Anti-inflammation mechanisms of a homogeneous polysaccharide from Phyllanthus emblica L. on DSS induced colitis mice via the gut microbiota and metabolites alteration

Food Chemistry, Год журнала: 2024, Номер 459, С. 140346 - 140346

Опубликована: Июль 4, 2024

Язык: Английский

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Resveratrol Improves Hyperuricemia and Ameliorates Renal Injury by Modulating the Gut Microbiota

Nutrients, Год журнала: 2024, Номер 16(7), С. 1086 - 1086

Опубликована: Апрель 7, 2024

Resveratrol (RES) has been reported to prevent hyperuricemia (HUA); however, its effect on intestinal uric acid metabolism remains unclear. This study evaluated the impact of RES in mice with HUA induced by a high-fat diet (HFD). Moreover, we revealed underlying mechanism through metagenomics, fecal microbiota transplantation (FMT), and 16S ribosomal RNA analysis. We demonstrated that reduced serum acid, creatinine, urea nitrogen, urinary protein levels, improved glomerular atrophy, unclear renal tubule structure, fibrosis, inflammation. The results also showed increased degradation. significantly changed flora composition HFD-fed enriching beneficial bacteria degrade reducing harmful promote inflammation, improving microbial function via upregulation purine metabolism. FMT further is essential for HUA, Lactobacillus may play key role this process. present alleviates HFD-induced injury regulating gut acid.

Язык: Английский

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Berberine: An inspiring resource for the treatment of colorectal diseases

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 167, С. 115571 - 115571

Опубликована: Сен. 25, 2023

Colorectal cancer is a prevalent malignant tumor with complex and diverse pathogenesis. In recent years, natural products have shown promising application prospects as sources of anticancer drugs. BBR, class benzoquinoline alkaloids extracted from various plants, widely used in disease treatments owing to its pharmacological activities, including antibacterial, anti-inflammatory, antioxidant, anticancer, anti-angiogenesis properties. Research has demonstrated that BBR exerts an anti-Salmonella -Escherichia coli infection effect, attenuating inflammatory reactions by inhibiting harmful bacteria. During the stage colorectal precancerous lesions, inhibits activity cell cyclin regulating PI3K/AKT, MAPK, Wnt signaling pathways, thereby decelerating cycle progression polyp or adenoma cells. Moreover, inhibitory effect on primarily occurs through regulation cycle, anti-angiogenesis, gut microbiota, antioxidant pathways. The specific involved pathways include MPK/ERK, NF-kB, EGFR encompassing Bcl-2 family proteins, vascular endothelial growth factor, superoxide dismutase. This study reviews summarizes, for first time, mechanisms action carcinogenesis process cancer, providing novel insights clinical intestinal diseases.

Язык: Английский

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Non-targeted metabolomics reveals a modulatory effect of DHA-enriched phosphatidylserine in high fat-diet induced non-alcoholic fatty liver disease in mice

Process Biochemistry, Год журнала: 2023, Номер 135, С. 22 - 32

Опубликована: Ноя. 7, 2023

Язык: Английский

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Discovery of baicalein derivatives as novel inhibitors against human pancreatic lipase: Structure-activity relationships and inhibitory mechanisms

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 275, С. 133523 - 133523

Опубликована: Июнь 29, 2024

Язык: Английский

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Chitosan-Stabilized Selenium Nanoparticles Alleviate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Modulating the Gut Barrier Function and Microbiota

Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(8), С. 236 - 236

Опубликована: Авг. 22, 2024

Low molecular weight chitosan selenium nanoparticles (LCS-SeNPs), a biologically active compound derived from polysaccharides, have demonstrated potential in addressing obesity. However, the mechanism through which LCS-SeNPs alleviate high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) remains unclear. Our results elucidated that significantly inhibited fat accumulation and markedly improved intestinal barrier by increasing mucus secretion goblet cells. Moreover, reshaped flora composition abundance of mucus-associated microbiota (Bifidobacterium, Akkermansia, Muribaculaceae_unclassified) decreasing obesity-contributed bacterium (Anaerotruncus, Lachnoclostridium, Proteus). The modulation influenced several metabolic pathways, including bile acid secretion, purine metabolites, tryptophan derivation. Meanwhile, glycocholic tauro-beta-muricholic were reduced LCS-SeNP group. study suggests crucial role metabolism, providing new theoretical foundation for utilizing polysaccharides intervention HFD-induced NAFLD.

Язык: Английский

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Research Progress on Hypoglycemic Effects and Molecular Mechanisms of Flavonoids: A Review

Antioxidants, Год журнала: 2025, Номер 14(4), С. 378 - 378

Опубликована: Март 22, 2025

As a prevalent metabolic disorder, the increasing incidence of diabetes imposes significant burden on global healthcare. Flavonoids in natural phytochemical products exhibit notable hypoglycemic properties, making them potential alternatives for treatment. This article summarizes properties flavonoid subcategories studied recent years, including flavones, isoflavones, flavonols, flavanols, and others. The relevant targets signal pathways, such as α-amylase, α-glucosidase, insulin receptor substrate (IRS)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), PKR-like endoplasmic reticulum (PERK)/eukaryotic initiation factor 2α (eIF2α)/activation transcription 4 (ATF4)/C/EBP homologous protein (CHOP), etc., are also elaborated. Additionally, flavonoids have been demonstrated to modulate gut microbiota its metabolites. Through aforementioned mechanisms, mainly suppress carbohydrate metabolism gluconeogenesis; facilitate glucose uptake, glycogenesis, secretion; mitigate resistance, oxidative stress, inflammation, etc. Notably, several studies indicated that certain displayed synergistic effects. In conclusion, this provides comprehensive review effects investigated aiming offer theoretical insights their further exploration.

Язык: Английский

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Bile-processed Rhizoma Coptidis alleviates type 2 diabetes mellitus through modulating the gut microbiota and short-chain fatty acid metabolism

International Immunopharmacology, Год журнала: 2025, Номер 156, С. 114645 - 114645

Опубликована: Апрель 19, 2025

Язык: Английский

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Rebaudioside D decreases adiposity and hepatic lipid accumulation in a mouse model of obesity

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 6, 2024

Abstract Overconsumption of added sugars has been pointed out as a major culprit in the increasing rates obesity worldwide, contributing to rising popularity non-caloric sweeteners. In order satisfy growing demand, industrial efforts have made purify sweet-tasting molecules found natural sweetener stevia, which are characterized by sweet taste free unpleasant aftertaste. Although use artificial sweeteners raised many concerns regarding metabolic health, impact purified stevia components on latter remains poorly studied. The objective this project was evaluate two rebaudioside A and D (RebA RebD), development obesity, insulin resistance, hepatic bile acid profile, gut microbiota mouse model diet-induced obesity. Male C57BL/6 J mice were fed an obesogenic high-fat/high-sucrose (HFHS) diet orally treated with 50 mg/kg RebA, RebD or vehicle (water) for 12 weeks. An additional group chow-fed included healthy reference. At weeks 10 12, oral glucose tolerance tests performed. Liver lipids content analyzed. Whole-genome shotgun sequencing performed profile microbiota. Bile acids measured feces, plasma, liver. lipid gene expression As compared HFHS-vehicle treatment group, administered showed reduced weight gain, evidenced decreased visceral adipose tissue weight. triglycerides cholesterol from RebD-treated lower peroxidation decreased. Interestingly, administration associated significant enrichment Faecalibaculum rodentium increased secondary metabolism. Moreover, level lipopolysaccharide-binding protein (LBP). Neither RebA nor treatments homeostasis. daily consumption no detrimental effects health. contrast, reduce adiposity, alleviate steatosis peroxidation, decrease LBP, marker endotoxemia

Язык: Английский

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Comprehensive assessment of rice bran dietary fiber on gut microbiota composition and metabolism during in vitro fermentation

Food Research International, Год журнала: 2024, Номер 197, С. 115231 - 115231

Опубликована: Окт. 30, 2024

Язык: Английский

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