Review of the Protective Effects of Selenium against T-2 Toxin-Induced Toxicity

Chemical Research in Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Май 21, 2025

The objective of the present study was to review potential protective effects Se against T-2 toxin-induced adverse in cartilage and other tissues as well discuss molecular mechanisms by which counteracts toxicity. Laboratory studies demonstrate that attenuates chondrocyte death inhibition mitochondrial pathway apoptosis. Protective oxidative stress chondrocytes are mediated improvement antioxidant selenoprotein expression, is altered upon mycotoxin exposure. In addition stress, treatment associated with mycotoxin-induced ferroptosis. Along prevention damage, improves extracellular matrix (ECM) metabolism up-regulation type II collagen proteoglycans expression ECM degradation metalloproteinases. It also noteworthy part interactive between toxin exposure epigenetic mechanisms, especially modulation noncoding RNA expression. Recent evidence shows mitigates toxic liver, kidney, immune system, organs. Notably, a number demonstrated deficiency aggravates exposure, supporting notion Se. However, existing data were obtained laboratory vivo vitro models, therapeutic supplementation toxin-exposed human subjects have yet be fully characterized.

Язык: Английский

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The Novel Role of the NLRP3 Inflammasome in Mycotoxin-Induced Toxicological Mechanisms

Veterinary Sciences, Год журнала: 2024, Номер 11(7), С. 291 - 291

Опубликована: Июнь 28, 2024

Mycotoxins are secondary metabolites produced by several fungi and moulds that exert toxicological effects on animals including immunotoxicity, genotoxicity, hepatotoxicity, teratogenicity, neurotoxicity. However, the mechanisms of mycotoxins complex unclear. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin containing 3 (NLRP3) inflammasome is a multimeric cytosolic protein composed NLRP3 sensor, ASC adapter protein, caspase-1 effector. Activation plays crucial role in innate immune defence homeostatic maintenance. Recent studies have revealed activation linked to tissue damage inflammation induced mycotoxin exposure. Thus, this review summarises latest advancements research roles pathogenesis exposure multiple mycotoxins, deoxynivalenol, aflatoxin B1, zearalenone, T-2 toxin, ochratoxin A, fumonisim pyroptosis-related factors inflammation-related vitro vivo pharmacological inhibition specific nonspecific inhibitors summarized examined. This comprehensive contributes better understanding toxicity provides novel insights for pharmacologically targeting as anti-inflammatory agent against

Язык: Английский

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T-2 mycotoxin: From occurrence and toxicokinetics to recent advances in aptasensor-based detection strategies and future perspectives for enhanced food safety

Trends in Food Science & Technology, Год журнала: 2024, Номер unknown, С. 104784 - 104784

Опубликована: Ноя. 1, 2024

Язык: Английский

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The Toxic Effects and Mechanisms of Maternal Exposure to Bisphenol F During Gestation and Lactation on Lungs in Female Offspring Mice

Environmental Pollution, Год журнала: 2024, Номер 361, С. 124800 - 124800

Опубликована: Авг. 22, 2024

Язык: Английский

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New insights into evodiamine attenuates IPEC-J2 cells pyroptosis induced by T-2 toxin - Activating Keap1-Nrf2/NF-κB signaling pathway through binding with Keap1

Journal of Environmental Management, Год журнала: 2024, Номер 370, С. 122605 - 122605

Опубликована: Сен. 21, 2024

Язык: Английский

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Reproductive, gestational, and fetal alterations induced by dietary mycotoxins: A systematic review

Pesquisa Veterinária Brasileira, Год журнала: 2024, Номер 44

Опубликована: Янв. 1, 2024

ABSTRACT: Mycotoxins are low molecular weight secondary metabolites produced by some fungi genera, such as Aspergillus, Penicillium, Alternaria, Fusarium, and Claviceps, during their growth in foods. These molecules share several common characteristics, including toxicity, carcinogenesis, teratogenesis animals humans. This review addresses the reproductive, gestational fetal changes induced ochratoxin A, fumonisins, zearalenone, patulin, deoxynivalenol, T-2 toxin. A systematic evaluation of scientific articles was conducted on research portals PubMed Google Scholar using keywords related to topic. The revealed all characteristics available literature, indicating a growing academic concern deposition information about these mycotoxins.

Язык: Английский

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Combined effects of deltamethrin and T-2 toxin on animals during the use of bentonite

E3S Web of Conferences, Год журнала: 2024, Номер 548, С. 01017 - 01017

Опубликована: Янв. 1, 2024

This study investigated the combined effects of deltamethrin and T-2 toxin on animals, utilizing bentonite as a prophylactic agent. The research was conducted white rats, which were orally administered toxins for 20 consecutive days. Subsequently, clinical, hematological, biochemical parameters examined to assess impact animals. Based results, it has been established that effect with repeated administration is characterized by more severe hematological changes than separate exposure toxicants. Accompanied decrease in number leukocytes, erythrocytes hemoglobin, total protein, glucose cholinesterase activity. Adding feed agent at dose 2% diet preventive case poisoning T- 2 toxin, helps normalize

Язык: Английский

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Metasilicate-based alkaline mineral water improves the growth performance of weaned piglets by maintaining gut-liver axis homeostasis through microbiota-mediated secondary bile acid pathway

Animal nutrition, Год журнала: 2024, Номер 20, С. 95 - 109

Опубликована: Ноя. 2, 2024

Weaning stress causes substantial economic loss in the swine industry. Moreover, weaning-induced intestinal barrier damage and dysfunction of gut-liver axis are associated with reduced growth performance piglets. Metasilicate-based alkaline mineral water (AMW) has shown potential therapeutic effects on gastrointestinal disorders; however, mechanisms involved their overall have not been explored. Here, sodium metasilicate (SMS) was used to prepare metasilicate-based AMW (basal + 500 mg/L SMS). A total 240 newly weaned piglets were allocated Control SMS groups (6 replicate pens per group 20 pen) for a 15-day trial period. Histopathological evaluations conducted using hematoxylin eosin staining. To analyze composition gut microbiota, 16S rRNA PacBio SMRT Gene Full-Length Sequencing performed. Western blotting immunofluorescence employed assess protein expression levels. Our results indicated that effectively alleviated colonic or liver morphological injury inflammatory response, as well cholesterol metabolism disorders. Further analysis showed promoted deoxycholic acid (DCA) biosynthesis by increasing abundance Lactobacillus_delbrueckii colon (P < 0.001). This consequently improved through DCA-secondary bile (SBA) receptors (SBAR)-nuclear factor-kappaB (NF-κB)/NOD-like receptor family pyrin domain-containing 3 (NLRP3) pathways. Growth parameters, including final body weight = 0.034) average daily gain 0.001), significantly higher than those group. Therefore, maintains homeostasis regulating microbiota-mediated SBA-SBAR pathway under weaning stress. research provides new strategy mitigating stress-induced

Язык: Английский

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Role and mechanism of the outer membrane porin LamB in T-2 mycotoxin-mediated extensive drug resistance in Escherichia coli

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136437 - 136437

Опубликована: Ноя. 6, 2024

Язык: Английский

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