Phthalates Induce Neurotoxicity by Disrupting the Mfn2-PERK Axis-Mediated Endoplasmic Reticulum–Mitochondria Interaction
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(13), С. 7411 - 7422
Опубликована: Фев. 23, 2024
Di-(2-ethylhexyl)
phthalate
(DEHP),
as
the
most
common
phthalate,
has
been
extensively
used
a
plasticizer
to
improve
plasticity
of
agricultural
products,
which
pose
severe
harm
human
health.
Mitochondrial
dynamics
and
endoplasmic
reticulum
(ER)
homeostasis
are
indispensable
for
maintaining
mitochondria-associated
ER
membrane
(MAM)
integrity.
In
this
study,
we
aimed
explore
effect
DEHP
on
nervous
system
its
association
with
ER-mitochondria
interaction.
Here,
showed
that
caused
morphological
changes,
motor
deficits,
cognitive
impairments,
blood-brain
barrier
disruption
in
brain.
triggered
stress,
is
mainly
mediated
by
protein
kinase
R-like
(PERK)
signaling.
Moreover,
DEHP-induced
mitofusin-2
(Mfn2)
downregulation
results
imbalance
mitochondrial
dynamics.
Interestingly,
exposure
impaired
MAMs
inhibiting
Mfn2-PERK
Above
all,
study
elucidates
axis-mediated
interaction
phthalate-induced
neurotoxicity
could
be
potentially
developed
novel
therapy
neurological
diseases.
Язык: Английский
Synergistic role of phenylpropanoid biosynthesis and citrate cycle pathways in heavy metal detoxification through secretion of organic acids
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
476, С. 135106 - 135106
Опубликована: Июль 4, 2024
Язык: Английский
Cadmium neurotoxicity and therapeutic strategies
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2024,
Номер
38(3)
Опубликована: Март 1, 2024
Abstract
Cadmium
(Cd)
is
a
multitarget,
carcinogenic,
nonessential
environmental
pollutant.
Due
to
its
toxic
effects
at
very
low
concentrations,
lengthy
biological
half‐life,
and
excretion
rate,
exposure
Cd
carries
concern.
Prolonged
causes
severe
injury
the
nervous
system
of
both
humans
animals.
Nevertheless,
precise
mechanisms
responsible
for
neurotoxic
have
yet
be
fully
elucidated.
The
accurate
chemical
mechanism
potentially
entails
destruction
metal‐ion
homeostasis,
inducing
oxidative
stress,
apoptosis,
autophagy.
Here
we
review
evidence
corresponding
strategies
protect
against
Cd‐induced
central
injury.
Язык: Английский
Vitamin E: An assistant for black soldier fly to reduce cadmium accumulation and toxicity
Environment International,
Год журнала:
2024,
Номер
185, С. 108547 - 108547
Опубликована: Март 1, 2024
Cadmium
(Cd)
is
a
toxic
heavy
metal
associated
with
osteoporosis,
liver,
and
kidney
disease.
The
black
solder
fly
(BSF)
Hermetia
illucens
may
be
exposed
to
Cd
during
the
transformation
of
livestock
manure.
BSF
has
high
tolerance
Cd.
In
previous
work
laboratory,
we
found
that
vitamin
E
(VE)
play
role
in
exposure.
main
findings
are
as
follows:
larvae
pretreated
exogenous
VE
had
heavier
body
weight,
lower
content
toxicity
under
similar
Even
exposure
at
concentrations
300
700
mg/kg
concentration
100
still
reduced
85.33
%
84.43
%,
respectively.
best-fitting
models
showed
metallothionein
(MT)
content,
oxidative
damage
(8-hydroxydeoxyguanosine
malondialdehyde
content),
antioxidant
power
(total
power,
peroxidase
activity)
great
influence
on
bioaccumulated
larvae.
degree
was
pretreatments.
This
variation
can
explained
by
their
changed
MT
increased
because
VE.
These
results
reveal
roles
insects
defense
against
provide
new
option
for
prevention
therapy
caused
Язык: Английский
Acupuncture regulates astrocyte neurotoxic polarization to protect blood–brain barrier integrity in delayed thrombolysis through mediating ERK1/2/Cx43 axis
IBRO Neuroscience Reports,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Cadmium disrupted homeostasis of proximal renal tubular cells via targeting ATF4-CHOP complex into the nucleus
Poultry Science,
Год журнала:
2025,
Номер
unknown, С. 105059 - 105059
Опубликована: Март 1, 2025
Язык: Английский
A novel NADP+-isocitrate dehydrogenase contributes to cadmium/lead detoxification and tolerance in plants
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 144094 - 144094
Опубликована: Май 1, 2025
Язык: Английский
The ins and outs of connexins and pannexins beyond the cell surface
Trends in Biochemical Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
Язык: Английский
Sulforaphane Ameliorate Cadmium-Induced Blood–Thymus Barrier Disruption by Targeting the PI3K/AKT/FOXO1 Axis
Yu-Xuan Tong,
Shi‐Yong Zhu,
Zhaoyi Wang
и другие.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(23), С. 13382 - 13392
Опубликована: Май 30, 2024
Cadmium
(Cd)
is
a
transition
metal
ion
that
extremely
harmful
to
human
and
animal
biological
systems.
Cd
toxic
substance
can
accumulate
in
the
food
chain
cause
various
health
issues.
Sulforaphane
(SFN)
natural
bioactive
compound
with
potent
antioxidant
properties.
In
our
study,
80
1
day-old
chicks
were
fed
(140
mg/kg
BW/day)
and/or
SFN
(50
for
90
days.
The
blood–thymus
barrier
(BTB)
selective
separating
T-lymphocytes
from
blood
cortical
capillaries
thymus
cortex.
Our
research
revealed
could
destroy
BTB
by
downregulating
Wnt/β-catenin
signaling
induce
immunodeficiency,
leading
irreversible
injury
immune
system.
study
emphasizes
benefits
of
thymus.
ameliorate
Cd-triggered
dysfunction
pyroptosis
tissues.
modulated
PI3K/AKT/FOXO1
axis,
improving
level
claudin-5
(CLDN5)
alleviate
breakdown.
findings
indicated
impact
on
thymus,
be
specific
target
toxicity.
finding
also
provides
evidence
role
maintaining
thymic
homeostasis
Cd-related
Язык: Английский