Titanium dioxide-induced fibrotic liver model and the therapeutic effect of resveratrol by modulation of α-SMA and 8-oHdG expressions, oxidative stress, and inflammation
Tissue and Cell,
Год журнала:
2025,
Номер
93, С. 102748 - 102748
Опубликована: Янв. 18, 2025
Язык: Английский
Resveratrol Alleviates Liver Fibrosis by Targeting Cross‐Talk Between TLR2/MyD88/ERK and NF‐κB/NLRP3 Inflammasome Pathways in Macrophages
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2025,
Номер
39(3)
Опубликована: Март 1, 2025
ABSTRACT
Resveratrol
alleviates
liver
fibrosis
in
mice
by
upregulating
IL‐10
to
reprogram
the
macrophage
phenotype;
however,
mechanism
remains
be
elucidated.
Building
on
our
previous
work,
this
study,
we
aimed
determine
role
of
TLR2/MyD88/ERK
and
NF‐κB/NLRP3
inflammasome
pathways
mediating
effects
resveratrol
polarization.
We
investigated
expression
cytokines
these
a
mouse
model
resveratrol‐treated
macrophages.
The
results
showed
that
TLR2,
MyD88,
ERK,
NF‐κB1
tissues
was
increased
fourth
week
after
treatment
with
but
decreased
fifth
week.
Similar
were
obtained
for
pathway.
also
both
macrophages
elevated
24
h
reduced
36
resveratrol.
Immunofluorescence
nucleocytoplasmic
separation
assays
inhibited
translocation
NF‐κB
from
cytoplasm
nucleus
macrophages,
associated
inhibition
Silencing
ERK.
In
conclusion,
are
involved
effect
polarization
subsequent
modulation
fibrosis.
acts
as
common
cytokine
coordinates
crosstalk
between
two
pathways.
Our
findings
highlight
potential
members
therapeutic
targets
toward
Язык: Английский
Potential protective role of Lycium ruthenicum Murray polysaccharides against lipopolysaccharide-induced liver injury via mitochondrial biogenesis
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 141365 - 141365
Опубликована: Фев. 1, 2025
Язык: Английский
Albiflorin inhibits inflammation to improve liver fibrosis by targeting the CXCL12/CXCR4 axis in mice
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 30, 2025
Liver
fibrosis
is
a
common
pathological
feature
of
chronic
hepatic
injury
that
currently
lacks
effective
therapeutic
interventions.
Albiflorin
(ALB),
pinane-type
monoterpene
derived
from
Paeonia
lactiflora
Pall,
has
notable
anti-inflammatory
and
hepatoprotective
effects.
However,
the
potential
role
ALB
against
liver
largely
unknown.
In
this
study,
we
discovered
significantly
inhibited
CCl4-induced
in
mice.
This
was
evidenced
by
improvements
kidney
function
indexes,
indicators,
histopathological
findings.
vitro
studies
also
showed
TGF-β1-induced
LX-2
cell
activation
reduced
expression
α-SMA
collagen
I.
Additionally,
found
mitigates
inflammation
ameliorates
targeting
CXCL12/CXCR4
axis,
as
confirmed
using
CXCR4
inhibitor
AMD3100
CCl4-treated
Notably,
combining
with
metformin
(MET)
enhanced
inhibition
progression.
These
findings
highlight
exerts
anti-liver
effects
underscoring
its
standalone
treatment
or
an
adjuvant
therapy.
Язык: Английский
The NRF2 Response to Environmental Stress
Elsevier eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Effects of Resveratrol on Intestinal Flora and Metabolism in Rats With Non‐Steroidal Anti‐Inflammatory Drug‐Induced Intestinal Injury Under Plateau Hypoxia Environment
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(5)
Опубликована: Май 1, 2025
ABSTRACT
The
plateau
hypoxic
environment
is
a
main
habitat
for
human
beings,
which
can
result
in
dysbiosis
of
the
intestinal
flora.
Non‐steroidal
anti‐inflammatory
drugs
(NSAIDs)
are
widely
used
that
cause
damage
with
long‐term
administration.
Moreover,
administration
these
may
exacerbate
damage.
This
study
aimed
to
investigate
therapeutic
effect
resveratrol
(RSV)
on
injury
induced
by
NSAIDs
rats
under
hypoxia.
Aspirin
was
as
inducer
induce
rats.
Rats
were
divided
into
seven
groups:
Ck
(vehicle
group),
HCk
(high‐altitude
control
PAsp
(plain
aspirin‐treated
HAsp
(High‐altitude
RSVL
(low‐dose
resveratrol‐treated
RSVM
(medium‐dose
and
RSVH
(high‐dose
group).
body
weight
recorded
every
7
days
during
experiment.
On
last
day
experiment,
jejunal
tissues
collected
hematoxylin
eosin
staining
(H&E),
feces
analysis
flora
metabolite
analysis.
results
demonstrated
RSV
inhibited
loss
initiated
aspirin
environment.
it
markedly
elevated
expression
levels
interleukin
(IL)‐10
superoxide
dismutase
(SOD)
while
substantially
reducing
TNF‐α,
IL‐1β,
myeloperoxidase
(MPO).
Furthermore,
16SrRNA
gene
sequence
showed
both
altered
composition
structure
rat
gut
microbiomes.
Metabolomics
metabolites
aspirin‐induced
rats,
content
2‐hydroxy‐3‐
(4‐hydroxyphenyl)
protonic
acid
3‐
[(1‐carboxyvinyl)
oxy]
benzoate
increasing
coumaryl,
3‐amino‐4
hydroxybenzoate,
L‐carnitine.
Resveratrol
alleviate
NSAID
(Aspirin)‐induced
regulating
metabolites,
best
group
(50
mg/kg).
Язык: Английский
The role of plant-based dietary compounds in gut microbiota modulation in inflammatory bowel disease
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Май 30, 2025
IBD,
which
includes
Crohn’s
and
ulcerative
colitis,
is
associated
with
gut
microbiota
dysbiosis.
The
dysbiotic
environment
results
in
an
elevation
of
harmful
a
diminution
advantageous
microbiota,
leading
to
IBD.
Interestingly,
plant-based
dietary
compounds
consisting
fibers
polyphenols
have
demonstrated
promise
be
safe
successful
IBD
treatment,
studies
revealing
that
they
can
improve
dysbiosis,
increase
anti-inflammatory
cytokines,
decrease
pro-inflammatory
lower
oxidative
stress,
barrier
function.
Plant-based
shown
potential
reduce
by
regulating
signaling
pathways
such
as
TGF-β/Smad,
TRL-4/NF-κB/MAPK,
TLR2-NF-κB,
autophagy,
pyroptosis,
glycolysis/gluconeogenesis
amino
acid
metabolism,
Nrf-2/HO-1,
microbiota-macrophage-arginine
bile
metabolism.
Additionally,
assist
forming
short-chain
fatty
acids
other
metabolites,
help
regulate
immune
cells
alleviate
Recent
research
indicates
compounds,
either
nanoparticles
or
encapsulated
nanoparticles,
effectively
treating
Despite
the
beneficial
role
detrimental
effects
cancer
promotion
exacerbation
responses.
Therefore,
this
will
clinicians/individuals
plan
their
nutrition
prevent
exacerbation.
This
review
highlights
signatures
linked
examines
impact
dysbiosis
on
It
also
provides
comprehensive
discussion
how
influence
modulation
hold
for
Язык: Английский
Advancements in Plant-Based Therapeutics for Hepatic Fibrosis: Molecular Mechanisms and Nanoparticulate Drug Delivery Systems
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9346 - 9346
Опубликована: Авг. 28, 2024
Chronic
liver
injuries
often
lead
to
hepatic
fibrosis,
a
condition
characterized
by
excessive
extracellular
matrix
accumulation
and
abnormal
connective
tissue
hyperplasia.
Without
effective
treatment,
fibrosis
can
progress
cirrhosis
or
hepatocellular
carcinoma.
Current
treatments,
including
transplantation,
are
limited
donor
shortages
high
costs.
As
such,
there
is
an
urgent
need
for
therapeutic
strategies.
This
review
focuses
on
the
potential
of
plant-based
therapeutics,
particularly
polyphenols,
phenolic
acids,
flavonoids,
in
treating
fibrosis.
These
compounds
have
demonstrated
anti-fibrotic
activities
through
various
signaling
pathways,
TGF-β/Smad,
AMPK/mTOR,
Wnt/β-catenin,
NF-κB,
PI3K/AKT/mTOR,
hedgehog
pathways.
Additionally,
this
highlights
advancements
nanoparticulate
drug
delivery
systems
that
enhance
pharmacokinetics,
bioavailability,
efficacy
these
bioactive
compounds.
Methodologically,
synthesizes
findings
from
recent
studies,
providing
comprehensive
analysis
mechanisms
benefits
treatments.
The
integration
novel
with
therapeutics
holds
significant
promise
developing
treatments
Язык: Английский
Immune, Oxidative, and Morphological Changes in the Livers of Tibetan Sheep after Feeding Resveratrol and β-Hydroxy-β-methyl Butyric Acid: A Transcriptome–Metabolome Integrative Analysis
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9865 - 9865
Опубликована: Сен. 12, 2024
This
study
investigated
the
effects
of
dietary
resveratrol
(RES)
and
β-Hydroxy-β-methyl
butyric
acid
(HMB)
on
immune,
oxidative,
morphological
changes
in
livers
Tibetan
sheep
using
transcriptomics
metabolomics.
One
hundred
twenty
male
lambs
a
similar
initial
weight
(15.5
±
0.14
kg)
were
randomly
divided
into
four
groups
with
thirty
per
treatment:
(1)
H
group
(basal
diet
without
RES
or
HMB);
(2)
H-RES
(1.5
g/day
RES);
(3)
H-HMB
(1250
mg/day
(4)
H-RES-HMB
1250
HMB).
The
experiment
was
conducted
for
100
days,
including
pre-test
period
10
days
formal
90
days.
results
showed
significantly
increased
concentrations
glutathione
peroxidase,
superoxide
dismutase,
IgM
(p
<
0.05),
while
malondialdehyde
levels
decreased
0.05).
glycolytic
indices
creatinine
kinase
(CK),
malate
dehydrogenase
(MDH),
succinate
(SDH)
compared
others
A
histological
analysis
that
hepatic
plate
tissue
appeared
normal
multiple
cells.
transcriptomic
expression
genes
associated
calcium
signaling
pathway
(MYLK2,
CYSLTR2,
ADCY1,
HRH1,
ATP2B2,
NOS2,
HRC,
ITPR1,
CAMK2B)
NF-κB
(BCL2
CARD14)
upregulated.
key
differential
metabolites
(d-pyroglutamic
acid,
DL-serine,
DL-threonine,
fumarate,
glyceric
acid)
enriched
pathways
D-amino
metabolism,
citrate
cycle
(TCA
cycle),
carbon
metabolism.
combined
non-targeted
metabolomic
analyses
co-enrichment
(NOS2
GLUD1)
(fumarate)
arginine
biosynthesis-regulated
activity,
whereas
(ME1,
SCD5,
FABP2,
RXRG,
CPT1B)
(Leukotriene
b4)
co-enriched
PPAR
affected
immune
response
by
regulating
PI3K/AKT
cGMP/PKG
signaling.
In
conclusion,
HMB
antioxidant
capacity,
response,
activity
through
modulating
transcriptome
(BCL2,
CAMK2B,
IL1R1)
metabolome
(DL-serine,
fumaric
glycolic
acid).
Язык: Английский
Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11003 - 11003
Опубликована: Окт. 13, 2024
Zearalenone
(ZEA)
is
a
mycotoxin
produced
by
Fusarium
spp.
fungi
and
widely
found
in
moldy
corn,
wheat,
barley,
other
grains.
ZEA
distributed
to
the
whole
body
via
blood
circulation
after
metabolic
transformation
animals.
Through
oxidative
stress,
immunosuppression,
apoptosis,
autophagy,
mitochondrial
dysfunction,
leads
hepatitis,
neurodegenerative
diseases,
cancer,
abortion,
stillbirth
female
animals,
decreased
sperm
motility
male
In
recent
years,
due
influence
of
climate,
storage
facilities,
factors,
problem
pollution
global
food
crops
has
become
particularly
prominent,
resulting
serious
problems
for
animal
husbandry
feed
industries,
threatening
human
health.
Resveratrol
(RSV)
natural
product
with
therapeutic
activities
such
as
anti-inflammatory,
antioxidant,
anticancer
properties.
RSV
can
alleviate
ZEA-induced
toxic
effects
targeting
signaling
pathways
NF-κB,
Nrf2/Keap1,
PI3K/AKT/mTOR
attenuating
damage,
inflammatory
response,
regulating
cellular
autophagy.
Therefore,
this
paper
provides
review
protective
effect
against
toxicity
its
molecular
mechanism,
discusses
safety
potential
clinical
applications
search
detoxification
agents.
Язык: Английский