Journal of Pure and Applied Microbiology,
Год журнала:
2024,
Номер
18(2), С. 797 - 807
Опубликована: Май 27, 2024
Tremendous
increase
in
anthropogenic
activities
and
natural
disasters
have
created
long
term
negative
impacts
to
the
crop
productivity
as
well
on
our
ecosystem.
In
debate
regarding
ongoing
ecosystem
fluctuations,
there
is
a
need
explore
an
efficient,
cost-effective,
target-oriented
less
manpower-based
technologies
for
sustainable
development.
Microbial
engineering
provides
better
solution
growth
of
healthy
environment
higher
agricultural
over
existing
methods
resolved
challenges
worldwide
related
development
agriculture
greener
ecosystems.
recent
years,
researchers
are
working
different
advanced
microbial
strategies
such
gene
editing,
CRISPR/Cas9,
RNAi
enhance
potential
microorganisms
towards
plant
degradation
pollutants.
The
present
review
focused
applications
genetically
engineered
inoculants
Environmental Science Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
The
study
applies
machine
learning,
including
supervised
learning
and
association
rule
mining,
to
analyze
nanotoxicity
data.
It
reveals
key
associations
predictive
factors,
supporting
safer
nanomaterial
design
risk
assessment.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(4), С. 425 - 425
Опубликована: Март 27, 2024
Aberrant
epigenetic
modifications
are
fundamental
contributors
to
the
pathogenesis
of
various
cancers.
Consequently,
targeting
these
aberrations
with
small
molecules,
such
as
histone
deacetylase
(HDAC)
inhibitors
and
DNA
methyltransferase
(DNMT)
inhibitors,
presents
a
viable
strategy
for
cancer
therapy.
The
objective
this
study
is
assess
anti-cancer
efficacy
trichostatin
C
(TSC),
an
analogue
A
sourced
from
fermentation
Streptomyces
sp.
CPCC
203909.
Our
investigations
reveal
that
TSC
demonstrates
potent
activity
against
both
human
lung
urothelial
bladder
cell
lines,
IC50
values
in
low
micromolar
range.
Moreover,
induces
apoptosis
mediated
by
caspase
3/7
arrests
cycle
at
G2/M
phase.
When
combined
DNMT
inhibitor
decitabine,
exhibits
synergistic
effect.
Additionally,
protein
analysis
elucidates
significant
reduction
expression
tyrosine
kinase
receptor
Axl.
Notably,
elevated
concentrations
correlate
up-regulation
transcription
factor
forkhead
box
class
O1
(FoxO1)
increased
levels
proapoptotic
proteins
Bim
p21.
In
conclusion,
our
findings
suggest
promising
agent
HDAC
inhibitory
activity.
Furthermore,
results
highlight
potential
utility
combination
treatment.
Crops,
Год журнала:
2024,
Номер
4(2), С. 180 - 194
Опубликована: Май 23, 2024
Genetic
variability
in
rice
breeding
programs
plays
a
very
crucial
role.
It
provides
an
outstanding
pool
of
superior
alleles
governing
better
agronomic
and
quality
characters
through
association
mapping.
For
greater
understanding
population
structure,
the
genetic
relationship
among
different
lines
is
indispensable
prior
to
setting
correlation
dynamic
traits.
In
present
investigation,
diversity
structure
116
accessions
were
studied
understand
relatedness
them
using
64
polymorphic
SSR
markers.
A
genotyping
assessment
based
on
markers
revealed
total
225
alleles,
with
average
PIC
value
0.755.
The
germplasm
classified
into
three
distinct
subgroups
analysis,
utilizing
both
model-
distance-based
approaches.
AMOVA
analysis
showed
that
11%
variation
could
be
attributed
differences
between
groups,
while
remaining
89%
was
likely
due
within
groups.
This
study
suggested
should
considered
establish
marker–trait
associations
for
mapping
when
working
core
collection
lines.
Journal of Pure and Applied Microbiology,
Год журнала:
2024,
Номер
18(2), С. 797 - 807
Опубликована: Май 27, 2024
Tremendous
increase
in
anthropogenic
activities
and
natural
disasters
have
created
long
term
negative
impacts
to
the
crop
productivity
as
well
on
our
ecosystem.
In
debate
regarding
ongoing
ecosystem
fluctuations,
there
is
a
need
explore
an
efficient,
cost-effective,
target-oriented
less
manpower-based
technologies
for
sustainable
development.
Microbial
engineering
provides
better
solution
growth
of
healthy
environment
higher
agricultural
over
existing
methods
resolved
challenges
worldwide
related
development
agriculture
greener
ecosystems.
recent
years,
researchers
are
working
different
advanced
microbial
strategies
such
gene
editing,
CRISPR/Cas9,
RNAi
enhance
potential
microorganisms
towards
plant
degradation
pollutants.
The
present
review
focused
applications
genetically
engineered
inoculants
