Excellent Foliar Deposition of Cyclodextrin‐Encapsulated Furyl/Thienyl‐Engineered Ingredients: Novel Effective Supramolecular Agrochemicals for Combating Plant Bacterial and Fungal Infections
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(40)
Опубликована: Май 25, 2024
Abstract
Repeated
epidemics
caused
by
bacterial
and
fungal
diseases
pose
a
threat
to
global
crop
yields
food
security,
therefore,
updating
the
structure
of
existing
microbicides
improving
pesticide
bioavailability
are
challenging
tasks,
perhaps
planning
develop
versatile
supramolecular
antimicrobial
materials.
Here,
low‐cost
multifunctional
complex,
named
FT6@
β
‐CD,
is
constructed
host‐guest
encapsulation
thienyl‐engineered
ingredient
(FT6)
into
‐cyclodextrin.
This
integrated
architecture
can
significantly
reduce
bounce
splash
behaviors
droplets,
improve
wetting
performance,
eventually
acquire
excellent
foliar
deposition
targeted
delivery.
Whereafter,
‐CD
inhibit
transcription
type
III
secretion
system
(T3SS)‐associated
genes,
hypersensitive
reaction,
final
pathogenicity
from
destructive
pathogen
Xanthomonas
oryzae
pv.
(
Xoo
).
Importantly,
at
lower
dosage
200
µg
mL
−1
,
presented
in
vivo
control
effects
(protection
48.1%,
curative
50.1%)
against
remarkably
better
than
commercial
bactericidal
formulation
thiodiazole‐copper.
Additionally,
other
antifungal
materials
(FT24/FT25@HP‐
‐CD/
‐CD/Me‐
‐CD)
this
study
effectively
treat
Botryosphaeria
dothidea
Botrytis
cinerea
with
higher
efficiencies
86.8%
90.1%
respectively.
provides
bright
guidance
for
developing
low‐cost,
green,
eco‐friendly
controlling
agricultural
diseases.
Язык: Английский
Extracellular Vesicles and Exosomes in the Control of the Musculoskeletal Health
Current Osteoporosis Reports,
Год журнала:
2024,
Номер
22(2), С. 257 - 265
Опубликована: Март 1, 2024
The
present
review
will
highlight
recent
reports
supporting
the
relevance
of
extracellular
vesicles
to
musculoskeletal
system
in
health
and
disease.
Preserving
is
important
maintain
a
good
quality
life,
bone-muscle
crosstalk
crucial
this
regard.
This
latter
largely
mediated
by
released
different
cell
populations
residing
muscle
bone,
which
deliver
cargoes,
microRNAs,
proteins
being
most
relevant
ones,
target
cells.
Extracellular
could
be
exploited
as
therapeutic
tools,
view
their
resistance
destruction
biological
fluid
possibility
functionalized
according
need.
are
recognized
players
cross-talk.
Additional
studies
however
required
refine
use
biomarkers
early
alterations
system,
potential
tools.
Язык: Английский
Fluazinam Resistance in Colletotrichum gloeosporioides and Its Association with Metabolic Detoxification and Efflux
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Colletotrichum
gloeosporioides
is
a
major
pathogen
causing
anthracnose
of
pepper
(Capsicum
annuum).
In
agricultural
production,
it
typically
managed
using
fungicides
like
fluazinam.
However,
the
frequent
use
raises
concerns
about
potential
development
fungicide
resistance.
This
issue
has
not
been
extensively
documented.
To
address
this,
102
isolates
C.
were
collected
from
in
fields.
The
EC50
values
these
to
fluazinam
exhibited
unimodal
distribution
with
mean
value
0.18
±
0.14
μg/mL,
indicating
absence
naturally
occurring
resistance
sampling
region.
Through
domestication,
35
fluazinam-resistant
mutants
obtained
parental
strain
Cg219.
These
strong
cross-resistance
SYP-14288.
Metabolic
analysis
revealed
that
could
metabolize
into
compounds
lacking
antifungal
activity.
Genetic
showed
genes
related
efflux
and
detoxification
upregulated
varying
degrees
both
fluazinam-treated
strains.
By
comparing
fungal
growth
pathogenicity
between
their
parent,
impaired
overall
fitness.
Therefore,
low
risk
developing
study
provides
critical
data
for
monitoring
emergence
management
strategies
Язык: Английский
Understanding Efflux‐Mediated Multidrug Resistance in Botrytis cinerea for Improved Management of Fungicide Resistance
Microbial Biotechnology,
Год журнала:
2025,
Номер
18(3)
Опубликована: Март 1, 2025
Botrytis
cinerea
is
a
major
fungal
pathogen
infecting
over
1400
plant
species.
It
poses
significant
threat
to
agriculture
due
multiple
fungicide
resistance
and
multidrug
resistance,
involves
fungicides
with
different
modes
of
action.
Multiple
mostly
an
accumulation
point
mutations
in
target
genes
time,
MDR
result
from
efflux
(e-MDR)
metabolism
(m-MDR).
This
review
introduces
the
occurrence
e-MDR
B.
cinerea,
key
mechanisms,
origins
management
strategies
fields.
New
materials
such
as
nanomaterials
become
strategy
overcoming
via
inhibition
ABC
transporter.
A
deeper
understanding
efflux-mediated
will
provide
support
for
efficient
utilization
fungicides.
Язык: Английский
Regulatory role of the transcription factor Bcmr1 in efflux-mediated multidrug resistance in Botrytis cinerea via pre-adaptation to plant secondary metabolites
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 143520 - 143520
Опубликована: Апрель 1, 2025
Язык: Английский
Resistance Risk Assessment of Propiconazole in Rhizoctonia solani and its Synergistic Antifungal Mechanism with Kresoxim-methyl
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 19, 2025
The
resistance
risk
and
mechanisms
of
propiconazole
in
Rhizoctonia
solani
remain
unclear.
In
this
study,
the
sensitivity
159
R.
isolates
to
was
determined,
EC50
value
0.2286
μg/mL.
Nineteen
propiconazole-resistant
mutants
were
obtained
through
fungicide
adaptation,
compound
fitness
indexes
these
lower
than
those
their
parental
isolates.
Cross-resistance
analysis
revealed
that
there
no
cross-resistance
between
other
fungicides,
apart
from
prochloraz.
Although
point
mutations
occurred
RsCYP51
gene
or
its
promoter
regions,
expression
levels
efflux
transporter
genes
increased
substantially
mutants.
Furthermore,
a
1:1
synergistic
combination
kresoxim-methyl
(SCpk(1:1))
could
simultaneously
cause
more
severe
damage
both
cell
membrane
integrity
mitochondrial
function.
Field
trials
demonstrated
SCpk(1:1)
achieved
over
86%
control
efficacy
against
rice
sheath
blight
applied
at
120
g
a.i./ha.
Язык: Английский
Synthetic and Natural Antifungal Substances in Cereal Grain Protection: A Review of Bright and Dark Sides
Molecules,
Год журнала:
2024,
Номер
29(16), С. 3780 - 3780
Опубликована: Авг. 9, 2024
Molds
pose
a
severe
challenge
to
agriculture
because
they
cause
very
large
crop
losses.
For
this
reason,
synthetic
fungicides
have
been
used
for
long
time.
Without
adequate
protection
against
pests
and
various
pathogens,
losses
could
be
as
high
30–40%.
However,
concerns
mainly
about
the
environmental
impact
of
antifungals
human
health
risk
prompted
search
natural
alternatives.
But
do
remedies
only
advantages?
This
article
reviews
current
state
knowledge
on
use
antifungal
substances
in
protect
seeds
phytopathogens.
The
advantages
disadvantages
using
both
cereal
grains
were
discussed,
indicating
specific
examples
mechanisms
action.
possibilities
an
integrated
control
approach,
combining
cultural,
biological,
chemical
methods
are
described,
constituting
holistic
strategy
sustainable
mold
management
grain
industry.
Язык: Английский