Synthesis of paeonol hydrazone derivatives and their anti‐oomycete, anti‐fungal, and nematicidal activities
Pest Management Science,
Год журнала:
2024,
Номер
80(11), С. 5746 - 5758
Опубликована: Июль 14, 2024
The
natural
product
paeonol
is
a
rich
and
sustainable
bioresource,
its
derivatives
have
various
unique
biological
efficacy.
As
well
known,
Schiff
bases
are
class
of
organic
compounds
with
wide
range
activities,
including
anti-fungal,
insecticidal,
anti-viral,
nematicidal.
Язык: Английский
3-Furoic Acid from Sea-Derived Aspergillus luchuensis Hy-6 as a Valuable Lead Compound against Plant-Parasitic Nematodes in Cucumber
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
73(6), С. 3468 - 3482
Опубликована: Янв. 31, 2025
Root-knot
nematodes
pose
a
significant
threat
to
crop
growth
and
yield,
thereby
impacting
global
food
security.
Here,
the
sea-derived
Aspergillus
luchuensis
hy-6
was
identified
as
producer
of
3-furoic
acid
by
liquid
chromatography-mass
spectrometry.
Low
doses
acid,
an
acidic
compound
with
strong
nematicidal
activity,
can
reduce
motility,
lifespan,
egg
hatchability
in
dose-dependent
manner.
Additionally,
found
affect
chemotaxis
Meloidogyne
incognita
toward
cucumber
decreasing
root's
attractive
activity
nematodes.
Metabolomic
analyses
indicated
that
functional
abnormalities
lipid
metabolism
may
represent
critical
molecular
mechanism
underlying
severe
metabolic
dysfunction.
Importantly,
enhancement
control
efficacy
achieved
through
simple
structural
modification,
particularly
pent-4-en-1-yl
furan-3-carboxylate
(A1),
which
superior
acid.
These
findings
validated
potential
promising
lead
development
eco-friendly
nematicides.
Язык: Английский
Design, Synthesis, Nematicidal Activity Evaluation, and Mode of Action Study of Novel Trifluorobutene Ester Derivatives as Potential Nematicides
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 23, 2025
Crop
protection
globally
is
under
threat
from
infections
caused
by
plant-parasitic
nematodes
(PPNs).
PPNs
can
wreak
havoc
on
agricultural
production.
However,
only
limited
nematicides
are
currently
available,
and
the
growing
resistance
problem
a
concern;
therefore,
novel
urgently
needed.
Thirty-three
trifluorobutene
ester
derivatives
were
synthesized,
then
their
biological
activity
against
Meloidogyne
incognita
was
tested
in
this
study.
Among
them,
nine
compounds
exhibited
excellent
vitro
bioactivity
M.
incognita;
LC50/72h
values
reached
1.77-3.95
mg/L.
In
addition,
derivative
of
active
compound
above
containing
piperazine
ring
significant
vivo
with
an
inhibition
rate
77.3%
at
1.25
mg/L
matrix.
The
structure-activity
relationships
(SARs)
all
synthesized
analyzed,
further
comparative
molecular
field
analysis
(CoMFA)
calculated
to
discuss
SAR
profile.
preliminary
mechanisms
action
study
suggested
that
some
had
great
inhibitory
effect
egg
hatching,
motility,
feeding
ability,
growth
Caenorhabditis
elegans.
Meanwhile,
effects
biochemical
indices
related
oxidative
stress
indicated
two
could
significantly
promote
induce
toxicity
through
damage.
Язык: Английский
Design, Synthesis, and Acaricidal Activity of 2,5-Diphenyl-1,3-oxazoline Compounds
Molecules,
Год журнала:
2024,
Номер
29(17), С. 4149 - 4149
Опубликована: Авг. 31, 2024
By
using
a
scaffold
hopping/ring
equivalent
and
intermediate
derivatization
strategies,
series
of
compounds
2,5-diphenyl-1,3-oxazoline
with
substituent
changes
at
the
5-phenyl
position
were
prepared,
their
acaricidal
activity
was
studied.
However,
synthesized
2,5-diphenyl-1,3-oxazolines
showed
lower
against
mite
eggs
larvae
compared
to
2,4-diphenyl-1,3-oxazolines
same
substituents.
We
speculate
that
there
is
significant
difference
in
spatial
extension
direction
substituents
between
two
skeletons
compounds,
resulting
differences
ability
bind
potential
target
chitin
synthase
1.
This
work
helpful
inferring
internal
structure
binding
pockets.
Язык: Английский
Direct Reductive N‐Alkylation of Amines with carboxylic Esters
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 29, 2024
Abstract
We
report
herein
a
facile
direct
method
for
the
reductive
N
‐alkylation
of
amines
with
carboxylic
esters,
using
tert
‐butylmagnesium
chloride
(
t
‐BuMgCl)
as
mediator
and
Red‐Al
reducing
agent.
The
amidation
esters
‐BuMgCl
generates
intermediate
amides.
Subsequently,
without
need
isolation
or
purification,
these
intermediates
reacted
in
same
reaction
flask
to
generate
up
90
%
yield.
This
process
is
characterized
by
rapid
time,
quantitative
conversion,
broad
ester
scope
various
functional
groups.
Notably,
this
enables
successful
transformation
amine
produce
cariprazine,
pivotal
antipsychotic
drug
substance.
Язык: Английский