.
The
exploration
of
PTSD's
underlying
mechanisms
crucial
for
advancing
diagnostic
therapeutic
approaches.
Current
studies
primarily
explore
PTSD
through
the
lens
central
nervous
system,
investigating
concrete
molecular
alterations
in
cerebral
area
neural
circuit
irregularities.
However,
body's
response
to
external
stressors,
particularly
changes
cardiovascular
function,
often
pronounced,
evidenced
notable
cardiac
dysfunction.
Consequently,
examining
with
focus
on
function
vital
early
prevention
targeted
management
disorder.
This
review
undertakes
comprehensive
literature
analysis
detail
brain
heart
structures
functions
associated
PTSD.
It
also
synthesizes
potential
heart–brain
axis
interactions
relevant
development
Ultimately,
considering
this
proposes
novel
perspectives
prophylaxis
therapy.
