Plant polyphenols as natural bioactives for alleviating lipid metabolism disorder: Mechanisms and application challenges

Food Research International, Год журнала: 2025, Номер 203, С. 115682 - 115682

Опубликована: Янв. 16, 2025

Язык: Английский

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Targeting Ferroptosis as an Advance Strategy in Cancer Therapy

Antioxidants and Redox Signaling, Год журнала: 2024, Номер 41(10-12), С. 616 - 636

Опубликована: Июль 3, 2024

This study innovates by systematically integrating the molecular mechanisms of iron death and its application in cancer therapy. By deeply analyzing interaction between tumor microenvironment, provides a new theoretical basis for treatment directions developing more effective strategies. In addition, points to critical issues barriers that need be addressed future research, providing valuable insights into use clinical translation.

Язык: Английский

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Identification of Penexanthone A as a Novel Chemosensitizer to Induce Ferroptosis by Targeting Nrf2 in Human Colorectal Cancer Cells

Marine Drugs, Год журнала: 2024, Номер 22(8), С. 357 - 357

Опубликована: Авг. 6, 2024

Ferroptosis has emerged as a potential mechanism for enhancing the efficacy of chemotherapy in cancer treatment. By suppressing nuclear factor erythroid 2-related 2 (Nrf2), cells may lose their ability to counteract oxidative stress induced by chemotherapy, thereby becoming more susceptible ferroptosis. In this study, we investigate penexanthone A (PXA), xanthone dimer component derived from endophytic fungus

Язык: Английский

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Photocatalytic degradation of the pesticide pyridaben: Identification of degradation pathways using SERS and GC–MS

Food Research International, Год журнала: 2025, Номер 202, С. 115738 - 115738

Опубликована: Янв. 13, 2025

Язык: Английский

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Plant polyphenols in gastric cancer: Nature's healing touch

Seminars in Oncology, Год журнала: 2025, Номер 52(2), С. 152333 - 152333

Опубликована: Март 11, 2025

Язык: Английский

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Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular Functions

Stresses, Год журнала: 2025, Номер 5(2), С. 26 - 26

Опубликована: Апрель 4, 2025

Cellular stressors have been demonstrated to exert a substantial influence on the functionality of organelles, thereby impacting cellular homeostasis and contributing development disease pathogenesis. This review aims examine impact diverse stressors, including environmental, chemical, biological, physical factors, critical organelles such as cell membrane, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, membrane-less organelles. The intricate molecular mechanisms underlying stress responses, encompassing oxidative stress, protein misfolding, metabolic reprogramming, capacity elicit adaptive responses or culminate in pathological conditions. interplay between these organelle dysfunction has implicated myriad diseases, neurodegenerative disorders, cancer, immune-related pathologies. A comprehensive understanding by which respond can offer valuable insights into therapeutic strategies aimed at mitigating damage.

Язык: Английский

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Effects of Ocean Acidification on Intestinal Homeostasis and Organismal Performance in a Marine Bivalve: From Microbial Shifts to Physiological Suppression

Опубликована: Янв. 1, 2025

Язык: Английский

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Cerebroprotein hydrolysate-I ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via the p53/SAT1/ALOX15 signalling pathway

European Journal of Pharmacology, Год журнала: 2024, Номер 979, С. 176820 - 176820

Опубликована: Июль 18, 2024

Ferroptosis, an iron-dependent lipid peroxidation-driven cell death pathway, has been linked to the development of Alzheimer's disease (AD). However, role ferroptosis in pathogenesis AD remains unclear. Cerebroprotein hydrolysate-I (CH–I) is a mixture peptides with neurotrophic effects that improves cognitive deficits and reduces amyloid burden. The present study investigated ferroptosis-induced signalling pathways neuroprotective CH–I brains transgenic mice. Seven-month-old male APPswe/PS1dE9 (APP/PS1) mice were treated intraperitoneal injections saline for 28 days. Morris water maze test was used assess function. significantly improved attenuated beta-amyloid (Aβ) aggregation tau phosphorylation hippocampus APP/PS1 RNA sequencing revealed multiple genes pathways, including ferroptosis-related involved CH–I. increased levels peroxidation, ferrous ions, reactive oxygen species (ROS), altered expression (recombinant solute carrier family 7, member 11 (SLC7A11), spermidine/spermine N1-acetyltransferase 1 (SAT1) glutathione peroxidase 4 (GPX4)) alleviated after treatment. Quantitative real-time PCR western blotting performed investigate key p53/SAT1/arachidonic acid 15-lipoxygenase (ALOX15) pathway. p53/SAT1/ALOX15 pathway found be mediating ferroptosis, activation this suppressed by demonstrated against attenuating thus providing new targets

Язык: Английский

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Alleviates Effects of γ-cyclodextrin/Genistein Inclusion Complex on Oxidative Stress Injury Induced by Organic Hydrogen Peroxide in PC12 Cells via Nrf2/GPx4 Signaling Pathway

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105631 - 105631

Опубликована: Дек. 1, 2024

Язык: Английский

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Traditionally used edible medicinal plants protect against rotenone induced toxicity in SH-SY5Y cells- a prospect for the development of herbal nutraceuticals.

Neurochemistry International, Год журнала: 2024, Номер 180, С. 105855 - 105855

Опубликована: Сен. 6, 2024

Язык: Английский

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