Catechin promotes endoplasmic reticulum stress-mediated gastric cancer cell apoptosis via NOX4-induced reactive oxygen species DOI Creative Commons
Jun Jiang, Deming Li, Fan Li

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 31, 2024

Abstract Background Catechin, a polyphenolic compound in various foods and beverages, shows strong anticancer effects against gastric cancer (GC) cells. This study explored the effect of Catechin on GC cell apoptosis endoplasmic reticulum (ER) stress. Methods cells were treated with different catechin concentrations to assess viability, LDH release, invasion, migration, apoptosis, intracellular calcium (Ca²⁺), ER stress markers, reactive oxygen species (ROS). siRNA knockdown targeted GRP78, PERK, CHOP, NOX4 examine their roles catechin-induced apoptosis. Results treatment significantly reduced increased induced dose-dependently. Catechins elevated Ca²⁺ markers. Co-treatment thapsigargin (TG) intensified these effects, implicating Knocking down CHOP mitigated restored viability. Additionally, catechins raised ROS levels, while co-treatment Diphenyleneiodonium (DPI) or N-acetylcysteine (NAC) lowered ROS, damage, countered viability loss upregulated cleaved caspase-3. Conclusion induce through generation. Key mediators include NOX4, suggesting potential therapeutic targets for enhancing efficacy treatment.

Язык: Английский

Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis DOI
Congcong Lu, Zhen Zhang,

Yuhao Fan

и другие.

Phytomedicine, Год журнала: 2024, Номер 135, С. 156139 - 156139

Опубликована: Окт. 9, 2024

Язык: Английский

Процитировано

5
Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases DOI Creative Commons

Rachid Kacemi,

María G. Campos

Antioxidants, Год журнала: 2025, Номер 14(3), С. 265 - 265

Опубликована: Фев. 25, 2025

Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.

Язык: Английский

Процитировано

0
Prognostic value of ferroptosis-related genes and long non-coding RNAs in colorectal cancer: a meta and bioinformatics analysis DOI

Nima Zafari,

Mahla Velayati,

HamidReza Naderi

и другие.

Network Modeling Analysis in Health Informatics and Bioinformatics, Год журнала: 2025, Номер 14(1)

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

0
Plant polyphenols in gastric cancer: Nature's healing touch DOI
Chengu Niu, Jing Zhang, Patrick Okolo

и другие.

Seminars in Oncology, Год журнала: 2025, Номер 52(2), С. 152333 - 152333

Опубликована: Март 11, 2025

Язык: Английский

Процитировано

0
Myricetin induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways DOI

Xiumin Xu,

Hongtao Yu,

Yuesheng Wang

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Abstract Myricetin is a natural flavonol glycoside that widely found in the fruits, bark and leaves of plant. have been reported to possess variety biological activi-ties, such as antioxidant properties, anti-inflammatory effects, antitumor activity. In this study, we demonstrated for hyperoside inhibited prolifer-ation bladder cancer cells vitro vivo. Moreover, could not only induce cell cycle arrest, but also apoptosis cells. Bioinformat-ics analysis showed myricetin may act mainly through EGFR-Ras Fas sig-naling pathways. experiments activated signaling pathways, up-regulated protein levels EGFR, Ras Fas. Then further downstream proteins MAPK Akt. Through interac-tion signaling, it ultimately promotes its anticancer effects on This study suggests be promising therapeutic clinical candidate cancer.

Язык: Английский

Процитировано

0
From bench to bedside: targeting ferroptosis and mitochondrial damage in the treatment of diabetic cardiomyopathy DOI Creative Commons
Bin Liu, Qing Jin, Yi Sun

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Апрель 25, 2025

Diabetic cardiomyopathy (DCM) is a common and fatal cardiac complication caused by diabetes, with its pathogenesis involving various forms of cell death mitochondrial dysfunction, particularly ferroptosis injury. Recent studies have indicated that damage play crucial roles in the onset progression DCM, though their precise regulatory mechanisms remain unclear. Of particular interest interaction between damage, as well synergistic effects, which are not fully understood. This review summarizes injury DCM explores molecular involved, an emphasis on interplay these two processes. Additionally, article offers overview targeted drugs shown to be effective cellular experiments, animal models, clinical trials, analyzing action potential side effects. The goal provide insights for future drug development applications. Moreover, challenges prospects multi-target combination therapies personalized medicine interventions practice offer strategic guidance comprehensive prevention management DCM.

Язык: Английский

Процитировано

0
Unlocking the Pharmacological Potential of Myricetin Against Various Pathogenesis DOI Open Access
Saleh A. Almatroodi, Arshad Husain Rahmani

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 4188 - 4188

Опубликована: Апрель 28, 2025

Myricetin is a natural flavonoid with powerful antioxidant and anti-inflammatory potential commonly found in vegetables, fruits, nuts, tea. The vital role of this the prevention treatment various diseases evidenced by its ability to reduce inflammation oxidative stress, maintain tissue architecture, modulate cell signaling pathways. Thus, review summarizes recent evidence on myricetin, focusing precisely mechanisms action pathogenesis, including obesity, diabetes mellitus, arthritis, osteoporosis, liver, neuro, cardio, reproductive system-associated pathogenesis. Moreover, it has been revealed that myricetin exhibits anti-microbial properties due obstructive virulence factors, preventing biofilm formation disrupting membrane integrity. Additionally, synergistic other drugs myricetin-based nanoformulations different are properly discussed. This seeks increase understanding myricetin’s pharmacological diseases, principally highlighting effective action. Further wide-ranging research, as well more randomized controlled clinical trial studies, should be executed reconnoiter compound’s therapeutic value, safety, usefulness against human

Язык: Английский

Процитировано

0
Helicobacter pylori induces GBA1 demethylation to inhibit ferroptosis in gastric cancer DOI

Chenjie Shen,

Huan Liu, Yuhan Chen

и другие.

Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 16, 2024

Язык: Английский

Процитировано

2
Infection of Helicobacter pylori contributes to the progression of gastric cancer through ferroptosis DOI Creative Commons
Yun Liu,

Renjie Miao,

Jinxuan Xia

и другие.

Cell Death Discovery, Год журнала: 2024, Номер 10(1)

Опубликована: Дек. 2, 2024

Язык: Английский

Процитировано

2
Catechin promotes endoplasmic reticulum stress-mediated gastric cancer cell apoptosis via NOX4-induced reactive oxygen species DOI
Jun Jiang, Deming Li, Fan Li

и другие.

Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

Язык: Английский

Процитировано

1