Unveiling the mechanism of Latilactobacillus sakei LZ217 cell-free supernatant against Helicobacter pylori through metabolomics and network pharmacology

Food Bioscience, Год журнала: 2025, Номер unknown, С. 105925 - 105925

Опубликована: Янв. 1, 2025

Язык: Английский

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Indole‐3‐Lactic Acid Inhibits Doxorubicin‐Induced Ferroptosis Through Activating Aryl Hydrocarbon Receptor/Nrf2 Signalling Pathway

Journal of Cellular and Molecular Medicine, Год журнала: 2025, Номер 29(2)

Опубликована: Янв. 1, 2025

ABSTRACT The clinical application of doxorubicin (DOX) is limited due to its cardiotoxicity, which primarily attributed interaction with iron in mitochondria, leading lipid peroxidation and myocardial ferroptosis. This study aimed investigate the role gut microbiota‐derived metabolite, indole‐3‐lactic acid (ILA), mitigating DOX‐induced cardiotoxicity (DIC). Cardiac function, pathological changes, ferroptosis were assessed vivo. cardioprotective effects mechanisms ILA explored using multi‐omics approaches, including single‐nucleus RNA sequencing (snRNA‐seq) bulk RNA‐seq, further validated Nrf2 knockout mice. findings revealed that DOX treatment disrupted microbiota, significantly reducing levels tryptophan metabolite ILA. In DIC models, supplementation markedly improved cardiac reduced collagen deposition, mitigated atrophy. snRNA‐seq analyses indicated played a crucial Experimental data demonstrated decreased both mice DOX‐treated H9C2 cells, evidenced by restoration GPX4 SLC7A11 reduction ACSL4. Mechanistically, functions as ligand for aryl hydrocarbon receptor (AhR), upregulation expression. protective against abolished silencing AhR. Moreover, beneficial on eliminated Nrf2‐deficient conclusion, exerts therapeutic inhibiting through activation AhR/Nrf2 signalling pathway. Identifying microbial could offer viable strategies DIC.

Язык: Английский

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Synbiotic combination of Bifidobacterium longum BB536 and lactulose improves the presenteeism of healthy adults associated with aromatic lactic acids - A single-arm, open-label study

Gut Microbes Reports, Год журнала: 2025, Номер 2(1)

Опубликована: Апрель 10, 2025

Язык: Английский

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Untargeted metabolomics reveals biochemical changes in wheat by-products during fermentation

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106158 - 106158

Опубликована: Фев. 1, 2025

Язык: Английский

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Bifidobacterium bifidum 1007478 derived indole-3-lactic acid alleviates NASH via an aromatic hydrocarbon receptor-dependent pathway in zebrafish

Life Sciences, Год журнала: 2025, Номер unknown, С. 123557 - 123557

Опубликована: Март 1, 2025

Язык: Английский

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Synergistic Effect of Formate and Cell-Free Supernatant Fermented by Two Probiotics, Bifidobacterium animalis spp. lactis HN019 and Lacticaseibacillus rhamnosus HN001, against Shigella flexneri Growth

ACS Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Май 15, 2025

The interplay between probiotic metabolites, host health, and inhibition of pathogens has increasingly attracted interest but remains unresolved due to the complex molecular interactions among these factors. We investigated action cell-free supernatants (CFSs) from two bacteria, Bifidobacterium animalis spp. lactis (B. lactis) HN019 Lacticaseibacillus rhamnosus (L. rhamnosus) HN001 their effect against bacterial pathogen Shigella flexneri 2457T (S. flexneri). CFSs B. exhibited a higher antibacterial S. growth than L. HN001, independent carbon source utilized. This correlated with formate within HN019. As expected, antimicrobial effects were stronger free cells for infecting cells. A synergistic additional small organic molecules such as indole-3-lactate was found. Such CFSs, indole-3-lactate, reflected by altered metabolic rates in presence both solution under biofilm-forming conditions. different components acting on gives reasons believe that suitably designed mixtures products small-molecule effectors bear promise successfully combating pathogens.

Язык: Английский

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Buqi-Huoxue-Tongnao decoction drives gut microbiota-derived indole lactic acid to attenuate ischemic stroke via the gut-brain axis

Chinese Medicine, Год журнала: 2024, Номер 19(1)

Опубликована: Сен. 15, 2024

Язык: Английский

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Identification and mechanistic investigation of novel adhesion inhibitory peptides against Helicobacter pylori from corn protein hydrolysates

LWT, Год журнала: 2024, Номер 215, С. 117216 - 117216

Опубликована: Дек. 14, 2024

Язык: Английский

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Lactiplantibacillus plantarum CCFM8610 mitigates oxidative stress-related intestinal aging through its metabolite indole-3-lactic acid

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105822 - 105822

Опубликована: Дек. 1, 2024

Язык: Английский

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