Food & Function, Год журнала: 2024, Номер unknown
Опубликована: Дек. 17, 2024
Astaxanthin affects tryptophan metabolism by regulating intestinal flora.
Язык: Английский
Cancer Letters, Год журнала: 2025, Номер unknown, С. 217459 - 217459
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Analytical Methods, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Saponins are responsible for the clinical effects of Panax notoginseng leaves, which traditionally produced as single herb resource ‘Qiye Shenan Pian’ in Chinese patent medicine.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Март 25, 2025
Gut homeostasis is critical for human health, ulcerative colitis (UC) can disrupt gut and cause disease. Panax ginseng C.A. Meyer a widely used traditional herbal medicine known its anti-inflammatory, antioxidant, immunomodulatory effects. However, the protective mechanisms of total ginsenosides (TG) in treating UC remain unclear. In this study, we employed Drosophila melanogaster as model organism to investigate effects TG on dextran sulfate sodium (DSS)-induced intestinal injury. Our data showed that significantly improved survival rates female flies, restored length, maintained barrier integrity, alleviated oxidative stress. Additionally, may protect against damage by activating PI3K/Akt signaling pathway inhibiting JAK/STAT pathway. These findings suggest alleviates symptoms through multi-target regulation, highlighting potential developing novel therapeutic strategies UC.
Язык: Английский
Процитировано
0
Journal of Functional Foods, Год журнала: 2025, Номер 127, С. 106770 - 106770
Опубликована: Март 29, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134860 - 134860
Опубликована: Авг. 18, 2024
Язык: Английский
Процитировано
3
Food & Function, Год журнала: 2024, Номер 15(18), С. 9037 - 9052
Опубликована: Янв. 1, 2024
The occurrence and progression of mild cognitive impairment (MCI) are closely related to dysbiosis the gut microbiota. Ginsenoside compound K (CK), a bioactive component ginseng, has been shown alleviate microbiota neural damage. However, mechanisms by which CK regulates improve MCI remain unexplored. In this study, an mouse model induced D-galactose was used, 16S rRNA gene sequencing, metabolomics, transcriptomics, integrative multi-omics analyses were employed investigate potential alleviates through modulation results demonstrated that repaired intestinal barrier dysfunction caused MCI, improved blood-brain (BBB) integrity, inhibited activation microglial cells astrocytes, significantly ameliorated MCI. Furthermore, enhanced diversity, notably enriched beneficial bacteria such as
Язык: Английский
Процитировано
2
J — Multidisciplinary Scientific Journal, Год журнала: 2024, Номер 7(3), С. 351 - 372
Опубликована: Сен. 4, 2024
The discovery of natural products has been pivotal in drug development, providing a vast reservoir bioactive compounds from various biological sources. This narrative review addresses critical research gap: the largely underexplored role gut microbiota mediation and biotransformation medicinal herb-derived for therapeutic use. By examining interplay between products, this highlights potential microbiota-mediated to unveil novel agents. It delves into mechanisms by which microbes modify enhance efficacy with focus on herbal medicines Ayurveda traditional Chinese medicine, known their applications treating metabolic inflammatory diseases. also discusses recent advances microbiota-derived product research, including innovative methodologies such as culturomics, metagenomics, metabolomics. exploring intricate interactions microorganisms substrates, uncovers new strategies leveraging processes development groundbreaking therapeutics.
Язык: Английский
Процитировано
2
Foods, Год журнала: 2024, Номер 13(17), С. 2843 - 2843
Опубликована: Сен. 7, 2024
Yellow tea (YT), a slightly fermented with unique yellowing process and mellow taste, is becoming widely popular. Currently, the YT includes bud yellow (BYT), small-leaf (SYT), large-leaf (LYT) based on maturity of raw materials. Previous studies have shown that has outstanding potential in preventing metabolic syndrome. However, distinct effects mechanisms different types ulcerative colitis (UC) are still unclear. This study investigated continuous or intermittent intervention three water extracts (YTEs) dextran sulfate sodium (DSS)-induced CD-1 mice. The results showed YTE significantly improves syndrome DSS-induced UC Mechanistic reveal YTEs increase expression levels tight junction (TJ) proteins reduce pro-inflammatory cytokines colon by inactivating TLR4/NF-κB/NLRP3. treatment protected intestinal barrier integrity reduced serum lipopolysaccharide (LPS) levels. Interestingly, our indicate better alleviating effect than BYT SYT. before DSS administration certain degree preventive colitis, while after induction significant reversing damage caused DSS. Our indicated drinking may therapeutic UC, especially LYT.
Язык: Английский
Процитировано
1
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 15(1), С. 508 - 525
Опубликована: Окт. 23, 2024
The aryl hydrocarbon receptor (AhR) plays a crucial role in regulating many physiological processes. Activating the AhR-CYP1A1 axis has emerged as novel therapeutic strategy against various inflammatory diseases. Here, practical situ cell-based fluorometric assay was constructed to screen modulators, via functional sensing of CYP1A1 activities live cells. Firstly, cell-permeable, isoform-specific enzyme-activable fluorogenic substrate for rationally in-situ visualizing dynamic changes function living systems, which subsequently used discovering efficacious modulators axis. Following screening compound library, LAC-7 identified an activator axis, dose-dependently up-regulated expression levels both and AhR multiple cell lines. also suppressed macrophage M1 polarization reduced factors LPS-induced bone marrow-derived macrophages. Animal tests showed that could significantly mitigate DSS-induced ulcerative colitis acute lung injury mice, markedly factors. Collectively, optimized devised imaging strongly facilitated discovery anti-inflammatory agents.
Язык: Английский
Процитировано
1
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(44), С. 24387 - 24399
Опубликована: Окт. 22, 2024
The cornea serves as a vital protective shield for the eye, safeguarding its intricate internal structures from external threats. Damage to compromises this function, triggering inflammation and potentially causing long-term harm. While ginsenoside Rk3 has demonstrated potential repairing corneal barrier reducing inflammation, effectiveness in treating damage remains relatively unexplored. This comprehensive study uses both vivo vitro models investigate therapeutic capabilities of Rk3. Using two damage, benzalkonium chloride-induced mouse model high osmolarity-induced human epithelial cell model, we scrutinized effects treatment. Our results showed that Rk3-treated mice manifested reduced compared with their untreated counterparts. Furthermore, treated exhibited an organized arrangement cells diminished stromal layer thickness, indicating reparative properties Additionally, increased expression tight junction proteins, suppressed inflammatory factors, decreased HMGB1 protein expression, thereby modulating downstream signaling pathways. Collectively, our findings present compelling evidence is promising option injury. By barrier, mitigating specific levels, opens new avenues managing damage.
Язык: Английский
Процитировано
1