Targeting tubulin protein to combat fungal disease: Design, synthesis, and its new mechanistic insights of benzimidazole hydrazone derivatives

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140226 - 140226

Опубликована: Янв. 1, 2025

Язык: Английский

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Renewable Resources Derived Glycolipids as a Structuring Agent: A Promising Platform Chemical for Oleogel and Organogel Formation

ACS Food Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

The demand for safe, edible structuring agents across industries such as food, cosmetics, agriculture, pharmaceuticals, and biotechnology has intensified over recent decades. In particular, there is a pressing need to replace trans saturated fatty acids, known contributors cardiovascular other health issues, with healthier alternatives. This study introduces new class of glycolipid-based synthesized from monosaccharides ricinoleic acid, both classified Generally Recognized Safe (GRAS). straightforward synthesis method yields compounds capable self-assembling in various vegetable oils solvents, glycerol, ethylene glycol, poly(ethylene glycol), forming stable oleogels organogels via diverse intermolecular interactions. Morphological investigations using optical microscopy field emission scanning electron (FE-SEM) reveal globular microarchitecture within these molecular gels, 75–150 nm diameters. Rheological analyses confirm the gels' viscoelasticity, thermal processability, thixotropic behavior, supporting their adaptability formulations. These findings underscore potential self-assembled glycolipids 5a 5d, which form versatile, health-conscious significant applications food technology.

Язык: Английский

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Preparation, Antifungal Activity Evaluation, and Mechanistic Studies of Unique and Structurally Novel Pyrazole-Heterocyclic-Amide Analogues

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Thirty-six novel pyrazole-heterocyclic-amide analogues were designed, synthesized, and characterized. The bioassay results showed that most target compounds exhibited good fungicidal activities against Rhizoctonia solani, Gibberella zeae, Pseudoperonospora cubensis, Helminthosporium maydis, Coniothyrium diplodiella at 20 μg/mL. Compounds 6d, 6f, 6l, 6j possessed better than the commercial fungicide prochloraz H. maydis. Their half maximal effective concentration (EC50) values 0.47, 0.26, 0.58, 0.69 μg/mL, respectively, EC50 value of was 0.77 Furthermore, inhibitory for bioactive determined sterol 14α-demethylase (CYP51), displayed they had prominent activities, also CYP51, their (IC50) 0.543, 0.29, 0.77, 0.66, 0.86 respectively. molecular dynamics simulations compound 6f stronger affinity to CYP51 prochloraz, estimated ΔGbind -44.9 -37.2 kcal/mol found

Язык: Английский

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Discovery of Novel Pyrazole/Thiazole Derivatives Containing Cyano/Thiocyanato Groups as Fungicide Candidates

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

The introduction of groups with high drug activity is an effective strategy for discovering novel succinate dehydrogenase inhibitor (SDHI) fungicides, providing insights the future design SDHI fungicides higher efficacy and resistance. In this study, we designed synthesized a series pyrazole/thiazole derivatives containing cyano/thiocyanato evaluated them antifungal activity. Some compounds exhibited promising activities against tested fungi, among them, B31 B35 displayed excellent in vitro Rhizoctonia solani EC50 values 1.83 1.08 μg/mL, which were close proximity to commercial fungicide boscalid (EC50 = 0.87 μg/mL). For Altemaria solani, compound (11.14 μg/mL) showed good below (15.31 SAR studies further reveal that induced conjugated interactions between target receptor facilitate electron transport process, contributing its preliminary mechanistic studies, mycelium cells irregular abnormal state under SEM TEM observation caused production accumulation ROS. Molecular docking results SDH enzyme assays indicate has potential be fungicide.

Язык: Английский

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Fabrication of an antibacterial polybenzimidazole/Ag@UiO-66-NH2 mixed matrix membrane for dye-salt separation: Solvent evaporation effects

Journal of Water Process Engineering, Год журнала: 2024, Номер 68, С. 106491 - 106491

Опубликована: Ноя. 6, 2024

Язык: Английский

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Tunable base-controlled chemoselective synthesis of trifluoromethyl-containing N-substituted benzimidazole-2-thiones and monofluorinated 4H-benzo[4,5]imidazo[2,1-b][1,3]thiazine

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

A base-controlled synthesis of N -β-CF 3 -substituted 2 H -benzo[ d ]imidazole-2-thiones and 2-fluoro-4 -benzo[4,5]imidazo[2,1- b ][1,3]thiazines via hydroamination or defluorinative cyclizations α-CF -styrenes with 2-mercaptobenzimidazole was developed.

Язык: Английский

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