Emodin Promotes Peripheral Nerve Repair by Modulating Inflammasome Activation Through Autophagy via the EGFR/PI3K/AKT/mTOR Pathway

Phytotherapy Research, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

To investigate the potential of emodin in promoting nerve regeneration following PNI by targeting macrophage polarization, NLRP3 inflammasome activation, autophagy, and EGFR/PI3K/Akt/mTOR pathway. A cohort 78 male Sprague-Dawley rats was used to develop models sciatic damage, with an additional 18 sham surgery group. The were randomly assigned eight groups: Sham, Control, + Emodin (20 mg/kg), (80 MCC950 (10 Rapamycin (2 mg/kg) 3-MA (15 NSC 228155 (5 mg/kg). administered intragastrical daily, while inhibitors or agonist via intraperitoneal injection, as per respective dosages schedules. treatment period included assessments functional recovery, such histological staining, immunofluorescence for cellular markers, TEM ultrastructural changes, SFI western blot analysis autophagy inflammatory proteins. IF images showed that enhanced axonal myelin regeneration. Histological revealed reduced muscular atrophy collagen deposition. decreased pro-inflammatory markers (CD68) increasing M2 (CD206), inhibited inflammasome, IL-1β caspase-1. It activated Schwann cells, increased LC3-II levels. Network pharmacology molecular docking identified EGFR PI3K/AKT/mTOR pathway a key target, inhibiting activation. This study reveals promotes early recovery enhancing outcomes, remyelination, reducing muscle atrophy. boosts inhibits polarization. These effects are closely related EGFR/PI3K/AKT/mTOR

Язык: Английский

---

Dihydromyricetin restores lysosomal function in Schwann cells to alleviate bortezomib-induced peripheral neuropathy via ERK/TFEB signaling

Archives of Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 6, 2025

Язык: Английский

---

A Ginsenoside Composition Ameliorated Aβ and Tau Aggregation via Autophagy Lysosome Pathway

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Май 6, 2025

Язык: Английский

---

Transcription factor EB (TFEB) promotes autophagy in early brain injury after subarachnoid hemorrhage in rats

Neurosurgical Review, Год журнала: 2024, Номер 47(1)

Опубликована: Окт. 8, 2024

Язык: Английский

---