Z‐Astaxanthin exhibits superior anti‐obesity effects in Caenorhabditis elegans: insights from geometric isomers and signaling pathways DOI Open Access

Junting Xie,

Rui Cai,

Xiaoning Hou

и другие.

Journal of the Science of Food and Agriculture, Год журнала: 2025, Номер unknown

Опубликована: Март 9, 2025

Abstract Background Astaxanthin (AST) exists as an ‘all‐ E ’ isomer and various ‘ Z isomers due to its multiple conjugated double bonds. The configuration has been reported exhibit stronger antioxidant activity, raising interest in potential health benefits. All‐ AST is a potent chemopreventive agent for weight loss but the anti‐obesity efficacy of remains unclear. This study therefore explored role geometric (all‐ , 9‐ 13‐ ) on alleviation obesity using Caenorhabditis elegans well established model organism. Results reduced high‐fat worms substantially. Triglyceride (TG) decreased by 18.84%, with all‐ AST, 41.18%, 35.94% ( P < 0.05), indicating that displayed superior effect. Interestingly, particularly ‐isomers, large lipid droplets (LDs) oleic acid/stearic acid (C18:1Δ9/C18:0) significantly; these contribute accumulation. also minimized food intake boosted energy consumption, ‐isomers outperformed enhancing mobility. Using quantitative polymerase chain reaction (qPCR), green fluorescent protein binding, gene‐deficient nematodes, findings current indicated especially isomers, suppressed key gene expression sbp‐1 / mdt‐15 insulin/insulin‐like growth factor signaling (IIS) pathways, which are responsible regulating fatty composition balance, subsequently co‐downregulated essential genes fat‐6 fat‐7 involved C18:1 Δ 9 synthesis. Conclusion provides important insights into association between effects carotenoids, guiding their application field. © 2025 Society Chemical Industry.

Язык: Английский

Z‐Astaxanthin exhibits superior anti‐obesity effects in Caenorhabditis elegans: insights from geometric isomers and signaling pathways DOI Open Access

Junting Xie,

Rui Cai,

Xiaoning Hou

и другие.

Journal of the Science of Food and Agriculture, Год журнала: 2025, Номер unknown

Опубликована: Март 9, 2025

Abstract Background Astaxanthin (AST) exists as an ‘all‐ E ’ isomer and various ‘ Z isomers due to its multiple conjugated double bonds. The configuration has been reported exhibit stronger antioxidant activity, raising interest in potential health benefits. All‐ AST is a potent chemopreventive agent for weight loss but the anti‐obesity efficacy of remains unclear. This study therefore explored role geometric (all‐ , 9‐ 13‐ ) on alleviation obesity using Caenorhabditis elegans well established model organism. Results reduced high‐fat worms substantially. Triglyceride (TG) decreased by 18.84%, with all‐ AST, 41.18%, 35.94% ( P < 0.05), indicating that displayed superior effect. Interestingly, particularly ‐isomers, large lipid droplets (LDs) oleic acid/stearic acid (C18:1Δ9/C18:0) significantly; these contribute accumulation. also minimized food intake boosted energy consumption, ‐isomers outperformed enhancing mobility. Using quantitative polymerase chain reaction (qPCR), green fluorescent protein binding, gene‐deficient nematodes, findings current indicated especially isomers, suppressed key gene expression sbp‐1 / mdt‐15 insulin/insulin‐like growth factor signaling (IIS) pathways, which are responsible regulating fatty composition balance, subsequently co‐downregulated essential genes fat‐6 fat‐7 involved C18:1 Δ 9 synthesis. Conclusion provides important insights into association between effects carotenoids, guiding their application field. © 2025 Society Chemical Industry.

Язык: Английский

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