Novel Diphenyl Ether Carbonyl Ester Fragment as a Promising Skeleton Targeting Succinate Dehydrogenase DOI
Yanhao Hu,

Z. XIONG,

Mian Wei

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Succinate dehydrogenase (SDH) is a globally recognized critical target for fungicides. Our research mainly focuses on discovering novel molecular skeletons targeting SDH. We designed series of diphenyl ether ester derivatives that exhibit potential efficacy against Rhizoctonia solani by utilizing bioisosteric approach. These results indicate compounds with shorter linkers significantly enhance the antifungal activity. Furthermore, an ester-linked compound was superior to its amide and N-(alkoxy) counterparts. Specifically, ba achieved remarkable 92% in controlling R. at dosage 50 μg/mL EC50 value 0.44 μg/mL, thus outperforming boscalid without negatively impacting rice growth. Moreover, caused significant damage mycelium demonstrated IC50 1.69 μM SDH, exhibiting comparable boscalid. unveil promising avenue replacing traditional heterocyclic amide-based inhibitors, potentially heralding new generation SDH-targeting

Язык: Английский

Novel Diphenyl Ether Carbonyl Ester Fragment as a Promising Skeleton Targeting Succinate Dehydrogenase DOI
Yanhao Hu,

Z. XIONG,

Mian Wei

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Succinate dehydrogenase (SDH) is a globally recognized critical target for fungicides. Our research mainly focuses on discovering novel molecular skeletons targeting SDH. We designed series of diphenyl ether ester derivatives that exhibit potential efficacy against Rhizoctonia solani by utilizing bioisosteric approach. These results indicate compounds with shorter linkers significantly enhance the antifungal activity. Furthermore, an ester-linked compound was superior to its amide and N-(alkoxy) counterparts. Specifically, ba achieved remarkable 92% in controlling R. at dosage 50 μg/mL EC50 value 0.44 μg/mL, thus outperforming boscalid without negatively impacting rice growth. Moreover, caused significant damage mycelium demonstrated IC50 1.69 μM SDH, exhibiting comparable boscalid. unveil promising avenue replacing traditional heterocyclic amide-based inhibitors, potentially heralding new generation SDH-targeting

Язык: Английский

Процитировано

0