Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 9307 - 9317
Опубликована: Ноя. 1, 2024
The
transient
receptor
potential
vanilloid
4
channel
(TRPV4)
is
an
important
member
of
the
TRP
superfamily
cation
channels.
can
be
activated
by
different
physical
and
chemical
stimuli,
such
as
heat,
osmotic,
mechanical
stress.
It
regulates
release
nociceptive
peptides
(substance
P
calcitonin
gene-related
peptide),
mediates
neurogenic
inflammation,
which
indicates
involvement
TRPV4
a
nociceptor.
Previous
studies
show
that
contraction
intestinal
smooth
muscle,
mucosal
barrier
permeability,
ion
transport,
activation
submucosal
enteric
neurons,
generation
immune
cells.
involved
in
various
pathophysiological
activities,
altered
expression
has
been
detected
some
diseases
(IBD,
IBS,
tumors,
etc).
Evidence
plays
noxious
role
function
when
intestine
damaged.
This
review
focuses
on
physiological
pathological
functions
intestine,
evaluates
clinical
significance
to
target
treatment
diseases.
