Unveiling the mechanism of Latilactobacillus sakei LZ217 cell-free supernatant against Helicobacter pylori through metabolomics and network pharmacology

Food Bioscience, Год журнала: 2025, Номер unknown, С. 105925 - 105925

Опубликована: Янв. 1, 2025

Язык: Английский

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Coatings Based on Essential Oils for Combating Antibiotic Resistance

Antibiotics, Год журнала: 2024, Номер 13(7), С. 625 - 625

Опубликована: Июль 4, 2024

In the current era of widespread antimicrobial resistance, utilization essential oils (EOs) derived from plants has emerged as a promising alternative in combating pathogens that have developed resistance to antibiotics. This review explores therapeutic potential valuable tools restoring efficacy antibiotics, highlighting their unique ability affect bacteria multiple ways and target various cellular systems. Despite challenge elucidating precise mode action, EOs shown remarkable results rigorous testing against diverse range bacteria. multifaceted role bacterial microorganisms, emphasizing extraction methods, mechanisms comparative synthetic Key findings underscore strategies deploy counter bacteria, significant differences conventional The extends advanced coating solutions for medical devices, exploring integration EO formulations into these coatings. Challenges developing effective coatings are addressed, along with innovative approaches implementation. An evaluation reveals formidable alternatives traditional antibacterial agents device applications. renaissance natural remedies emphasizes need combine wisdom modern scientific advancements address urgent post-antibiotic era.

Язык: Английский

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Amygdalin Alleviates DSS-Induced Colitis by Restricting Cell Death and Inflammatory Response, Maintaining the Intestinal Barrier, and Modulating Intestinal Flora

Cells, Год журнала: 2024, Номер 13(5), С. 444 - 444

Опубликована: Март 3, 2024

Inflammatory bowel disease (IBD) refers to a cluster of intractable gastrointestinal disorders with an undetermined etiology and lack effective therapeutic agents. Amygdalin (Amy) is glycoside extracted from the seeds apricot other Rosaceae plants it exhibits wide range pharmacological properties. Here, effects mechanisms Amy on colitis were examined via 16S rRNA sequencing, ELISA, transmission electron microscopy, Western blot, immunofluorescence. The results showed that administration remarkably attenuated signs (reduced body weight, increased activity index, shortened colon length) histopathological damage in dextran sodium sulfate (DSS)-challenged mice. Further studies revealed significantly diminished DSS-triggered gut barrier dysfunction by lowering pro-inflammatory mediator levels, inhibiting oxidative stress, reducing intestinal epithelial apoptosis ferroptosis. Notably, lowered TLR4 expression phosphorylation proteins related NF-κB MAPK pathways. Furthermore, modulated balance flora, including selective rise abundance S24-7 decline Allobaculum, Oscillospira, Bacteroides, Sutterella, Shigella. In conclusion, can alleviate colitis, which provides data support utility combating IBD.

Язык: Английский

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Characterization of Quality Marker for Mume Fructus Pulp by Ultra‐Performance Liquid Chromatography‐Quadrupole Time‐of‐Flight Mass Spectrometry‐Based Untargeted Metabolomics Combined With Biological Activities

Phytochemical Analysis, Год журнала: 2025, Номер unknown

Опубликована: Янв. 12, 2025

ABSTRACT Introduction As a widely used Chinese herbal medicine, Mume Fructus pulp (MFP) has rich nutritional value and biological activity, but its quality control research is relatively scarce. Objectives The objective of the study was to evaluate difference between MFPs from different origins adulterant apricot (APP), identify potential markers. Methods chemical compositions were identified by untargeted metabolomics analysis based on ultra‐performance liquid chromatography‐quadrupole time‐of‐flight mass spectrometry combined with feature‐based molecular networking. effect test samples gene expression pro‐inflammatory cytokines investigated RT‐qPCR ELISA analyses determine their anti‐inflammatory potential. Antioxidant activity assessed free radical scavenging assay. Subsequently, relationship composition analyzed chemometrics, index MFP preliminarily determined. Based network pharmacology docking, markers possible mechanisms further Results There significant differences in contents flavonoids organic acids, as well antioxidant activities habitats. Its APP not only composition, also had significantly weaker activity. Sixteen compounds positively correlated or effects MFP. Combined citric acid, maleic rutin, quercetin, isoquercetin, spiraeoside, hesperidin Conclusion This showed metabolomic bioactivity assays identification

Язык: Английский

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Advances in plant essential oils and drug delivery systems for skincare

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 17, 2025

Essential oils, often referred to as "liquid gold," are renowned for their broad biological activity. Ancient Egyptians used essential oils' antibacterial and antiseptic effects preserve mummies, ancient Greeks olive oil sun protection, Chinese oils treat wounds. When applied the facial skin, potent anti-inflammatory, antioxidant, pharmacological characteristics provide various benefits, including sunscreen, skin-whitening, anti-aging effects. This paper aims summarize application of plant in skin whitening, antioxidant recent years, deeply analyzes internal relationship between modern drug delivery system, expounds how overcome limitations through specific enhance its activity stability, realize sustained release reduce potential toxicity, also discusses positive on brain function olfactory pathway, emphasizes possible safety risks use oil, puts forward corresponding suggestions use. Using keywords such "essential oils," "antioxidant," "anti-tyrosinase," Antibacterial Effects anti-inflammatory," "anti-anxiety," "drug carrier systems," a comprehensive search was conducted PubMed, CNKI, Baidu, Wanfang databases articles from past 5 years. Further screening performed select studies demonstrating efficacy topical or external application. Various showed strong oxidants, agents, anti-inflammatory skin-whitening agents. Combined with new it not only enhances but reduces inherent defects volatility, irritation, has targeted effect. At same time, integration into care products can make dual functions smell epidermal system nourish repair maximize oil. review delves systems, advocating broader natural resources technology. By strategically utilizing we promote sustainable development global economy. However, extensive clinical trials still required evaluate effectiveness systems.

Язык: Английский

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Flavonoids from Cerasus humilis seed coat alleviate constipation in mice: Role of AQP3/4 and c-Kit/SCF signaling pathways

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106643 - 106643

Опубликована: Апрель 1, 2025

Язык: Английский

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p-Synephrine ameliorates non-alcoholic fatty liver disease by regulating liver-adipose axis via AMPK/NF-kappa B pathway

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119890 - 119890

Опубликована: Апрель 1, 2025

Язык: Английский

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Structure, Anti-Inflammatory and Anti-Bacterial Activities of Novel Pentacyclic Triterpenoids from the Leaves of Pittosporum Elevaticostatum

Опубликована: Янв. 1, 2024

Язык: Английский

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Structure, anti-inflammatory and anti-bacterial activities of novel pentacyclic triterpenoids and other constituents from the leaves of Pittosporum elevaticostatum

Fitoterapia, Год журнала: 2024, Номер 177, С. 106142 - 106142

Опубликована: Июль 26, 2024

Язык: Английский

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