Transcription factor CREB/ATF regulates overexpression of CYP6CY14 conferring resistance to cycloxaprid in Aphis gossypii
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140634 - 140634
Опубликована: Фев. 1, 2025
Язык: Английский
Enthralling genetic regulatory mechanisms meddling insecticide resistance development in insects: role of transcriptional and post-transcriptional events
Chandramohan Muthu Lakshmi Bavithra,
M. Murugan,
Shanmugasundaram Pavithran
и другие.
Frontiers in Molecular Biosciences,
Год журнала:
2023,
Номер
10
Опубликована: Сен. 6, 2023
Insecticide
resistance
in
insects
severely
threatens
both
human
health
and
agriculture,
making
insecticides
less
compelling
valuable,
leading
to
frequent
pest
management
failures,
rising
input
costs,
lowering
crop
yields,
disastrous
public
health.
results
from
multiple
factors,
mainly
indiscriminate
insecticide
usage
mounted
selection
pressure
on
insect
populations.
Insects
respond
stress
at
the
cellular
level
by
modest
yet
significant
genetic
propagations.
Transcriptional,
co-transcriptional,
post-transcriptional
regulatory
signals
of
cells
organisms
regulate
intricate
processes
gene
expressions
churning
information
transcriptional
units
into
proteins
non-coding
transcripts.
Upregulation
detoxification
enzymes,
notably
cytochrome
P450s
(CYPs),
glutathione
S-transferases
(GSTs),
esterases
[carboxyl
choline
esterase
(CCE),
carboxyl
(CarE)]
ATP
Binding
Cassettes
(ABC)
level,
modification
target
sites,
decreased
penetration,
or
higher
excretion
are
noted
physiological
responses.
The
pathways
such
as
AhR/ARNT,
Nuclear
receptors,
CncC/Keap1,
MAPK/CREB,
GPCR/cAMP/PKA
were
found
genes
level.
Post-transcriptional
changes
RNAs
(ncRNAs)
microRNAs
(miRNA),
long
(lncRNA),
epitranscriptomics,
including
RNA
methylation,
reported
resistant
insects.
Additionally,
modifications
mutations
sites
copy
number
variations
(CNV)
also
influencing
resistance.
Therefore,
these
intricacies
may
decrease
sensitivity,
altering
concentrations
activities
involved
interactions
detoxification.
episodes
levels
pertinent
responses
extensively
covered
this
review.
An
overview
molecular
mechanisms
underlying
biological
rhythms
allows
for
developing
alternative
control
methods
focus
vulnerabilities,
employing
reverse
genetics
approaches
like
interference
(RNAi)
technology
silence
particular
resistance-related
sustained
management.
Язык: Английский
Nicotinamide deficiency promotes imidacloprid resistance via activation of ROS/CncC signaling pathway-mediated UGT detoxification in Nilaparvata lugens
Mengqing Deng,
Tianxiang Xiao,
Xiyue Xu
и другие.
The Science of The Total Environment,
Год журнала:
2024,
Номер
926, С. 172035 - 172035
Опубликована: Март 31, 2024
Язык: Английский
The cross‐resistance to etofenprox in Nilaparvata lugens with a high adaptability to resistant rice variety IR56
Xiaowei Yuan,
Tianshun He,
Jianzheng Zou
и другие.
Pest Management Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 16, 2025
The
application
of
resistant
rice
varieties
and
insecticides
represents
two
crucial
strategies
for
managing
the
brown
planthopper
(BPH),
Nilaparvata
lugens
(Stål).
Insects
often
employ
similar
detoxification
mechanisms
to
metabolize
plant
secondary
metabolites
insecticides,
which
poses
a
potential
risk
that
BPH
population
adapted
may
also
obtain
resistance
some
insecticides.
Here
in
(R-IR56)
has
variety
IR56
through
continuous
selection,
moderate
etofenprox
was
observed.
Insect
P450s
contribute
insecticide
insects.
Through
transcriptome
sequencing
R-IR56
control
populations,
it
found
P450
genes,
CYP439A1
CYP439A2,
were
over-expressed
R-IR56.
RNA
interference
confirmed
importance
vivo.
metabolite
identification
catalytic
activity
recombinant
proteins
revealed
metabolism
by
both
CYP439A2
vitro,
catalyzed
an
O-de-ethylation
on
etofenprox.
However,
up-regulation
genes
did
not
adaptation
variety.
study
reveals
exhibits
level
etofenprox,
but
cross-resistance
is
unidirectional.
findings
here
provide
theoretical
guidance
integrated
pest
management
strategy,
especially
focusing
interplay
between
applications
©
2025
Society
Chemical
Industry.
Язык: Английский
JNK-ERK Synergistic Regulation of P450 Gene Expression Confers Nitenpyram Resistance in Nilaparvata lugens (Stål)
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Cascading
regulation
of
signaling
pathways
plays
a
crucial
role
in
insect
growth,
development,
and
adaptation.
However,
how
insects
employ
cascades
to
regulate
detoxification
gene
expression
enhance
resistance
is
not
well
understood.
In
the
current
study,
we
investigated
MAPK
pathway
mediating
nitenpyram
Nilaparvata
lugens.
qRT-PCR
western-blot
analyses
revealed
that
both
transcription
protein
levels
NlJNK
NlERK
were
upregulated
resistant
strain,
these
changes
can
be
induced
by
exposure
nitenpyram.
Moreover,
P450
genes
including
NlCYP6ER1,
NlCYP302A1,
NlCYP6AY1,
which
closely
associated
with
resistance,
was
significantly
decreased
following
silencing
or
inhibitor
treatments.
Further
studies
showed
NlERK-NlJNK
comediated
factors
NlCREB
NlAP-1
expression.
These
findings
highlight
critical
N.
lugens
offer
potential
targets
for
insecticide
management.
Язык: Английский
FOXJ1 contributes to the resistance of Rhopalosiphum padi to pyrethroids by modulating the expression of P450 genes
Pesticide Biochemistry and Physiology,
Год журнала:
2025,
Номер
unknown, С. 106428 - 106428
Опубликована: Апрель 1, 2025
Язык: Английский
Akt-FoxO signaling drives co-adaptation to insecticide and host plant stresses in an herbivorous insect
Journal of Advanced Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Ongoing
interactions
between
host
and
herbivorous
insect
trigger
a
co-evolutionary
arms
race.
Genetic
diversity
within
insects
facilitates
their
adaptation
to
phytochemicals
derivatives,
including
plant-derived
insecticides.
Cytochrome
P450s
play
important
roles
in
metabolizing
insecticides,
due
almost
perfect
evolution.
Язык: Английский
CYP4CE1 Metabolized Nitenpyram through Two Types of Oxidation Reaction, Hydroxylation, and N-Demethylation
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(36), С. 20122 - 20129
Опубликована: Сен. 2, 2024
Nitenpyram,
taking
the
place
of
imidacloprid,
is
a
widely
used
neonicotinoid
insecticide
to
control
Язык: Английский
Roles of spermary-specific carboxylesterases in Nilaparvata lugens reproduction: Opposite between insecticide-induced upregulation and resistance-associated overexpression
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
unknown, С. 138991 - 138991
Опубликована: Дек. 1, 2024
Язык: Английский