
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Июль 31, 2024
Язык: Английский
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Июль 31, 2024
Язык: Английский
Phytomedicine, Год журнала: 2024, Номер 135, С. 156139 - 156139
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
5Antioxidants, Год журнала: 2025, Номер 14(3), С. 265 - 265
Опубликована: Фев. 25, 2025
Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.
Язык: Английский
Процитировано
0Network Modeling Analysis in Health Informatics and Bioinformatics, Год журнала: 2025, Номер 14(1)
Опубликована: Март 6, 2025
Язык: Английский
Процитировано
0Seminars in Oncology, Год журнала: 2025, Номер 52(2), С. 152333 - 152333
Опубликована: Март 11, 2025
Язык: Английский
Процитировано
0Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Апрель 2, 2025
Язык: Английский
Процитировано
0Frontiers in Endocrinology, Год журнала: 2025, Номер 16
Опубликована: Апрель 25, 2025
Diabetic cardiomyopathy (DCM) is a common and fatal cardiac complication caused by diabetes, with its pathogenesis involving various forms of cell death mitochondrial dysfunction, particularly ferroptosis injury. Recent studies have indicated that damage play crucial roles in the onset progression DCM, though their precise regulatory mechanisms remain unclear. Of particular interest interaction between damage, as well synergistic effects, which are not fully understood. This review summarizes injury DCM explores molecular involved, an emphasis on interplay these two processes. Additionally, article offers overview targeted drugs shown to be effective cellular experiments, animal models, clinical trials, analyzing action potential side effects. The goal provide insights for future drug development applications. Moreover, challenges prospects multi-target combination therapies personalized medicine interventions practice offer strategic guidance comprehensive prevention management DCM.
Язык: Английский
Процитировано
0International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 4188 - 4188
Опубликована: Апрель 28, 2025
Myricetin is a natural flavonoid with powerful antioxidant and anti-inflammatory potential commonly found in vegetables, fruits, nuts, tea. The vital role of this the prevention treatment various diseases evidenced by its ability to reduce inflammation oxidative stress, maintain tissue architecture, modulate cell signaling pathways. Thus, review summarizes recent evidence on myricetin, focusing precisely mechanisms action pathogenesis, including obesity, diabetes mellitus, arthritis, osteoporosis, liver, neuro, cardio, reproductive system-associated pathogenesis. Moreover, it has been revealed that myricetin exhibits anti-microbial properties due obstructive virulence factors, preventing biofilm formation disrupting membrane integrity. Additionally, synergistic other drugs myricetin-based nanoformulations different are properly discussed. This seeks increase understanding myricetin’s pharmacological diseases, principally highlighting effective action. Further wide-ranging research, as well more randomized controlled clinical trial studies, should be executed reconnoiter compound’s therapeutic value, safety, usefulness against human
Язык: Английский
Процитировано
0Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown
Опубликована: Сен. 16, 2024
Язык: Английский
Процитировано
2Cell Death Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Дек. 2, 2024
Язык: Английский
Процитировано
2Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 20, 2024
Язык: Английский
Процитировано
1